Bradford B. Worrall

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Primary Appointment

Professor, Neurology

Education

  • MD, Emory University

Research Disciplines

Biotechnology

Research Interests

Genetics, inflammation in stroke and other neurological diseases, ethical and methodological issues in genetic research

Research Description


Dr. Worrall’s research approaches genetic issues of cerebrovascular disease from several angles. Currently he is working with the Department of Health Evaluation Sciences on a web-based tool to assess comprehensive family history information in assigning risk and recommending interventions.
In collaboration with the NIH Stroke Branch , Dr. Worrall is looking at genetic polymorphisms of inflammatory mediators in patients with symptomatic carotid atherosclerosis. He works with other members of the stroke group in ongoing clinical trials.

Personal Statement

Dr. Worrall’s research approaches genetic issues of cerebrovascular disease from several angles. Currently he is working with the Department of Health Evaluation Sciences on a web-based tool to assess comprehensive family history information in assigning risk and recommending interventions.
In collaboration with the NIH Stroke Branch , Dr. Worrall is looking at genetic polymorphisms of inflammatory mediators in patients with symptomatic carotid atherosclerosis. He works with other members of the stroke group in ongoing clinical trials.

Selected Publications

2024

Baskin, P. K., Barkhof, F., Burch, R., Callaghan, B. C., Ciccarelli, O., Hedera, P., . . . Merino, J. G. (2024). Open Peer Review Reports: A Pilot Project in Neurology®.. Neurology, 102(9), e209462. doi:10.1212/wnl.0000000000209462

Aldridge, C. M., Braun, R., Lohse, K., de Havenon, A., Cole, J. W., Cramer, S. C., . . . Worrall, B. B. (2024). Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke.. Neurology, 102(3), e208011. doi:10.1212/wnl.0000000000208011

Becerril-Gaitan, A., Ding, D., Ironside, N., Southerland, A. M., Worrall, B. B., Testai, F. D., . . . ERICH investigators. (2024). Association Between Body Mass Index and Functional Outcomes in Patients With Intracerebral Hemorrhage.. Neurology, 102(2), e208014. doi:10.1212/wnl.0000000000208014

2023

Aldridge, C. M., Braun, R., Keene, K. L., Hsu, F. -C., & Worrall, B. B. (2023). Single Nucleotide Polymorphisms Associated With Motor Recovery in Patients With Nondisabling Stroke GWAS Study. NEUROLOGY, 101(21), E2114-E2125. doi:10.1212/WNL.0000000000207716

Characteristics and Clinical Implication of White Matter Lesions in Patients With Adult Moyamoya Disease. (2023). Neurology, 101(9), 416. doi:10.1212/wnl.0000000000207573

de Havenon, A., Bangad, A., Skolarus, L. E., Aldridge, C. M., Braun, R. G., Cole, J. W., . . . Lohse, K. R. (2023). Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data. STROKE, 54(5), E201-E202. doi:10.1161/STROKEAHA.122.042168

Bhole, R., Solenski, N. J., Donahue, J. H., Kellogg, R. T., Roach, N. N., Chapman, S. N., . . . Southerland, A. M. (2023). Best Practice Recommendations for Stroke Vascular Imaging During Iodinated Contrast Shortage. NEUROLOGY-CLINICAL PRACTICE, 13(2). doi:10.1212/CPJ.0000000000200119

Sawyer, R. P., Worrall, B. B., Howard, V. J., Crowe, M. G., Howard, G., & Hyacinth, H. I. (2023). Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment and Dementia. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 12(17). doi:10.1161/JAHA.123.030925

Merino, J. G. R., Ciccarelli, O. O., Worrall, B., Aamodt, W. W., Amato, A., Burch, R. A., . . . Strowd, R. (2023). Message From the Editors to Our Reviewers. NEUROLOGY, 100(1), 1-8. doi:10.1212/WNL.0000000000201681

2022

Bretzner, M., Bonkhoff, A. K., Schirmer, M. D., Hong, S., Dalca, A., Donahue, K., . . . Rost, N. S. (2023). Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke. NEUROLOGY, 100(8), E822-E833. doi:10.1212/WNL.0000000000201596

Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., . . . Debette, S. (2022). Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.. Nature, 612(7938), E7. doi:10.1038/s41586-022-05492-5

Mishra, A., Malik, R., Hachiya, T., Jurgenson, T., Namba, S., Posner, D. C., . . . Debette, S. (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. NATURE, 611(7934), 115-+. doi:10.1038/s41586-022-05165-3

Narrett, J. A., Aldridge, C. M., Garrett, J., Abdalla, B., Donahue, J., Worrall, B. B., & Southerland, A. M. (2022). Vertebral Artery Tortuosity and Morphometric Characteristics of Patients with Recurrent Cervical Artery Dissection. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(5). doi:10.1016/j.jstrokecerebrovasdis.2022.106346

Mishra, N. K., Engel, J., Liebeskind, D. S., Sharma, V. K., Hirsch, L. J., Kasner, S. E., . . . for International Post Stroke Epilepsy Research Consortium (IPSERC). (2022). International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke.. Epilepsy & behavior : E&B, 127, 108502. doi:10.1016/j.yebeh.2021.108502

Jaworek, T., Xu, H., Gaynor, B. J., Cole, J. W., Rannikmae, K., Stanne, T. M., . . . Kittner, S. J. (2022). Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke. NEUROLOGY, 99(16), E1738-E1754. doi:10.1212/WNL.0000000000201006

Aldridge, C. M., McDonald, M. M., Wruble, M., Zhuang, Y., Uribe, O., McMurry, T. L., . . . Southerland, A. M. (2022). Human vs. Machine Learning Based Detection of Facial Weakness Using Video Analysis. FRONTIERS IN NEUROLOGY, 13. doi:10.3389/fneur.2022.878282

Ironside, N., Patrie, J., Ng, S., Ding, D., Rizvi, T., Kumar, J. S., . . . Chen, C. -J. (2022). Quantification of hematoma and perihematomal edema volumes in intracerebral hemorrhage study: Design considerations in an artificial intelligence validation (QUANTUM) study. CLINICAL TRIALS, 19(5), 534-544. doi:10.1177/17407745221105886

Bonkhoff, A. K., Hong, S., Bretzner, M., Schirmer, M. D., Regenhardt, R. W., Arsava, E. M., . . . Rost, N. S. (2022). Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome. NEUROLOGY, 99(13), E1364-E1379. doi:10.1212/WNL.0000000000200926

James, M. L., Troy, J., Nowacki, N., Komisarow, J., Swisher, C. B., Tucker, K., . . . Laskowitz, D. T. (2022). CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial (vol 36, pg 216, 2022). NEUROCRITICAL CARE, 37(2), 610. doi:10.1007/s12028-022-01553-9

Frid, P., Xu, H., Mitchell, B. D., Drake, M., Wasselius, J., Gaynor, B., . . . Lindgren, A. (2022). Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(8). doi:10.1016/j.jstrokecerebrovasdis.2022.106546

Woo, D., Comeau, M. E., Venema, S. U., Anderson, C. D., Flaherty, M., Testai, F., . . . Langefeld, C. D. (2022). Risk Factors Associated With Mortality and Neurologic Disability After Intracerebral Hemorrhage in a Racially and Ethnically Diverse Cohort. JAMA NETWORK OPEN, 5(3). doi:10.1001/jamanetworkopen.2022.1103

Bonkhoff, A. K., Bretzner, M., Hong, S., Schirmer, M. D., Cohen, A., Regenhardt, R. W., . . . Rost, N. S. (2022). Sex-specific lesion pattern of functional outcomes after stroke. BRAIN COMMUNICATIONS, 4(2). doi:10.1093/braincomms/fcac020

de Havenon, A., Heitsch, L., Sunmonu, A., Braun, R., Lohse, K. R., Cole, J. W., . . . Cramer, S. C. (2022). Accurate Prediction of Persistent Upper Extremity Impairment in Patients With Ischemic Stroke. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 103(5), 964-969. doi:10.1016/j.apmr.2021.10.023

James, M. L., Troy, J., Nowacki, N., Komisarow, J., Swisher, C. B., Tucker, K., . . . Laskowitz, D. T. (2022). CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial. NEUROCRITICAL CARE, 36(1), 216-225. doi:10.1007/s12028-021-01287-0

Lindgren, A. G., Braun, R. G., Juhl Majersik, J., Clatworthy, P., Mainali, S., Derdeyn, C. P., . . . Fernandez-Cadenas, I. (2022). International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery. INTERNATIONAL JOURNAL OF STROKE, 17(3), 260-268. doi:10.1177/17474930211007288

Chen, C. -J., Chalhoub, R., Ding, D., Kumar, J. S., Ironside, N., Kellogg, R. T., . . . Park, M. S. (2022). Is a picture-perfect thrombectomy necessary in acute ischemic stroke?. JOURNAL OF NEUROINTERVENTIONAL SURGERY, 14(2), 111-+. doi:10.1136/neurintsurg-2020-017193

2021

Ken-Dror, G., Cotlarciuc, I., Martinelli, I., Grandone, E., Hiltunen, S., Lindgren, E., . . . Sharma, P. (2021). Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis. ANNALS OF NEUROLOGY, 90(5), 777-788. doi:10.1002/ana.26205

Chung, J., Hamilton, G., Kim, M., Marini, S., Montgomery, B., Henry, J., . . . Anderson, C. D. (2021). Rare Missense Functional Variants at COL4A1 and COL4A2 in Sporadic Intracerebral Hemorrhage. NEUROLOGY, 97(3), E236-E247. doi:10.1212/WNL.0000000000012227

Braun, R. G., Heitsch, L., Cole, J. W., Lindgren, A. G., de Havenon, A., Dude, J. A., . . . Worrall, B. B. (2021). Domain-Specific Outcomes for Stroke Clinical Trials What the Modified Rankin Isn't Ranking. NEUROLOGY, 97(8), 367-377. doi:10.1212/WNL.0000000000012231

Bonkhoff, A. K., Schirmer, M. D., Bretzner, M., Hong, S., Regenhardt, R. W., Brudfors, M., . . . Rost, N. S. (2021). Outcome after acute ischemic stroke is linked to sex-specific lesion patterns. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23492-3

de Havenon, A., Tirschwell, D. L., Heitsch, L., Cramer, S. C., Braun, R., Cole, J., . . . Worrall, B. B. (2021). Variability of the Modified Rankin Scale Score Between Day 90 and 1 Year After Ischemic Stroke. NEUROLOGY-CLINICAL PRACTICE, 11(3), E239-E244. doi:10.1212/CPJ.0000000000000954

Bakker, M. K., van der Spek, R. A. A., van Rheenen, W., Morel, S., Bourcier, R., Hostettler, I. C., . . . Ruigrok, Y. M. (2021). Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.. Nature genetics, 53(2), 254. doi:10.1038/s41588-020-00760-4

Johansson, M., Pedersen, A., Cole, J. W., Lagging, C., Lindgren, A., Maguire, J. M., . . . Jern, C. (2021). Genetic Predisposition to Mosaic Chromosomal Loss Is Associated With Functional Outcome After Ischemic Stroke. NEUROLOGY-GENETICS, 7(6). doi:10.1212/NXG.0000000000000634

Sunmonu, N. A., Ambati, N. K., Thomas, M. J., Ulep, R. D., & Worrall, B. (2021). First report: Rare RNF213 variant associated with familial moyamoya disease in an African American family. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 30(12). doi:10.1016/j.jstrokecerebrovasdis.2021.106123

Hong, S., Giese, A. -K., Schirmer, M. D., Bonkhoff, A. K., Bretzner, M., Rist, P., . . . Rost, N. S. (2021). Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke. FRONTIERS IN NEUROLOGY, 12. doi:10.3389/fneur.2021.700616

Kittner, S. J., Sekar, P., Comeau, M. E., Anderson, C. D., Parikh, G. Y., Tavarez, T., . . . Woo, D. (2021). Ethnic and Racial Variation in Intracerebral Hemorrhage Risk Factors and Risk Factor Burden. JAMA NETWORK OPEN, 4(8). doi:10.1001/jamanetworkopen.2021.21921

Bretzner, M., Bonkhoff, A. K., Schirmer, M. D., Hong, S., Dalca, A. V., Donahue, K. L., . . . Rost, N. S. (2021). MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes. FRONTIERS IN NEUROSCIENCE, 15. doi:10.3389/fnins.2021.691244

Kearns, K. N., Ironside, N., Park, M. S., Worrall, B. B., Southerland, A. M., Chen, C. -J., & Ding, D. (2021). Neuroprotective Therapies for Spontaneous Intracerebral Hemorrhage. NEUROCRITICAL CARE, 35(3), 862-886. doi:10.1007/s12028-021-01311-3

Armstrong, N. M. D., Chen, W. -M., Hsu, F. -C., Brewer, M. S., Cullell, N., Fernandez-Cadenas, I., . . . Keene, K. L. (2021). DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial. PLOS ONE, 16(7). doi:10.1371/journal.pone.0254562

Engelter, S. T., Traenka, C., Grond-Ginsbach, C., Brandt, T., Hakimi, M., Worrall, B. B., . . . Lyrer, P. (2021). Cervical Artery Dissection and Sports. FRONTIERS IN NEUROLOGY, 12. doi:10.3389/fneur.2021.663830

Armstrong, N. M. D., Spragley, K. J., Chen, W. -M., Hsu, F. -C., Brewer, M. S., Horn, P. J., . . . Keene, K. L. (2021). Multi-omic analysis of stroke recurrence in African Americans from the Vitamin Intervention for Stroke Prevention (VISP) clinical trial. PLOS ONE, 16(3). doi:10.1371/journal.pone.0247257

Southerland, A. M., Green, I. E., & Worrall, B. B. (2021). Cerebral aneurysms and cervical artery dissection: Neurological complications and genetic associations.. Handbook of clinical neurology, 177, 241-251. doi:10.1016/b978-0-12-819814-8.00033-0

McCabe, J. J., O'Reilly, E., Coveney, S., Collins, R., Healy, L., McManus, J., . . . Kelly, P. J. (2021). Interleukin-6, C-reactive protein, fibrinogen, and risk of recurrence after ischaemic stroke: Systematic review and meta-analysis. EUROPEAN STROKE JOURNAL, 6(1), 62-71. doi:10.1177/2396987320984003

Cole, D. F. J., Wiggins, R., Carrera, J., & Worrall, B. (2021). Teaching Video NeuroImages: From 9 to 8-and-a-Half Syndrome After tPA The Rebirth of Fellini. NEUROLOGY, 96(12), E1699-E1700. doi:10.1212/WNL.0000000000011160

2020

Bakker, M. K., van der Spek, R. A. A., van Rheenen, W., Morel, S., Bourcier, R., Hostettler, I. C., . . . Ruigrok, Y. M. (2020). Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. NATURE GENETICS, 52(12), 1303-1313. doi:10.1038/s41588-020-00725-7

Keene, K. L., Hyacinth, H. I., Bis, J. C., Kittner, S. J., Mitchell, B. D., Cheng, Y. -C., . . . Fornage, M. (2020). Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. STROKE, 51(8), 2454-2463. doi:10.1161/STROKEAHA.120.029123

Kwon, Y., McHugh, S., Ghoreshi, K., Lyons, G. R., Cho, Y., Bilchick, K. C., . . . Soliman, E. Z. (2020). Electrocardiographic left atrial abnormality in patients presenting with ischemic stroke. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 29(9). doi:10.1016/j.jstrokecerebrovasdis.2020.105086

Schirmer, M. D., Donahue, K. L., Nardin, M. J., Dalca, A. V., Giese, A. -K., Etherton, M. R., . . . Rost, N. S. (2020). Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke. MAYO CLINIC PROCEEDINGS, 95(5), 955-965. doi:10.1016/j.mayocp.2020.01.027

Lillicrap, T., Keragala, C. B., Draxler, D. F., Chan, J., Ho, H., Harman, S., . . . Medcalf, R. L. (2020). Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples. FRONTIERS IN NEUROLOGY, 11. doi:10.3389/fneur.2020.589628

Merino, J. G., Worrall, B. B., Baskin, P. K., & Ciccarelli, O. (2020). Neurology®'s commitment to address gender bias in neurology journals. NEUROLOGY, 95(11), 465-466. doi:10.1212/WNL.0000000000010539

Drake, M., Frid, P., Hansen, B. M., Wu, O., Giese, A. -K., Schirmer, M. D., . . . Wasselius, J. (2020). Diffusion-Weighted Imaging, MR Angiography, and Baseline Data in a Systematic Multicenter Analysis of 3,301 MRI Scans of Ischemic Stroke Patients-Neuroradiological Review Within the MRI-GENIE Study. FRONTIERS IN NEUROLOGY, 11. doi:10.3389/fneur.2020.00577

Biffi, A., Urday, S., Kubiszewski, P., Gilkerson, L., Sekar, P., Rodriguez-Torres, A., . . . Rosand, J. (2020). Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. STROKE, 51(7), 2153-2160. doi:10.1161/STROKEAHA.120.028310

Giese, A. -K., Schirmer, M. D., Dalca, A. V., Sridharan, R., Donahue, K. L., Nardin, M., . . . Rost, N. S. (2020). White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype. NEUROLOGY, 95(1), E79-E88. doi:10.1212/WNL.0000000000009728

Leira, E. C., Russman, A. N., Biller, J., Brown, D. L., Bushnell, C. D., Caso, V., . . . Worrall, B. B. (2020). Preserving stroke care during the COVID-19 pandemic Potential issues and solutions. NEUROLOGY, 95(3), 124-133. doi:10.1212/WNL.0000000000009713

Falcone, G. J., Kirsch, E., Acosta, J. N., Noche, R. B., Leasure, A., Marini, S., . . . Anderson, C. D. (2020). Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage. ANNALS OF NEUROLOGY, 88(1), 56-66. doi:10.1002/ana.25740

Holliday, E., Lillicrap, T., Kleinig, T., Choi, P. M. C., Maguire, J., Bivard, A., . . . Levi, C. (2020). Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study. BMJ OPEN, 10(4). doi:10.1136/bmjopen-2020-038180

von Berg, J., van der Laan, S. W., McArdle, P. F., Malik, R., Kittner, S. J., Mitchell, B. D., . . . Pulit, S. L. (2020). Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke. EUROPEAN JOURNAL OF HUMAN GENETICS, 28(7), 963-972. doi:10.1038/s41431-020-0580-5

Chen, C. -J., Green, I. E., Worrall, B. B., & Southerland, A. M. (2020). Cerebral collaterals and stroke in patients with isolated carotid artery dissections. JOURNAL OF CLINICAL NEUROSCIENCE, 72, 158-162. doi:10.1016/j.jocn.2019.12.038

Carrera, J. F., Sorace, B. J., Worrall, B. B., Southerland, A. M., & Chiota-McCollum, N. A. (2020). Delay to Tissue Plasminogen Activator in Hypertensive Stroke Patients: An Analysis of Delay Duration Across Agents. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 29(2). doi:10.1016/j.jstrokecerebrovasdis.2019.104525

Green, I. E., Williams, S. R., Sale, M. M., Keene, K. L., Worrall, B. B., & Southerland, A. M. (2020). Differential expression of PHACTR1 in atheromatous versus normal carotid artery tissue. JOURNAL OF CLINICAL NEUROSCIENCE, 74, 265-267. doi:10.1016/j.jocn.2020.01.018

Chen, C. -J., Ding, D., Ironside, N., Buell, T. J., Southerland, A. M., Testai, F. D., . . . Worrall, B. B. (2020). Intracranial pressure monitoring in patients with spontaneous intracerebral hemorrhage. JOURNAL OF NEUROSURGERY, 132(6), 1854-1864. doi:10.3171/2019.3.JNS19545

2019

Traenka, C., Grond-Ginsbach, C., Simonetti, B. G., Metso, T. M., Debette, S., Pezzini, A., . . . Lyrer, P. (2020). Artery occlusion independently predicts unfavorable outcome in cervical artery dissection. NEUROLOGY, 94(2), E170-E180. doi:10.1212/WNL.0000000000008654

Frid, P., Drake, M., Giese, A. K., Wasselius, J., Schirmer, M. D., Donahue, K. L., . . . Lindgren, A. (2020). Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study. JOURNAL OF NEUROLOGY, 267(3), 649-658. doi:10.1007/s00415-019-09613-5

Chung, J., Marini, S., Pera, J., Norrving, B., Jimenez-Conde, J., Roquer, J., . . . Anderson, C. D. (2019). Genome-wide association study of cerebral small vessel disease reveals established and novel loci. BRAIN, 142, 3176-3189. doi:10.1093/brain/awz233

Leasure, A. C., Sheth, K. N., Comeau, M., Aldridge, C., Worrall, B. B., Vashkevich, A., . . . Falcone, G. J. (2019). Identification and Validation of Hematoma Volume Cutoffs in Spontaneous, Supratentorial Deep Intracerebral Hemorrhage. STROKE, 50(8), 2044-2049. doi:10.1161/STROKEAHA.118.023851

Soderholm, M., Pedersen, A., Lorentzen, E., Stanne, T. M., Bevan, S., Olsson, M., . . . Jern, C. (2019). Genome-wide association meta-analysis of functional outcome after ischemic stroke. NEUROLOGY, 92(12), E1271-E1283. doi:10.1212/WNL.0000000000007138

Valdes-Marquez, E., Parish, S., Clarke, R., Stari, T., Worrall, B. B., Hopewell, J. C., . . . Cheng, Y. -C. (2019). Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study. NEUROLOGY, 92(11), E1176-E1187. doi:10.1212/WNL.0000000000007091

Chen, C. -J., Ding, D., Lronside, N., Buell, T. J., Southerland, A. M., Woo, D., & Worrall, B. B. (2019). Predictors of Surgical Intervention in Patients with Spontaneous Intracerebral Hemorrhage. WORLD NEUROSURGERY, 123, E700-E708. doi:10.1016/j.wneu.2018.11.260

Georgakis, M. K., Gill, D., Rannikmaee, K., Traylor, M., Anderson, C. D., Lee, J. -M., . . . Dichgans, M. (2019). Genetically Determined Levels of Circulating Cytokines and Risk of Stroke: Role of Monocyte Chemoattractant Protein-1. CIRCULATION, 139(2), 256-268. doi:10.1161/CIRCULATIONAHA.118.035905

Chen, C. -J., Ding, D., Ironside, N., Buell, T. J., Elder, L. J., Warren, A., . . . Southerland, A. M. (2019). Statins for neuroprotection in spontaneous intracerebral hemorrhage. NEUROLOGY, 93(24), 1056-1066. doi:10.1212/WNL.0000000000008627

Schirmer, M. D., Dalca, A. V., Sridharan, R., Giese, A. -K., Donahue, K. L., Nardin, M. J., . . . Rost, N. S. (2019). White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts - The MRI-GENIE study. NEUROIMAGE-CLINICAL, 23. doi:10.1016/j.nicl.2019.101884

Wu, O., Winzeck, S., Giese, A. -K., Hancock, B. L., Etherton, M. R., Bouts, M. J. R. J., . . . Rost, N. S. (2019). Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data. STROKE, 50(7), 1734-1741. doi:10.1161/STROKEAHA.119.025373

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Dichgans, M. (2019). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (vol 50, pg 524, 2018). NATURE GENETICS, 51(7), 1192-1193. doi:10.1038/s41588-019-0449-0

Chauhan, G., Adams, H. H. H., Satizabal, C. L., Bis, J. C., Teumer, A., Sargurupremraj, M., . . . Debette, S. (2019). Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. NEUROLOGY, 92(5), E486-E503. doi:10.1212/WNL.0000000000006851

Chen, C. -J., Ding, D., Ironside, N., Buell, T. J., Southerland, A. M., Koch, S., . . . Worrall, B. B. (2019). Cigarette Smoking History and Functional Outcomes After Spontaneous Intracerebral Hemorrhage. STROKE, 50(3), 588-594. doi:10.1161/STROKEAHA.118.023580

Marini, S., Crawford, K., Morotti, A., Lee, M. J., Pezzini, A., Moomaw, C. J., . . . Sheth, K. (2019). Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity A Meta-analysis. JAMA NEUROLOGY, 76(4), 480-491. doi:10.1001/jamaneurol.2018.4519

Lyden, P., Pryor, K. E., Coffey, C. S., Cudkowicz, M., Conwit, R., Jadhav, A., . . . Andersen, M. (2019). Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. ANNALS OF NEUROLOGY, 85(1), 125-136. doi:10.1002/ana.25383

Mola-Caminal, M., Carrera, C., Soriano-Tarraga, C., Giralt-Steinhauer, E., Diaz-Navarro, R. M., Tur, S., . . . Jimenez-Conde, J. (2019). PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome A Genome-Wide Meta-Analysis. CIRCULATION RESEARCH, 124(1), 114-120. doi:10.1161/CIRCRESAHA.118.313533

Touze, E., Southerland, A. M., Boulanger, M., Labeyrie, P. -E., Azizi, M., Bouatia-Naji, N., . . . Plouin, P. -F. (2019). Fibromuscular Dysplasia and Its Neurologic Manifestations A Systematic Review. JAMA NEUROLOGY, 76(2), 217-226. doi:10.1001/jamaneurol.2018.2848

Ding, D., Sekar, P., Moomaw, C. J., Comeau, M. E., James, M. L., Testai, F., . . . Osborne, J. (2019). Venous Thromboembolism in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter Study. NEUROSURGERY, 84(6), E304-E310. doi:10.1093/neuros/nyy333

2018

Pulit, S. L., Weng, L. -C., McArdle, P. F., Trinquart, L., Choi, S. H., Mitchell, B. D., . . . Sheth, K. (2018). Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. NEUROLOGY-GENETICS, 4(6). doi:10.1212/NXG.0000000000000293

Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., . . . Alizadeh, B. Z. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. AMERICAN JOURNAL OF HUMAN GENETICS, 103(5), 691-706. doi:10.1016/j.ajhg.2018.09.009

Tylee, D. S., Sun, J., Hess, J. L., Tahir, M. A., Sharma, E., Malik, R., . . . Glatt, S. J. (2018). Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 177(7), 641-657. doi:10.1002/ajmg.b.32652

Roselli, C., Chaffin, M. D., Weng, L. -C., Aeschbacher, S., Ahlberg, G., Albert, C. M., . . . Ellinor, P. T. (2018). Multi-ethnic genome-wide association study for atrial fibrillation. NATURE GENETICS, 50(9), 1225-+. doi:10.1038/s41588-018-0133-9

Chen, C. -J., Ding, D., Buell, T. J., Testai, F. D., Koch, S., Woo, D., & Worrall, B. B. (2018). Restarting antiplatelet therapy after spontaneous intracerebral hemorrhage Functional outcomes. NEUROLOGY, 91(1), E26-E36. doi:10.1212/WNL.0000000000005742

Chen, C. -J., Sorace, B. J., Shakeri, A., Park, M. S., Southerland, A. M., Worrall, B. B., & Kalani, M. Y. S. (2018). Tyrosine kinase inhibitor induced rapidly progressive vasculopathy after intracranial stent placement.. BMJ case reports, 2018, bcr-2018-013777. doi:10.1136/bcr-2018-013777

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Dichgans, M. (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. NATURE GENETICS, 50(4), 524-+. doi:10.1038/s41588-018-0058-3

Green, I. E., Rahman, S. A., Owens, D. L., Sale, M. M., Currie, L. J., Keene, K. L., . . . Southerland, A. M. (2018). Cervical Artery Dissection in Patients of African Ancestry. CEREBROVASCULAR DISEASES, 46(5-6), 218-222. doi:10.1159/000494704

Cole, J. W., Xu, H., Ryan, K., Jaworek, T., Dueker, N., McArdle, P., . . . Mitchell, B. D. (2018). Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke. PLOS ONE, 13(11). doi:10.1371/journal.pone.0206554

van der Laan, S. W., Siemelink, M. A., Haitjema, S., Asl, H. F., Perisic, L., Mokry, M., . . . Pasterkamp, G. (2018). Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 11(9). doi:10.1161/CIRCGEN.118.002115

Armstrong, N. M. D., Chen, W. -M., Brewer, M. S., Williams, S. R., Sale, M. M., Worrall, B. B., & Keene, K. L. (2018). Epigenome-Wide Analyses Identify Two Novel Associations With Recurrent Stroke in the Vitamin Intervention for Stroke Prevention Clinical Trial. FRONTIERS IN GENETICS, 9. doi:10.3389/fgene.2018.00358

Chen, C. -J., Chuang, T. -Y., Hansen, L., Dutta, S., Ding, D., Buell, T. J., . . . Kalani, M. Y. S. (2018). Predictors of 30-day mortality after endovascular mechanical thrombectomy for acute ischemic stroke. JOURNAL OF CLINICAL NEUROSCIENCE, 57, 38-42. doi:10.1016/j.jocn.2018.08.044

Compter, A., Schilling, S., Vaineau, C. J., Goeggel-Simonetti, B., Metso, T. M., Southerland, A., . . . Debette, S. (2018). Determinants and outcome of multiple and early recurrent cervical artery dissections. NEUROLOGY, 91(8), E769-E780. doi:10.1212/WNL.0000000000006037

Ilyas, A., Chen, C. -J., Ding, D., Foreman, P. M., Buell, T. J., Ironside, N., . . . Worrall, B. B. (2018). Letter to the Editor Regarding "Endovascular Mechanical Thrombectomy for Acute Ischemic Stroke Under General Anesthesia Versus Conscious Sedation: A Systematic Review and Meta-Analysis" Reply. WORLD NEUROSURGERY, 115, 489. doi:10.1016/j.wneu.2018.04.111

Marini, S., Devan, W. J., Radmanesh, F., Miyares, L., Poterba, T., Hansen, B. M., . . . Falcone, G. J. (2018). 17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage. STROKE, 49(7), 1618-1625. doi:10.1161/STROKEAHA.117.020091

Chen, C. -J., Sorace, B. J., Shakeri, A., Park, M. S., Southerland, A. M., Worrall, B. B., & Kalani, M. Y. S. (2018). Tyrosine kinase inhibitor induced rapidly progressive vasculopathy after intracranial stent placement. JOURNAL OF NEUROINTERVENTIONAL SURGERY, 10(11). doi:10.1136/neurintsurg-2018-013777.rep

Ilyas, A., Chen, C. -J., Ding, D., Foreman, P. M., Buell, T. J., Ironside, N., . . . Worrall, B. B. (2018). Endovascular Mechanical Thrombectomy for Acute Ischemic Stroke Under General Anesthesia Versus Conscious Sedation: A Systematic Review and Meta-Analysis. WORLD NEUROSURGERY, 112, E355-E367. doi:10.1016/j.wneu.2018.01.049

Hopewell, J. C., Malik, R., Valdes-Marquez, E., Worrall, B. B., & Collins, R. (2018). Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke. EUROPEAN HEART JOURNAL, 39(5), 354-+. doi:10.1093/eurheartj/ehx373

2017

Lapides, D. A., Abusamaan, M. S., Davick, J. J., Sharma, A. M., Mandell, J. W., Lopes, M. B. S., . . . Southerland, A. M. (2017). Segmental arterial mediolysis A rare cause of rapidly progressive arterial dissections. NEUROLOGY-CLINICAL PRACTICE, 7(6), E43-E46. doi:10.1212/CPJ.0000000000000403

Phuah, C. -L., Dave, T., Malik, R., Raffeld, M. R., Ayres, A. M., Goldstein, J. N., . . . International Stroke Genetics Consortium. (2017). Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke.. Brain : a journal of neurology, 140(10), 2663-2672. doi:10.1093/brain/awx220

Rannikme, K., Sivakumaran, V., Millar, H., Malik, R., Anderson, C. D., Chong, M., . . . Sudlow, C. L. M. (2017). COL4A2 is associated with lacunar ischemic stroke and deep ICH Meta-analyses among 21,500 cases and 40,600 controls. NEUROLOGY, 89(17), 1829-1839. doi:10.1212/WNL.0000000000004560

Chen, D. T., & Worrall, B. B. (2017). Comment: Capacity, consent, and country in acute stroke research. NEUROLOGY, 89(13), 1406. doi:10.1212/WNL.0000000000004429

James, M. L., Langefeld, C. D., Sekar, P., Moomaw, C. J., Elkind, M. S. V., Worrall, B. B., . . . Woo, D. (2017). Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage. NEUROLOGY, 89(10), 1011-1019. doi:10.1212/WNL.0000000000004255

Guha, R., Boehme, A., Demel, S. L., Li, J. J., Cai, X., James, M. L., . . . Chaturvedi, S. (2017). Aggressiveness of care following intracerebral hemorrhage in women and men. NEUROLOGY, 89(4), 349-354. doi:10.1212/WNL.0000000000004143

Dale, C. E., Fatemifar, G., Palmer, T. M., White, J., Prieto-Merino, D., Zabaneh, D., . . . Casas, J. P. (2017). Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus A Mendelian Randomization Analysis. CIRCULATION, 135(24), 2373-+. doi:10.1161/CIRCULATIONAHA.116.026560

Haycock, P. C., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., . . . Smith, G. D. (2017). Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study. JAMA ONCOLOGY, 3(5), 636-651. doi:10.1001/jamaoncol.2016.5945

Worrall, B. B. (2017). Nothing like a spirited debate!. NEUROLOGY, 88(21), 1986-1987. doi:10.1212/WNL.0000000000003970

Chen, C. -J., Brown, W. M., Moomaw, C. J., Langefeld, C. D., Osborne, J., Worrall, B. B., . . . Koch, S. (2017). Alcohol use and risk of intracerebral hemorrhage. NEUROLOGY, 88(21), 2043-2051. doi:10.1212/WNL.0000000000003952

Maguire, J. M., Bevan, S., Stanne, T. M., Lorenzen, E., Fernandez-Cadenas, I., Hankey, G. J., . . . Lindgren, A. (2017). GISCOME - Genetics of Ischaemic Stroke Functional Outcome network: A protocol for an international multicentre genetic association study. EUROPEAN STROKE JOURNAL, 2(3), 229-237. doi:10.1177/2396987317704547

Christophersen, I. E., Rienstra, M., Roselli, C., Yin, X., Geelhoed, B., Barnard, J., . . . Ellinor, P. T. (2017). Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. NATURE GENETICS, 49(6), 946-+. doi:10.1038/ng.3843

Traenka, C., Dougoud, D., Simonetti, B. G., Metso, T. M., Debette, S., Pezzini, A., . . . Engelter, S. T. (2017). Cervical artery dissection in patients â¥60 years Often painless, few mechanical triggers. NEUROLOGY, 88(14), 1313-1320. doi:10.1212/WNL.0000000000003788

Kidwell, C. S., Rosand, J., Norato, G., Dixon, S., Worrall, B. B., James, M. L., . . . Woo, D. (2017). Ischemic lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage. NEUROLOGY, 88(8), 782-788. doi:10.1212/WNL.0000000000003630

Giese, A. -K., Schirmer, M. D., Donahue, K. L., Cloonan, L., Irie, R., Winzeck, S., . . . Rost, N. S. (2017). Design and rationale for examining neuroimaging genetics in ischemic stroke The MRI-GENIE study. NEUROLOGY-GENETICS, 3(5). doi:10.1212/NXG.0000000000000180

Chen, C. -J., Wang, C., Buell, T. J., Ding, D., Raper, D. M., Ironside, N., . . . Worrall, B. B. (2017). Endovascular Mechanical Thrombectomy for Acute Middle Cerebral Artery M2 Segment Occlusion: A Systematic Review. WORLD NEUROSURGERY, 107, 684-691. doi:10.1016/j.wneu.2017.08.108

Guerrero, W. R., Gonzales, N. R., Sekar, P., Kawano-Castillo, J., Moomaw, C. J., Worrall, B. B., . . . Woo, D. (2017). Variability in the Use of Platelet Transfusion in Patients with Intracerebral Hemorrhage: Observations from the Ethnic/Racial Variations of Intracerebral Hemorrhage Study. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 26(9), 1974-1980. doi:10.1016/j.jstrokecerebrovasdis.2017.06.014

Berthaud, J. V., & Worrall, B. B. (2017). Can the Spot Sign Identify Who Benefits From Aggressive Blood Pressure Reduction in Intracerebral Hemorrhage?. JAMA NEUROLOGY, 74(8), 905-907. doi:10.1001/jamaneurol.2017.1022

Williams, S. R., Hsu, F. -C., Keene, K. L., Chen, W. -M., Dzhivhuho, G., Rowles, J. L. I. I. I., . . . Sale, M. M. (2017). Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke. STROKE, 48(6), 1444-+. doi:10.1161/STROKEAHA.116.015677

Fernandez-Cadenas, I., Mendioroz, M., Giralt, D., Nafria, C., Garcia, E., Carrera, C., . . . Montaner, J. (2017). GRECOS Project (Genotyping Recurrence Risk of Stroke) The Use of Genetics to Predict the Vascular Recurrence After Stroke. STROKE, 48(5), 1147-+. doi:10.1161/STROKEAHA.116.014322

Traylor, M., Malik, R., Nalls, M. A., Cotlarciuc, I., Radmanesh, F., Thorleifsson, G., . . . Markus, H. S. (2017). Genetic Variation at 16q24.2 Is Associated With Small Vessel Stroke. ANNALS OF NEUROLOGY, 81(3), 383-394. doi:10.1002/ana.24840

2016

Hughes, T. M., & Worrall, B. B. (2016). Acute interatrial block is a distinct risk factor for ischemic stroke. NEUROLOGY, 87(4), 344-345. doi:10.1212/WNL.0000000000002905

Smith, S. N. C., Govindarajan, P., Padrick, M. M., Lippman, J. M., McMurry, T. L., Resler, B. L., . . . Southerland, A. M. (2016). A low-cost, tablet-based option for prehospital neurologic assessment: The iTREAT Study. NEUROLOGY, 87(1), 19-26. doi:10.1212/WNL.0000000000002799

Woo, D., Kruger, A. J., Sekar, P., Haverbusch, M., Osborne, J., Moomaw, C. J., . . . Flaherty, M. L. (2016). Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage. NEUROLOGY, 86(10), 905-911. doi:10.1212/WNL.0000000000002449

Chen, C. -J., Ding, D., Starke, R. M., Liu, K. C., Southerland, A. M., & Worrall, B. B. (2016). ENDOVASCULAR VS MEDICAL MANAGEMENT OF ACUTE ISCHEMIC STROKE Response. NEUROLOGY, 86(24), 2316.

Carrera, C., Jimenez-Conde, J., Derdak, S., Rabionet, K., Vives-Bauza, C., Soriano-Tarrega, C., . . . Fernandez-Cadenas, I. (2016). Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke. THROMBOSIS AND HAEMOSTASIS, 116(6), 1165-1171. doi:10.1160/TH16-02-0113

Anderson, C. D., Falcone, G. J., Phuah, C. -L., Radmanesh, F., Brouwers, H. B., Battey, T. W. K., . . . Rosand, J. (2016). Genetic variants in CETP increase risk of intracerebral hemorrhage. ANNALS OF NEUROLOGY, 80(5), 730-740. doi:10.1002/ana.24780

Ehrlich, M. E., Worrall, B. B., & Southerland, A. M. (2016). Response by Ehrlich et al to Letter Regarding Article, "Safety of Computed Tomographic Angiography in the Evaluation of Patients With Acute Stroke: A Single-Center Experience". STROKE, 47(11), E258. doi:10.1161/STROKEAHA.116.015205

van der Laan, S. W., Fall, T., Soumare, A., Teumer, A., Sedaghat, S., Baumert, J., . . . Asselbergs, F. W. (2016). Cystatin C and Cardiovascular Disease A Mendelian Randomization Study. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(9), 934-945. doi:10.1016/j.jacc.2016.05.092

Ball, B. Z., Jiang, B., Mehndiratta, P., Stukenborg, G. J., Upchurch, G. R. J., Meschia, J. F., . . . Southerland, A. M. (2016). Screening individuals with intracranial aneurysms for abdominal aortic aneurysms is cost-effective based on estimated coprevalence. JOURNAL OF VASCULAR SURGERY, 64(3), 811-U367. doi:10.1016/j.jvs.2016.05.065

Barrett, M. J., Koeppel, A. F., Flanigan, J. L., Turner, S. D., & Worrall, B. B. (2016). Investigation of Genetic Variants Associated with Alzheimer Disease in Parkinson Disease Cognition. JOURNAL OF PARKINSONS DISEASE, 6(1), 119-124. doi:10.3233/JPD-150706

Ehrlich, M. E., Turner, H. L., Currie, L. J., Wintermark, M., Worrall, B. B., & Southerland, A. M. (2016). Safety of Computed Tomographic Angiography in the Evaluation of Patients With Acute Stroke A Single-Center Experience. STROKE, 47(8), 2045-2050. doi:10.1161/STROKEAHA.116.013973

Pasterkamp, G., van der Laan, S. W., Haitjema, S., Asl, H. F., Siemelink, M. A., Bezemer, T., . . . Asselbergs, F. W. (2016). Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(6), 1240-+. doi:10.1161/ATVBAHA.115.306958

Malik, R., Traylor, M., Pulit, S. L., Bevan, S., Hopewell, J. C., Holliday, E. G., . . . Dichgans, M. (2016). Low-frequency and common genetic variation in ischemic stroke The METASTROKE collaboration. NEUROLOGY, 86(13), 1217-1226. doi:10.1212/WNL.0000000000002528

Hinds, D. A., Buil, A., Ziemek, D., Martinez-Perez, A., Malik, R., Folkersen, L., . . . Sabater-Lleal, M. (2016). Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. HUMAN MOLECULAR GENETICS, 25(9), 1867-1874. doi:10.1093/hmg/ddw037

Hagenaars, S. P., Harris, S. E., Davies, G., Hill, W. D., Liewald, D. C. M., Ritchie, S. J., . . . Deary, I. J. (2016). Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112151) and 24 GWAS consortia. MOLECULAR PSYCHIATRY, 21(11), 1624-1632. doi:10.1038/mp.2015.225

Cheng, Y. -C., Stanne, T. M., Giese, A. -K., Ho, W. K., Traylor, M., Amouyel, P., . . . Mitchell, B. D. (2016). Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. STROKE, 47(2), 307-+. doi:10.1161/STROKEAHA.115.011328

Tran, T., Cotlarciuc, I., Yadav, S., Hasan, N., Bentley, P., Levi, C., . . . Sharma, P. (2016). Candidate-gene analysis of white matter hyperintensities on neuroimaging. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 87(3), 260-266. doi:10.1136/jnnp-2014-309685

2015

Williams, S. R., Hsu, F. -C., Keene, K. L., Chen, W. -M., Nelson, S., Southerland, A. M., . . . Worrall, B. B. (2016). Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. NEUROLOGY, 86(4), 351-359. doi:10.1212/WNL.0000000000002319

Harris, S. E., Malik, R., Marioni, R., Campbell, A., Seshadri, S., Worrall, B. B., . . . Deary, I. J. (2016). Polygenic risk of ischemic stroke is associated with cognitive ability. NEUROLOGY, 86(7), 611-618. doi:10.1212/WNL.0000000000002306

Rosand, J., Mitchell, B. D., Ay, H., de Bakker, P. I. W., Gwinn, K., Kittner, S. J., . . . Worrall, B. B. (2016). Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. LANCET NEUROLOGY, 15(2), 174-184. doi:10.1016/S1474-4422(15)00338-5

Traylor, M., Zhang, C. R., Adib-Samii, P., Devan, W. J., Parsons, O. E., Lanfranconi, S., . . . Rost, N. (2016). Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. NEUROLOGY, 86(2), 146-153. doi:10.1212/WNL.0000000000002263

Lippman, J. M., Smith, S. N. C., McMurry, T. L., Sutton, Z. G., Gunnell, B. S., Cote, J., . . . Southerland, A. M. (2016). Mobile Telestroke During Ambulance Transport Is Feasible in a Rural EMS Setting: The iTREAT Study. TELEMEDICINE AND E-HEALTH, 22(6), 507-513. doi:10.1089/tmj.2015.0155

Chen, C. -J., Ding, D., Starke, R. M., Mehndiratta, P., Crowley, R. W., Liu, K. C., . . . Worrall, B. B. (2015). Endovascular vs medical management of acute ischemic stroke. NEUROLOGY, 85(22), 1980-1990. doi:10.1212/WNL.0000000000002176

Dhamija, R., Schiff, D., Lopes, M. B. S., Jen, J. C., Lin, D. D., & Worrall, B. B. (2015). Evolution of brain lesions in a patient with TREX1 cerebroretinal vasculopathy. NEUROLOGY, 85(18), 1633-1634. doi:10.1212/WNL.0000000000002092

Marceau, R., Lu, W., Holloway, S., Sale, M. M., Worrall, B. B., Williams, S. R., . . . Tzeng, J. -Y. (2015). A Fast Multiple-Kernel Method With Applications to Detect Gene-Environment Interaction. GENETIC EPIDEMIOLOGY, 39(6), 456-468. doi:10.1002/gepi.21909

Radmanesh, F., Falcone, G. J., Anderson, C. D., McWilliams, D., Devan, W. J., Brown, W. M., . . . Rosand, J. (2015). Rare Coding Variation and Risk of Intracerebral Hemorrhage. STROKE, 46(8), 2299-2301. doi:10.1161/STROKEAHA.115.009838

Carty, C. L., Keene, K. L., Cheng, Y. -C., Meschia, J. F., Chen, W. -M., Nalls, M., . . . Fornage, M. (2015). Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. STROKE, 46(8), 2063-2068. doi:10.1161/STROKEAHA.115.009044

Malik, R., Freilinger, T., Anttila, V., Vander Heiden, J., Traylor, M., de Vries, B., . . . Dichgans, M. (2015). Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. NEUROLOGY, 84(21), 2132-2145. doi:10.1212/WNL.0000000000001606

Rannikmaee, K., Davies, G., Thomson, P. A., Bevan, S., Devan, W. J., Falcone, G. J., . . . Sudlow, C. L. M. (2015). Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. NEUROLOGY, 84(9), 918-926. doi:10.1212/WNL.0000000000001309

Martini, S., Williams, S., Moretti, P., Woo, D., & Worrall, B. (2015). A molecular/genetic approach to cerebral small-vessel disease: Beyond aging and hypertension. Brain Circulation, 1(1), 79. doi:10.4103/2394-8108.166376

Hanscombe, K. B., Traylor, M., Hysi, P. G., Bevan, S., Dichgans, M., Rothwell, P. M., . . . Lewis, C. M. (2015). Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke. STROKE, 46(8), 2069-2074. doi:10.1161/STROKEAHA.115.009387

Debette, S., Compter, A., Labeyrie, M. -A., Uyttenboogaart, M., Metso, T. M., Majersik, J. J., . . . Bousser, M. -G. (2015). Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. LANCET NEUROLOGY, 14(6), 640-654. doi:10.1016/S1474-4422(15)00009-5

Auer, P. L., Nalls, M., Meschia, J. F., Worrall, B. B., Longstreth, W. T. J., Seshadri, S., . . . Rich, S. S. (2015). Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke The NHLBI Exome Sequence Project. JAMA NEUROLOGY, 72(7), 781-788. doi:10.1001/jamaneurol.2015.0582

Holliday, E. G., Traylor, M., Malik, R., Bevan, S., Falcone, G., Hopewell, J. C., . . . Wray, N. R. (2015). Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke. STROKE, 46(3), 615-+. doi:10.1161/STROKEAHA.114.007930

Mehndiratta, P., Chapman Smith, S., & Worrall, B. B. (2015). Etiologic stroke subtypes: updated definition and efficient workup strategies.. Current treatment options in cardiovascular medicine, 17(1), 357. doi:10.1007/s11936-014-0357-7

Majersik, J. J., Cole, J. W., Golledge, J., Rost, N. S., Chan, Y. -F. Y., Gurol, M. E., . . . Maguire, J. (2015). Recommendations From the International Stroke Genetics Consortium, Part 1 Standardized Phenotypic Data Collection. STROKE, 46(1), 279-+. doi:10.1161/STROKEAHA.114.006839

2014

Debette, S., Kamatani, Y., Metso, T. M., Kloss, M., Chauhan, G., Engelter, S. T., . . . Jungehuelsing, J. (2015). Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. NATURE GENETICS, 47(1), 78-+. doi:10.1038/ng.3154

McArdle, P. F., Kittner, S. J., Ay, H., Brown, R. D. J., Meschia, J. F., Rundek, T., . . . Worrall, B. B. (2014). Agreement between TOAST and CCS ischemic stroke classification The NINDS SiGN Study. NEUROLOGY, 83(18), 1653-1660. doi:10.1212/WNL.0000000000000942

Foroud, T., Lai, D., Koller, D., van't Hof, F., Kurki, M. I., Anderson, C. S., . . . Broderick, J. (2014). Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7. STROKE, 45(11), 3194-3199. doi:10.1161/STROKEAHA.114.006096

Falcone, G. J., Radmanesh, F., Brouwers, H. B., Battey, T. W. K., Devan, W. J., Valant, V., . . . Anderson, C. D. (2014). APOE ε variants increase risk of warfarin-related intracerebral hemorrhage. NEUROLOGY, 83(13), 1139-1146. doi:10.1212/WNL.0000000000000816

Woo, D., Falcone, G. J., Devan, W. J., Brown, W. M., Biffi, A., Howard, T. D., . . . Rosand, J. (2014). Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage. AMERICAN JOURNAL OF HUMAN GENETICS, 94(4), 511-521. doi:10.1016/j.ajhg.2014.02.012

Falcone, G. J., Woo, D., Brown, W. M., Tirschwell, D. L., Selim, M., Brown, D. L., . . . Rosand, J. (2014). Meta-Analysis of Genome-Wide Association Studies Identifies 1q22 as a Novel Susceptibility Locus for Intracerebral Hemorrhage. CEREBROVASCULAR DISEASES, 37, 144.

Lindgren, A., Bevan, S., Fernandez-Cadenas, I., Jern, C., Jimenez-Conde, J., Lee, J. -M., . . . Worrall, B. B. (2014). GISCOME - Genetics of Ischaemic Stroke Outcome study. CEREBROVASCULAR DISEASES, 37, 285.

Ay, H., Arsava, E. M., Andsberg, G., Benner, T., Brown, R. D. J., Chapman, S. N., . . . Meschia, J. F. (2014). Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network. STROKE, 45(12), 3589-+. doi:10.1161/STROKEAHA.114.007362

Kilarski, L. L., Achterberg, S., Devan, W. J., Traylor, M., Malik, R., Lindgren, A., . . . Bevan, S. (2014). Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. NEUROLOGY, 83(8), 678-685. doi:10.1212/WNL.0000000000000707

Zhou, Q., Yang, D., Ombrello, A. K., Zavialov, A. V., Toro, C., Zavialov, A. V., . . . Aksentijevich, I. (2014). Early- Onset Stroke and Vasculopathy Associated with Mutations in ADA2. NEW ENGLAND JOURNAL OF MEDICINE, 370(10), 911-920. doi:10.1056/NEJMoa1307361

Maguire, J., Lindgren, A., Bevan, S., Fernandez-Cadenas, I., Hankey, G., Jern, C., . . . Worrall, B. (2014). GISCOME - Genetic Influences on Ischaemic Stroke Functional Outcome: A genome wide association study. INTERNATIONAL JOURNAL OF STROKE, 9, 23.

Bonds, D. E., Harrington, M., Worrall, B. B., Bertoni, A. G., Eaton, C. B., Hsia, J., . . . Chew, E. Y. (2014). Effect of Long-Chain Ï-3 Fatty Acids and Lutein plus Zeaxanthin Supplements on Cardiovascular Outcomes Results of the Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial. JAMA INTERNAL MEDICINE, 174(5), 763-771. doi:10.1001/jamainternmed.2014.328

Huang, J., Huffman, J. E., Yamkauchi, M., Trompet, S., Asselbergs, F. W., Sabater-Lleal, M., . . . O'Donnell, C. J. (2014). Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(5), 1093-1101. doi:10.1161/ATVBAHA.113.302088

Williams, S. R., Yang, Q., Chen, F., Liu, X., Keene, K. L., Jacques, P., . . . Sale, M. M. (2014). Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke. PLOS GENETICS, 10(3). doi:10.1371/journal.pgen.1004214

Kim, D. S., Crosslin, D. R., Auer, P. L., Suzuki, S. M., Marsillach, J., Burt, A. A., . . . Jarvik, G. P. (2014). Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. JOURNAL OF LIPID RESEARCH, 55(6), 1173-1178. doi:10.1194/jlr.P049247

Keene, K. L., Chen, W. -M., Chen, F., Williams, S. R., Elkhatib, S. D., Hsu, F. -C., . . . Sale, M. M. (2014). Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the Vitamin Intervention for Stroke Prevention (VISP) trial. FRONTIERS IN PUBLIC HEALTH, 2. doi:10.3389/fpubh.2014.00112

Cotlarciuc, I., Malik, R., Holliday, E. G., Ahmadi, K. R., Pare, G., Psaty, B. M., . . . Sharma, P. (2014). Effect of Genetic Variants Associated With Plasma Homocysteine Levels on Stroke Risk. STROKE, 45(7), 1920-1924. doi:10.1161/STROKEAHA.114.005208

Barrett, M. J., Koeppel, A. F., Turner, S. D., & Worrall, B. B. (2014). Investigation of genetic variants associated with Alzheimer disease and vascular dementia in Parkinson's disease cognition. MOVEMENT DISORDERS, 29, S337.

2013

Woo, D., Rosand, J., Kidwell, C., McCauley, J. L., Osborne, J., Brown, M. W., . . . Langefeld, C. D. (2013). The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study Protocol. STROKE, 44(10), E120-E125. doi:10.1161/STROKEAHA.113.002332

Meschia, J. F., Worrall, B. B., Brown, R. D., Ay, H., McArdle, P. F., Rundek, T., & Kittner, S. J. (2013). NINDS stroke genetics network (SiGN) experience with the causative classification system. INTERNATIONAL JOURNAL OF STROKE, 8(4), E9. doi:10.1111/j.1747-4949.2012.00944.x

Ross, O. A., Soto-Ortolaza, A. I., Heckman, M. G., Verbeeck, C., Serie, D. J., Rayaprolu, S., . . . Meschia, J. F. (2013). NOTCH3 Variants and Risk of Ischemic Stroke. PLOS ONE, 8(9). doi:10.1371/journal.pone.0075035

Ay, H., Arsava, E. M., Brown, R., Kittner, S., McArdle, P., Rosand, J., . . . Meschia, J. (2013). Etiologic Stroke Subtypes in the NINDS Stroke Genetics Network Study. NEUROLOGY, 80.

Katsnelson, M. J., Rundek, T., Sacco, R., Worrall, B. B., Meschia, J. F., Ay, H., . . . Kittner, S. (2013). Classification of Stroke Sub-types by Race-Ethnicities in the Stroke Genetics Network with Causative Classification System. STROKE, 44(2).

Devan, W. J., Falcone, G. J., Anderson, C. D., Jagiella, J. M., Schmidt, H., Hansen, B. M., . . . Biffi, A. (2013). Heritability Estimates Identify a Substantial Genetic Contribution to Risk and Outcome of Intracerebral Hemorrhage. STROKE, 44(6), 1578-U191. doi:10.1161/STROKEAHA.111.000089

Falcone, G. J., Biffi, A., Devan, W. J., Brouwers, H. B., Anderson, C. D., Valant, V., . . . Rosand, J. (2013). Burden of Blood Pressure-Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage. STROKE, 44(2), 321-+. doi:10.1161/STROKEAHA.112.675181

Anderson, C. D., Biffi, A., Nalls, M. A., Devan, W. J., Schwab, K., Ayres, A. M., . . . Rosand, J. (2013). Common Variants Within Oxidative Phosphorylation Genes Influence Risk of Ischemic Stroke and Intracerebral Hemorrhage. STROKE, 44(3), 612-+. doi:10.1161/STROKEAHA.112.672089

Khan, T. A., Shah, T., Prieto, D., Zhang, W., Price, J., Fowkes, G. R., . . . Casas, J. P. (2013). Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 42(2), 475-492. doi:10.1093/ije/dyt034

Biffi, A., Anderson, C. D., Falcone, G. J., Kissela, B., Norrving, B., Tirschwell, D. L., . . . Rosand, J. (2013). Novel Insights Into the Genetics of Intracerebral Hemorrhage. STROKE, 44(6), S137. doi:10.1161/STROKEAHA.113.001912

Anderson, C., Biffi, A., Nalls, M., Devan, W., Schwab, K., Ayres, A., . . . Rosand, J. (2013). Common Variants within Oxidative Phosphorylation Genes Influence Risk of Ischemic Stroke and Intracerebral Hemorrhage. NEUROLOGY, 80.

Anderson, C., Biffi, A., Nalls, M., Devan, W., Schwab, K., Ayres, A., . . . Rosand, J. (2013). Common Variants within Oxidative Phosphorylation Genes Influence Risk of Ischemic Stroke and Intracerebral Hemorrhage. NEUROLOGY, 80.

Sheth, K. N., Martini, S. R., Tirschwell, D. L., Becker, K. J., Worrall, B. B., James, M. L., . . . Woo, D. (2013). Withdrawal of Care in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study. STROKE, 44(2).

Adib-Samii, P., Rost, N., Traylor, M., Devan, W., Biffi, A., Lanfranconi, S., . . . Markus, H. S. (2013). 17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status. STROKE, 44(6), 1609-+. doi:10.1161/STROKEAHA.113.679936

Bookman, E. B., Din-Lovinescu, C., Worrall, B. B., Manolio, T. A., Bennett, S. N., Laurie, C., . . . Chen, D. T. (2013). Incidental genetic findings in randomized clinical trials: recommendations from the Genomics and Randomized Trials Network (GARNET). GENOME MEDICINE, 5. doi:10.1186/gm411

Yadav, S., Cotlarciuc, I., Munroe, P. B., Khan, M. S., Nalls, M. A., Bevan, S., . . . Sharma, P. (2013). Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke. STROKE, 44(10), 2703-2709. doi:10.1161/STROKEAHA.113.002186

Worrall, B. B., & Eckerle, B. (2013). Pairing Neuropathology with Genetics: A New Tool for Parsing Cerebrovascular Disease. CEREBROVASCULAR DISEASES, 36(3), 189. doi:10.1159/000353726

Meschia, J. F., Arnett, D. K., Ay, H., Brown, R. D., Benavente, O. R., Cole, J. W., . . . Kittner, S. J. (2013). Stroke Genetics Network (SiGN) Study Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes. STROKE, 44(10), 2694-2702. doi:10.1161/STROKEAHA.113.001857

Southerland, A. M., Meschia, J. F., & Worrall, B. B. (2013). Shared associations of nonatherosclerotic, large-vessel, cerebrovascular arteriopathies: considering intracranial aneurysms, cervical artery dissection, moyamoya disease and fibromuscular dysplasia. CURRENT OPINION IN NEUROLOGY, 26(1), 13-28. doi:10.1097/WCO.0b013e32835c607f

2012

Holliday, E. G., Maguire, J. M., Evans, T. -J., Koblar, S. A., Jannes, J., Sturm, J. W., . . . Attia, J. (2012). Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. NATURE GENETICS, 44(10), 1147-+. doi:10.1038/ng.2397

Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., . . . Markus, H. S. (2012). Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. NATURE GENETICS, 44(3), 328-U141. doi:10.1038/ng.1081

Biffi, A., Shulman, J. M., Jagiella, J. M., Cortellini, L., Ayres, A. M., Schwab, K., . . . Rosand, J. (2012). Genetic variation at CR1 increases risk of cerebral amyloid angiopathy. NEUROLOGY, 78(5), 334-341. doi:10.1212/WNL.0b013e3182452b40

Traylor, M., Farrall, M., Holliday, E. G., Sudlow, C., Hopewell, J. C., Cheng, Y. -C., . . . Markus, H. S. (2012). Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. LANCET NEUROLOGY, 11(11), 951-962. doi:10.1016/S1474-4422(12)70234-X

Cheng, Y. -C., Anderson, C. D., Bione, S., Keene, K., Maguire, J. M., Nalls, M., . . . Mitchell, B. D. (2012). Are Myocardial Infarction-Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke?. STROKE, 43(4), 980-U143. doi:10.1161/STROKEAHA.111.632075

Foroud, T., Koller, D. L., Lai, D., Sauerbeck, L., Anderson, C., Ko, N., . . . Broderick, J. P. (2012). Genome-Wide Association Study of Intracranial Aneurysms Confirms Role of Anril and SOX17 in Disease Risk. STROKE, 43(11), 2846-U134. doi:10.1161/STROKEAHA.112.656397

Falcone, G. J., Biffi, A., Devan, W. J., Jagiella, J. M., Schmidt, H., Kissela, B., . . . Rosand, J. (2012). Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage. STROKE, 43(11), 2877-U183. doi:10.1161/STROKEAHA.112.659755

Metso, A. J., Metso, T. M., Debette, S., Dallongeville, J., Lyrer, P. A., Pezzini, A., . . . Tatlisumak, T. (2012). Gender and cervical artery dissection. EUROPEAN JOURNAL OF NEUROLOGY, 19(4), 594-602. doi:10.1111/j.1468-1331.2011.03586.x

2011

Cheng, Y. -C., O'Connell, J. R., Cole, J. W., Stine, O. C., Dueker, N., McArdle, P. F., . . . Mitchell, B. D. (2011). Genome-Wide Association Analysis of Ischemic Stroke in Young Adults. G3-GENES GENOMES GENETICS, 1(6), 505-513. doi:10.1534/g3.111.001164

Zhang, X., Meng, H., Blaivas, M., Rushing, E. J., Moore, B. E., Schwartz, J., . . . Wang, M. M. (2012). von Willebrand Factor Permeates Small Vessels in CADASIL and Inhibits Smooth Muscle Gene Expression. TRANSLATIONAL STROKE RESEARCH, 3(1), 138-145. doi:10.1007/s12975-011-0112-2

Hsu, F. -C., Sides, E. G., Mychaleckyj, J. C., Worrall, B. B., Elias, G. A., Liu, Y., . . . Sale, M. M. (2011). Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk. NEUROLOGY, 77(16), 1543-1550. doi:10.1212/WNL.0b013e318233b1f9

Tzeng, J. -Y., Zhang, D., Pongpanich, M., Smith, C., McCarthy, M. I., Sale, M. M., . . . Sullivan, P. F. (2011). Studying Gene and Gene-Environment Effects of Uncommon and Common Variants on Continuous Traits: A Marker-Set Approach Using Gene-Trait Similarity Regression. AMERICAN JOURNAL OF HUMAN GENETICS, 89(2), 277-288. doi:10.1016/j.ajhg.2011.07.007

Biffi, A., Anderson, C. D., Jagiella, J. M., Schmidt, H., Kissela, B., Hansen, B. M., . . . Rosand, J. (2011). APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. LANCET NEUROLOGY, 10(8), 702-709. doi:10.1016/S1474-4422(11)70148-X

Meschia, J. F., Worrall, B. B., & Rich, S. S. (2011). Genetic susceptibility to ischemic stroke. NATURE REVIEWS NEUROLOGY, 7(7), 369-378. doi:10.1038/nrneurol.2011.80

Meschia, J. F., Nalls, M., Matarin, M., Brott, T. G., Brown, R. D. J., Hardy, J., . . . Worrall, B. B. (2011). Siblings With Ischemic Stroke Study Results of a Genome-Wide Scan for Stroke Loci. STROKE, 42(10), 2726-2U83. doi:10.1161/STROKEAHA.111.620484

Meschia, J. F., Singleton, A., Nalls, M. A., Rich, S. S., Sharma, P., Ferrucci, L., . . . Worrall, B. B. (2011). Genomic Risk Profiling of Ischemic Stroke: Results of an International Genome-Wide Association Meta-Analysis. PLOS ONE, 6(9). doi:10.1371/journal.pone.0023161

Anderson, C. D., Biffi, A., Rahman, R., Ross, O. A., Jagiella, J. M., Kissela, B., . . . Rosand, J. (2011). Common Mitochondrial Sequence Variants in Ischemic Stroke. STROKE, 42(3), E102-E103.

Brown, W. M., Biffi, A., Jagiella, J., Comeau, M., Cortellini, L., Woo, J. G., . . . Rosand, J. (2011). Genome Wide Association Study of Intracerebral Hemorrhage. STROKE, 42(3), E218-E219.

Holmes, M. V., Newcombe, P., Hubacek, J. A., Sofat, R., Ricketts, S. L., Cooper, J., . . . Casas, J. P. (2011). Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. LANCET, 378(9791), 584-594. doi:10.1016/S0140-6736(11)60872-6

Solorzano, G., Chen, F., Mychaleckyj, J. C., Chen, W. -M., Hsu, F. -C., Sale, M., & Worrall, B. B. (2011). Antihypertensive Class And Stroke Recurrence: An Analysis Of The VISP Trial. STROKE, 42(3), E348.

2010

Rost, N. S., Rahman, R. M., Biffi, A., Smith, E. E., Kanakis, A., Fitzpatrick, K., . . . Rosand, J. (2010). White matter hyperintensity volume is increased in small vessel stroke subtypes. NEUROLOGY, 75(19), 1670-1677. doi:10.1212/WNL.0b013e3181fc279a

Arsava, E. M., Ballabio, E., Benner, T., Cole, J. W., Delgado-Martinez, M. P., Dichgans, M., . . . Ay, H. (2010). The Causative Classification of Stroke system An international reliability and optimization study. NEUROLOGY, 75(14), 1277-1284. doi:10.1212/WNL.0b013e3181f612ce

Anderson, C. D., Biffi, A., Rahman, R., Ross, O. A., Jagiella, J. M., Kissela, B., . . . Rosand, J. (2011). Common Mitochondrial Sequence Variants in Ischemic Stroke. ANNALS OF NEUROLOGY, 69(3), 471-480. doi:10.1002/ana.22108

Schwab, K. M., Chen, D. T., Brown, D. L., Majersik, J. J., Selim, M. H., Silliman, S. L., . . . Worrall, B. B. (2010). Phenotypic Characteristics by Consent Status: Comparison of Self-consent, Proxy-consent, and Waiver of Consent in the Genetics of Cerebral Hemorrhage in Anticoagulation (GOCHA) Study. STROKE, 41(4), E337-E338.

Jones, J. E., Koirala, T. R., Nadler, J., Gerrity, R., & Worrall, B. B. (2010). Inflammatory Mechanisms in Small Vessel Cerebrovascular Disease in a Novel Porcine Model. STROKE, 41(4), E351.

Patel, R. K., Elias, G. A., Hsu, F. -C., Mychaleckyj, J. C., Chen, W. -M., Worrall, B. B., & Sale, M. M. (2010). Investigation of Recurrent Stroke Risk in the Vitamin Intervention for Stroke Prevention (VISP) Trial Suggests Different Genetic Influences on Prevalent and Incident Stroke. STROKE, 41(4), E335.

Koirala, T., Posenau, J. T., Gerrity, R. G., Nadler, J. L., & Worrall, B. B. (2010). Inflammatory Mediators in Large Vessel Cerebrovascular Atherosclerosis in Diabetic Swine: A Quantitative Expression Analysis. STROKE, 41(4), E278.

Elias, G. A., Patel, R. K., Chen, W. -M., Mychaleckyj, J. C., Hsu, F. -C., Worrall, B. B., & Sale, M. M. (2010). Association of a Transcobalamin 2 (TCN2) Variant Located in the 3UTR With Post-stroke Homocysteine Level in Subjects From the Vitamin Intervention for Stroke Prevention Trial. STROKE, 41(4), E335.

Biffi, A., Sonni, A., Anderson, C. D., Kissela, B., Jagiella, J. M., Schmidt, H., . . . Rosand, J. (2010). Variants at APOE Influence Risk of Deep and Lobar Intracerebral Hemorrhage. ANNALS OF NEUROLOGY, 68(6), 934-943. doi:10.1002/ana.22134

Li, S. S., Ferrante, E. A., Annex, B. H., Farber, C. R., & Worrall, B. B. (2010). Cerebral RNA Expression Variation Between Inbred Mouse Strains Resistant and Susceptible to Cerebral Ischemia: Testing Novel Human Candidates. STROKE, 41(4), E231-E232.

Cohn, W. F., Ropka, M. E., Pelletier, S. L., Barrett, J. R., Kinzie, M. B., Harrison, M. B., . . . Knaus, W. A. (2010). Health Heritage©, a Web-Based Tool for the Collection and Assessment of Family Health History: Initial User Experience and Analytic Validity. PUBLIC HEALTH GENOMICS, 13(7-8), 477-491. doi:10.1159/000294415