Leveraging Nature’s Success: Lessons from Modifiers of Marfan Syndrome and Related Aneurysm Conditions Dysregulation of TGFβ signaling has been implicated in many disease states including Marfan syndrome (MFS), a condition caused by deficiency of the extracellular matrix protein fibrillin-1. Many … Read More
Endothelium at the Interface of Lipid Metabolism, Vascular Function and Disease The endothelium is the key cell type at the interface of circulating lipids and the vessels wall. New insights into how lipids and inflammatory signaling impacts endothelial cell functions … Read More
Understanding Vascular Growth Kinetics At the structural level, the vascular system is a network of interconnected tubes responsible for delivering oxygen and nutrients throughout the body. While accurate, this portrayal understates the complexities inherent to its functionality. Beyond mere transportation, … Read More
Dichotomous Roles of Inflammation in Atherosclerosis Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the underlying cause of heart attacks and stroke which are the leading cause of death in the United States and worldwide. Whereas … Read More
