Monica Lee, PhD
March 19 @ 11:00 am – 12:00 pm
Deciphering the role of nucleoporin93 (Nup93) in endothelial and vascular function
The vascular network is uniquely subject to mechanical changes and hence capable of perceiving various biophysical forces. While emerging studies identify nucleoskeletal elements (i.e. nuclear lamina) and linker of nucleoskeleton and cytoskeleton (LINC) complex proteins as key regulators of endothelial cell function, the role of nuclear pore complex (NPC) proteins (i.e. nucleoporins) remains elusive. This seminar will detail the cellular consequences of nucleoporin93 (Nup93) loss, a natural outcome of endothelial aging, and the vascular ramifications of endothelial Nup93 loss using novel mouse models.
Assistant Professor, Department of Physiology and Biophysics, University of Illinois Chicago, Chicago Illinois