Brant Isakson
- Email: brant@virginia.edu
- Phone: 4-2093
- Website: http://cvrc.virginia.edu/isakson
Primary Appointment
Professor, Molecular Physiology and Biological Physics
Education
- PhD, University of Wyoming
Research Disciplines
Biotechnology, Cardiovascular Biology, Metabolism, Molecular Pharmacology, Physiology, Translational Science
Research Interests
Translating our discoveries in the microcirculation to tangible benefits in patients.
Research Description
Personal Statement
Training
- Basic Cardiovascular Research Training Grant
- Biotechnology Training Grant
- Training in Cell and Molecular Biology
- Training in Molecular Biophysics
- Training in the Pharmacological Sciences
Selected Publications
2024
Dunaway, L. S., Loeb, S. A., Petrillo, S., Tolosano, E., & Isakson, B. E. (2024). Heme metabolism in non-erythroid cells.. J Biol Chem, 107132. doi:10.1016/j.jbc.2024.107132
Dunaway, L. S., Luse, M. A., Nyshadham, S., Bulut, G., Alencar, G. F., Chavkin, N. W., . . . Isakson, B. E. (2024). Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium.. Physiological genomics, 56(2), 113-127. doi:10.1152/physiolgenomics.00109.2023
Wolpe, A. G., Luse, M. A., Baryiames, C., Schug, W. J., Wolpe, J. B., Johnstone, S. R., . . . Isakson, B. E. (2024). Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.. Science signaling, 17(821), eadg2622. doi:10.1126/scisignal.adg2622
2023
Pavelec, C. M., Young, A. P., Luviano, H. L., Orrell, E. E., Poudel, N., Wolpe, A. G., . . . Leitinger, N. (2023). Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure.. bioRxiv. doi:10.1101/2023.12.29.573679
Luse, M. A., Jackson, M. G., Juskiewicz, Z. J., & Isakson, B. E. (2023). Physiological functions of caveolae in endothelium. CURRENT OPINION IN PHYSIOLOGY, 35. doi:10.1016/j.cophys.2023.100701
Sveeggen, T. M., Isakson, B. E., Straub, A. C., & Bagher, P. (2023). Bedding as a variable affecting fasting blood glucose and vascular physiology in mice. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 325(2), H338-H345. doi:10.1152/ajpheart.00168.2023
Shah, S. A., Reagan, C. E., Bresticker, J. E., Wolpe, A. G., Good, M. E., Macal, E. H., . . . Epstein, F. H. (2023). Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition. JACC-BASIC TO TRANSLATIONAL SCIENCE, 8(5), 501-514. doi:10.1016/j.jacbts.2022.11.005
Ruddiman, C. A., Peckham, R., Luse, M. A., Chen, Y. -L., Kuppusamy, M., Corliss, B. A., . . . Isakson, B. E. (2023). Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1. JCI INSIGHT, 8(9). doi:10.1172/jci.insight.165715
Koval, M., Schug, W. J., & Isakson, B. E. (2023). Pharmacology of pannexin channels. CURRENT OPINION IN PHARMACOLOGY, 69. doi:10.1016/j.coph.2023.102359
Ragland, T. J., Heiston, E. M., Ballantyne, A., Stewart, N. R., La Salvia, S., Musante, L., . . . Malin, S. K. (2023). Extracellular vesicles and insulin-mediated vascular function in metabolic syndrome. PHYSIOLOGICAL REPORTS, 11(1). doi:10.14814/phy2.15530
Dunaway, L. S., Billaud, M., Macal, E., Good, M. E., Medina, C. B., Lorenz, U., . . . Isakson, B. E. (2023). Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve-Induced Vasoconstriction. HYPERTENSION, 80(2), 416-425. doi:10.1161/HYPERTENSIONAHA.122.20280
Chu, P. -L., Gigliotti, J. C., Cechova, S., Bodonyi-Kovacs, G., Wang, Y. T., Chen, L., . . . Le, T. H. (2023). Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 324(1), F30-F42. doi:10.1152/ajprenal.00176.2022
Baldwin, S. N., Forrester, E. A., Homer, N. Z. M., Andrew, R., Barrese, V., Stott, J. B., . . . Greenwood, I. A. (2023). Marked oestrous cycle-dependent regulation of rat arterial KV7.4 channels driven by GPER1. BRITISH JOURNAL OF PHARMACOLOGY, 180(2), 174-193. doi:10.1111/bph.15947
2022
Luse, M. A., Pavelic, C., Tessema, R., Cochran, J., Minshall, R. D., Leitinger, N., & Isakson, B. E. (2022). Genetic deletion of endothelial Caveolin-1 is protective against metabolic disease.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36 Suppl 1. doi:10.1096/fasebj.2022.36.s1.r5416
Keller, T. C. S., Lechauve, C., Keller, A. S., Broseghini-Filho, G. B., Butcher, J. T., Page, H. R. A., . . . Isakson, B. E. (2022). Endothelial alpha globin is a nitrite reductase. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34154-3
Luse, M. A., Kruger, N., Good, M. E., Biwer, L. A., Serbulea, V., Salamon, A., . . . Isakson, B. E. (2022). Smooth muscle cell FTO regulates contractile function. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 323(6), H1212-H1220. doi:10.1152/ajpheart.00427.2022
King, D. R., Sedovy, M. W., Eaton, X., Dunaway, L. S., Good, M. E., Isakson, B. E., & Johnstone, S. R. (2022). Cell-to-cell Communication in the Resistance Vasculature. COMPREHENSIVE PHYSIOLOGY, 12(4), 3833-3867. doi:10.1002/cphy.c210040
Granade, M. E., Hargett, S. R., Lank, D. S., Lemke, M. C., Luse, M. A., Isakson, B. E., . . . Harris, T. E. (2022). Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation. MOLECULAR METABOLISM, 63. doi:10.1016/j.molmet.2022.101543
Cortese-Krott, M. M., Suvorava, T., Leo, F., Heuser, S. K., LoBue, A., Li, J., . . . Kelm, M. (2022). Red blood cell eNOS is cardioprotective in acute myocardial infarction. REDOX BIOLOGY, 54. doi:10.1016/j.redox.2022.102370
Wolpe, A. G., Luse, M. A., Johnstone, S. R., Xue, J., Sabapathy, V., Wakefield, B., . . . Isakson, B. E. (2022). Endothelial Pannexin 3-B Cell Lymphoma-6 Interactions Protect Against Oxidative Stress. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R5405
Molina, S. A., Maier-Begandt, D., Isakson, B. E., & Koval, M. (2022). Electrophysiological Measurements of Isolated Blood Vessels. BIO-PROTOCOL, 12(6). doi:10.21769/BioProtoc.4359
Filiberto, A. C., Spinosa, M. D., Elder, C. T., Su, G., Leroy, V., Ladd, Z., . . . Sharma, A. K. (2022). Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-29233-4
Wenceslau, C. F., McCarthy, C. G., Earley, S., England, S. K., Filosa, J. A., Goulopoulou, S., . . . Webb, R. C. (2022). Reply to Boedtkjer and Aalkjaer. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(4), H687-H688. doi:10.1152/ajpheart.00117.2022
Wenceslau, C. F., McCarthy, C. G., Earley, S., England, S. K., Filosa, J. A., Goulopoulou, S., . . . Webb, R. C. (2022). Reply to De Mey et al.. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(4), H683-H684. doi:10.1152/ajpheart.00086.2022
Kiger, L., Keith, J., Freiwan, A., Fernandez, A. G., Tillman, H., Isakson, B. E., . . . Lechauve, C. (2022). Redox-Regulation of α-Globin in Vascular Physiology. ANTIOXIDANTS, 11(1). doi:10.3390/antiox11010159
Grimmer, B., Krauszman, A., Hu, X., Kabir, G., Connelly, K. A., Li, M., . . . Kuebler, W. M. (2022). Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction. CARDIOVASCULAR RESEARCH, 118(11), 2535-2547. doi:10.1093/cvr/cvab326
Keller, T. C. S., Lechauve, C., Keller, A. S., Brooks, S., Weiss, M. J., Columbus, L., . . . Isakson, B. E. (2022). THE ROLE OF GLOBINS IN CARDIOVASCULAR PHYSIOLOGY. PHYSIOLOGICAL REVIEWS, 102(2), 859-892. doi:10.1152/physrev.00037.2020
2021
King, D. R., Sedovy, M. W., Leng, X., Xue, J., Lamouille, S., Koval, M., . . . Johnstone, S. R. (2021). Mechanisms of Connexin Regulating Peptides. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19). doi:10.3390/ijms221910186
Daneva, Z., Ottolini, M., Chen, Y. L., Klimentova, E., Kuppusamy, M., Shah, S. A., . . . Sonkusare, S. K. (2021). Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. ELIFE, 10. doi:10.7554/eLife.67777
Bisht, K., Okojie, K. A., Sharma, K., Lentferink, D. H., Sun, Y. -Y., Chen, H. -R., . . . Eyo, U. B. (2021). Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25590-8
Koval, M., Cwiek, A., Carr, T., Good, M. E., Lohman, A. W., & Isakson, B. E. (2021). Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury. PURINERGIC SIGNALLING, 17(4), 521-531. doi:10.1007/s11302-021-09804-8
Leo, F., Suvorava, T., Heuser, S. K., Li, J., LoBue, A., Barbarino, F., . . . Cortese-Krott, M. M. (2021). Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure. CIRCULATION, 144(11), 870-889. doi:10.1161/CIRCULATIONAHA.120.049606
Wenceslau, C. F., McCarthy, C. G., Earley, S., England, S. K., Filosa, J. A., Goulopoulou, S., . . . Webb, R. C. (2021). Guidelines for the measurement of vascular function and structure in isolated arteries and veins. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 321(1), H77-H111. doi:10.1152/ajpheart.01021.2020
Daneva, Z., Marziano, C., Ottolini, M., Chen, Y. -L., Baker, T. M., Kuppusamy, M., . . . Sonkusare, S. K. (2021). Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(17). doi:10.1073/pnas.2023130118
Maier-Begandt, D., Comstra, H. S., Molina, S. A., Krueger, N., Ruddiman, C. A., Chen, Y. -L., . . . Isakson, B. E. (2021). A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability. SCIENCE SIGNALING, 14(672). doi:10.1126/scisignal.aba2940
Good, M. E., Young, A. P., Wolpe, A. G., Ma, M., Hall, P. J., Duffy, C. K., . . . Isakson, B. E. (2021). Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction. CIRCULATION RESEARCH, 128(8), 1211-1213. doi:10.1161/CIRCRESAHA.120.317272
Thakore, P., Alvarado, M. G., Ali, S., Mughal, A., Pires, P. W., Yamasaki, E., . . . Earley, S. (2021). Brain endothelial cell TRPA1 channels initiate neurovascular coupling. ELIFE, 10. doi:10.7554/eLife.63040
Wolpe, A. G., Ruddiman, C. A., Hall, P. J., & Isakson, B. E. (2021). Polarized Proteins in Endothelium and Their Contribution to Function. JOURNAL OF VASCULAR RESEARCH, 58(2), 65-91. doi:10.1159/000512618
2020
Luse, M. A., Heiston, E. M., Malin, S. K., & Isakson, B. E. (2020). Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium. CURRENT PHARMACEUTICAL DESIGN, 26(30), 3760-3767. doi:10.2174/1381612826666200721002735
Wischmann, P., Kuhn, V., Suvorava, T., Muessig, J. M., Fischer, J. W., Isakson, B. E., . . . Kelm, M. (2020). Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia. BASIC RESEARCH IN CARDIOLOGY, 115(4). doi:10.1007/s00395-020-0799-x
Bories, G. F. P., Yeudall, S., Serbulea, V., Fox, T. E., Isakson, B. E., & Leitinger, N. (2020). Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway. BLOOD, 136(13), 1535-1548. doi:10.1182/blood.2020004964
DeLalio, L. J., Masati, E., Mendu, S., Ruddiman, C. A., Yang, Y., Johnstone, S. R., . . . Isakson, B. E. (2020). Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis. KIDNEY INTERNATIONAL, 98(3), 630-644. doi:10.1016/j.kint.2020.04.041
Jankowski, J., Perry, H. M., Medina, C. B., Huang, L., Yao, J., Bajwa, A., . . . Okusa, M. D. (2020). Epithelial and endothelial pannexin1 channels mediate AKI (vol 29, pg 1887, 2018). JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 31(1), 231. doi:10.1681/ASN.2019111140
Garcia, V., Park, E. J., Siragusa, M., Frohlich, F., Haque, M. M., Pascale, J. V., . . . Sessa, W. C. (2020). Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(17), 9497-9507. doi:10.1073/pnas.1918761117
Yang, Y., Delalio, L. J., Best, A. K., Macal, E., Milstein, J., Donnelly, I., . . . Johnstone, S. R. (2020). Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium. JOURNAL OF IMMUNOLOGY, 204(11), 2995-3007. doi:10.4049/jimmunol.1901089
Biwer, L. A., Askew-Page, H. R., Hong, K., Milstein, J., Johnstone, S. R., Macal, E., . . . Isakson, B. E. (2020). Endothelial calreticulin deletion impairs endothelial function in aged mice. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 318(5), H1041-H1048. doi:10.1152/ajpheart.00586.2019
Leo, F., Krenz, T., Wolff, G., Weidenbach, M., Heiss, C., Kelm, M., . . . Cortese-Krott, M. M. (2020). Assessment of tissue perfusion and vascular function in mice by scanning laser Doppler perfusion imaging. BIOCHEMICAL PHARMACOLOGY, 176. doi:10.1016/j.bcp.2020.113893
McCallinhart, P. E., Biwer, L. A., Clark, O. E., Isakson, B. E., Lilly, B., & Trask, A. J. (2020). Myoendothelial Junctions of Mature Coronary Vessels Express Notch Signaling Proteins. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.00029
Ottolini, M., Hong, K., Cope, E. L., Daneva, Z., DeLalio, L. J., Sokolowski, J. D., . . . Sonkusare, S. K. (2020). Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. CIRCULATION, 141(16), 1318-1333. doi:10.1161/CIRCULATIONAHA.119.043385
Leo, F., Hutzler, B., Ruddiman, C. A., Isakson, B. E., & Cortese-Krott, M. M. (2020). Cellular microdomains for nitric oxide signaling in endothelium and red blood cells. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 96, 44-53. doi:10.1016/j.niox.2020.01.002
Kruger, N., Biwer, L. A., Good, M. E., Ruddiman, C. A., Wolpe, A. G., DeLalio, L. J., . . . Isakson, B. E. (2020). Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. CIRCULATION RESEARCH, 126(2), 232-242. doi:10.1161/CIRCRESAHA.119.315531
Good, M. E., Musante, L., La Salvia, S., Howell, N. L., Carey, R. M., Le, T. H., . . . Erdbruegger, U. (2020). Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries. HYPERTENSION, 75(1), 218-228. doi:10.1161/HYPERTENSIONAHA.119.13363
2019
Corliss, B. A., Delalio, L. J., Keller, T. C. S., Keller, A. S., Keller, D. A., Corliss, B. H., . . . Isakson, B. E. (2019). Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver. FRONTIERS IN PHYSIOLOGY, 10. doi:10.3389/fphys.2019.01389
Rival, C. M., Xu, W., Shankman, L. S., Morioka, S., Arandjelovic, S., Lee, C. S., . . . Ravichandran, K. S. (2019). Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-12406-z
Li, J., Cechova, S., Wang, L., Isakson, B. E., Le, T. H., & Shi, W. (2019). Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 316(6), F1141-F1150. doi:10.1152/ajprenal.00567.2018
Shu, X., Ruddiman, C. A., Keller, T. C. S., Keller, A. S., Yang, Y., Good, M. E., . . . Isakson, B. E. (2019). Heterocellular Contact Can Dictate Arterial Function. CIRCULATION RESEARCH, 124(10), 1473-1481. doi:10.1161/CIRCRESAHA.118.313926
DeLalio, L. J., Billaud, M., Ruddiman, C. A., Johnstone, S. R., Butcher, J. T., Wolpe, A. G., . . . Isakson, B. E. (2019). Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(17), 6940-6956. doi:10.1074/jbc.RA118.006982
Novielli-Kuntz, N. M., Jelen, M., Barr, K., DeLalio, L. J., Feng, Q., Isakson, B. E., . . . Laird, D. W. (2019). Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice. BIOSCIENCE REPORTS, 39. doi:10.1042/BSR20182350
2018
Artamonov, M. V., Sonkusare, S. K., Good, M. E., Momotani, K., Eto, M., Isakson, B. E., . . . Somlyo, A. V. (2018). RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger. SCIENCE SIGNALING, 11(554). doi:10.1126/scisignal.aar3924
Good, M. E., & Isakson, B. E. (2018). "Yin and Yang" for Notch signaling in the mature vasculature. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 315(6), H1789-H1790. doi:10.1152/ajpheart.00626.2018
Lechauve, C., Butcher, J. T., Freiwan, A., Biwer, L. A., Keith, J. M., Good, M. E., . . . Weiss, M. J. (2018). Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility. JOURNAL OF CLINICAL INVESTIGATION, 128(11), 5073-5082. doi:10.1172/JCI99933
Brown, I. A. M., Diederich, L., Good, M. E., DeLalio, L. J., Murphy, S. A., Cortese-Krott, M. M., . . . Isakson, B. E. (2018). Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(9), 1969-1985. doi:10.1161/ATVBAHA.118.311229
Suarez-Martinez, A. D., Peirce, S. M., Isakson, B. E., Nice, M., Wang, J., Lounsbury, K. M., . . . Murfee, W. L. (2018). Induction of microvascular network growth in the mouse mesentery. MICROCIRCULATION, 25(8). doi:10.1111/micc.12502
DeLalio, L. J., Keller, A. S., Chen, J., Boyce, A. K. J., Artamonov, M. V., Askew-Page, H. R., . . . Isakson, B. E. (2018). Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(9), 2065-2078. doi:10.1161/ATVBAHA.118.311290
Keller, A. S., Keller, T. C. S., DeLalio, L. J., Shahab, G., Yang, Y., Murphy, S. A., . . . Isakson, B. E. (2018). Replacement Therapies in Metabolic Disease. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 19(5), 382-399. doi:10.2174/1389201019666180619151413
Molica, F., Figueroa, X. F., Kwak, B. R., Isakson, B. E., & Gibbins, J. M. (2018). Connexins and Pannexins in Vascular Function and Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(6). doi:10.3390/ijms19061663
Jankowski, J., Perry, H. M., Medina, C. B., Huang, L., Yao, J., Bajwa, A., . . . Okusa, M. D. (2018). Epithelial and Endothelial Pannexin1 Channels Mediate AKI. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 29(7), 1887-1899. doi:10.1681/ASN.2017121306
Good, M. E., Chiu, Y. -H., Poon, I. K. H., Jaffe, I. Z., Bayliss, D. A., Isakson, B. E., & Ravichandran, K. S. (2018). Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone". CIRCULATION RESEARCH, 122(11), E88-E89. doi:10.1161/CIRCRESAHA.118.313080
Diederich, L., Suvorava, T., Sansone, R., Keller, T. C. S., Barbarino, F., Sutton, T. R., . . . Cortese-Krott, M. M. (2018). On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability. FRONTIERS IN PHYSIOLOGY, 9. doi:10.3389/fphys.2018.00332
Sharma, A. K., Charles, E. J., Zhao, Y., Narahari, A. K., Baderdinni, P. K., Good, M. E., . . . Laubach, V. E. (2018). Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 315(2), L301-L312. doi:10.1152/ajplung.00004.2018
Haskins, R. M., Nguyen, A. T., Alencar, G. F., Billaud, M., Kelly-Goss, M. R., Good, M. E., . . . Owens, G. K. (2018). Klf4 has an unexpected protective role in perivascular cells within the microvasculature. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 315(2), H402-H414. doi:10.1152/ajpheart.00084.2018
Johnstone, S. R., & Isakson, B. E. (2018). "Gaps' in targeted ischaemic injury therapies in ST-elevation myocardial infarction. HEART, 104(19), 1557-1558. doi:10.1136/heartjnl-2018-313084
Good, M. E., Eucker, S. A., Li, J., Bacon, H. M., Lang, S. M., Butcher, J. T., . . . Isakson, B. E. (2018). Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone. JCI INSIGHT, 3(6). doi:10.1172/jci.insight.96272
Hong, K., Cope, E. L., DeLalio, L. J., Marziano, C., Isakson, B. E., & Sonkusare, S. K. (2018). TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(3), 542-554. doi:10.1161/ATVBAHA.117.310038
Nyberg, M., Piil, P., Kiehn, O. T., Maagaard, C., Jorgensen, T. S., Egelund, J., . . . Hellsten, Y. (2018). Probenecid Inhibits -Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature. HYPERTENSION, 71(1), 151-159. doi:10.1161/HYPERTENSIONAHA.117.10251
Good, M. E., Chiu, Y. -H., Poon, I. K. H., Medina, C. B., Butcher, J. T., Mendu, S. K., . . . Ravichandran, K. S. (2018). Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. CIRCULATION RESEARCH, 122(4), 606-615. doi:10.1161/CIRCRESAHA.117.312380
Biwer, L. A., Good, M. E., Hong, K., Patel, R. K., Agrawal, N., Looft-Wilson, R., . . . Isakson, B. E. (2018). Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(1), 120-130. doi:10.1161/ATVBAHA.117.309886
Nyberg, M., Piil, P., Kiehn, O. T., Maagaard, C., Jørgensen, T. S., Egelund, J., . . . Hellsten, Y. (2018). Probenecid Inhibits α-Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature.. Hypertension (Dallas, Tex. : 1979), 71(1), 151-159. doi:10.1161/hypertensionaha.117.10251
2017
Isakson, B. (2017). A review of the current state of pannexin channels as they relate to the blood vessel wall. Journal of Medical Sciences, 37(5), 179. doi:10.4103/jmedsci.jmedsci_43_17
Marziano, C., Hong, K., Cope, E. L., Kotlikoff, M. I., Isakson, B. E., & Sonkusare, S. K. (2017). Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(12). doi:10.1161/JAHA.117.007157
Biwer, L. A., Lechauve, C., Vanhoose, S., Weiss, M. J., & Isakson, B. E. (2017). A Cell Culture Model of Resistance Arteries. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (127). doi:10.3791/55992
Keller, A. S., Diederich, L., Panknin, C., DeLalio, L. J., Drake, J. C., Sherman, R., . . . Isakson, B. E. (2017). Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 313(6), C593-C603. doi:10.1152/ajpcell.00178.2017
DeLalio, L. J., & Isakson, B. E. (2017). ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design. BRITISH JOURNAL OF PHARMACOLOGY, 174(15), 2606-2607. doi:10.1111/bph.13891
Keller, A. S., & Isakson, B. E. (2017). The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature. ANTIOXIDANTS & REDOX SIGNALING, 26(16), 881-885. doi:10.1089/ars.2017.7059
Durgin, B. G., Cherepanova, O. A., Gomez, D., Karaoli, T., Alencar, G. F., Butcher, J. T., . . . Connelly, J. J. (2017). Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 312(5), H943-H958. doi:10.1152/ajpheart.00029.2017
Begandt, D., Good, M. E., Keller, A. S., DeLalio, L. J., Rowley, C., Isakson, B. E., & Figueroa, X. F. (2017). Pannexin channel and connexin hemichannel expression in vascular function and inflammation. BMC CELL BIOLOGY, 18. doi:10.1186/s12860-016-0119-3
Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lueckstaedt, W., Panknin, C., . . . Cortese-Krott, M. M. (2017). Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia. ANTIOXIDANTS & REDOX SIGNALING, 26(13), 718-742. doi:10.1089/ars.2016.6954
Biwer, L. A., & Isakson, B. E. (2017). Endoplasmic reticulum-mediated signalling in cellular microdomains. ACTA PHYSIOLOGICA, 219(1), 162-175. doi:10.1111/apha.12675
2016
Shankman, L. S., Gomez, D., Cherepanova, O. A., Salmon, M., Alencar, G. F., Haskins, R. M., . . . Owens, G. K. (2016). Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.. Nature medicine, 22(2), 217. doi:10.1038/nm0216-217a
Shankman, L. S., Gomez, D., Cherepanova, O. A., Salmon, M., Alencar, G. F., Haskins, R. M., . . . Owens, G. K. (2016). KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis (vol 21, pg 628, 2015). NATURE MEDICINE, 22(2), 217. doi:10.1038/nm0216-217a
Keller, T. C. S., Butcher, J. T., Broseghini-Filho, G. B., Marziano, C., DeLalio, L. J., Rogers, S., . . . Isakson, B. E. (2016). Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbX). HYPERTENSION, 68(6), 1494-1503. doi:10.1161/HYPERTENSIONAHA.116.08171
Liu, S., DeLalio, L. J., Isakson, B. E., & Wang, T. T. (2016). AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus. CIRCULATION RESEARCH, 119(11), 1183-+. doi:10.1161/CIRCRESAHA.116.309866
Kauffenstein, G., Tamareille, S., Prunier, F., Roy, C., Ayer, A., Toutain, B., . . . Henrion, D. (2016). Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(8), 1598-1606. doi:10.1161/ATVBAHA.116.307739
Good, M. E., Begandt, D., DeLalio, L. J., Johnstone, S. R., & Isakson, B. E. (2016). Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells. GAP JUNCTION PROTOCOLS, 1437, 71-82. doi:10.1007/978-1-4939-3664-9_5
Biwer, L. A., Taddeo, E. P., Kenwood, B. M., Hoehn, K. L., Straub, A. C., & Isakson, B. E. (2016). Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861(7), 671-679. doi:10.1016/j.bbalip.2016.04.014
Ivanov, S., Scallan, J. P., Kim, K. -W., Werth, K., Johnson, M. W., Saunders, B. T., . . . Randolph, G. J. (2016). CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. JOURNAL OF CLINICAL INVESTIGATION, 126(4), 1581-1591. doi:10.1172/JCI84518
2015
Butcher, J., DeLalio, L., Biwer, L., Lang, S., Weaver, R., Best-Campbell, A., . . . Isakson, B. (2015). Endothelial Cell Hbα Can Regulate Blood Pressure. FASEB JOURNAL, 29.
Shu, X., Keller, T. C. S., Begandt, D., Butcher, J. T., Biwer, L., Keller, A. S., . . . Isakson, B. E. (2015). Endothelial nitric oxide synthase in the microcirculation. CELLULAR AND MOLECULAR LIFE SCIENCES, 72(23), 4561-4575. doi:10.1007/s00018-015-2021-0
Adamson, S. E., Meher, A. K., Chiu, Y. -H., Sandilos, J. K., Oberholtzer, N. P., Walker, N. N., . . . Leitinger, N. (2015). Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. MOLECULAR METABOLISM, 4(9), 610-618. doi:10.1016/j.molmet.2015.06.009
Chen, C. -H., Mayo, J. N., Gourdie, R. G., Johnstone, S. R., Isakson, B. E., & Bearden, S. E. (2015). The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 309(9), C600-C607. doi:10.1152/ajpcell.00155.2015
Lohman, A. W., Leskov, I. L., Butcher, J. T., Johnstone, S. R., Stokes, T. A., Begandt, D., . . . Isakson, B. E. (2015). Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms8965
Good, M. E., Begandt, D., DeLalio, L. J., Keller, A. S., Billaud, M., & Isakson, B. E. (2015). Emerging concepts regarding pannexin 1 in the vasculature. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 495-501. doi:10.1042/BST20150045
Shankman, L. S., Gomez, D., Cherepanova, O. A., Salmon, M., Alencar, G. F., Haskins, R. M., . . . Owens, G. K. (2015). KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. NATURE MEDICINE, 21(6), 628-637. doi:10.1038/nm.3866
Billaud, M., Chiu, Y. -H., Lohman, A. W., Parpaite, T., Butcher, J. T., Mutchler, S. M., . . . Isakson, B. E. (2015). A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. SCIENCE SIGNALING, 8(364). doi:10.1126/scisignal.2005824
Kavoussi, P. K., Heberlein, K., Straub, A. C., Lowe, G. J., Oliver, J. L., Smith, R. P., . . . Lysiak, J. J. (2015). Recombinant PAI-1 therapy restores myoendothelial junctions and erectile function in PAI-1-deficient mice. ANDROLOGIA, 47(10), 1147-1152. doi:10.1111/and.12395
2014
Butcher, J. T., DeLalio, L. J., Biwer, L. A., Weaver, R. B., & Isakson, B. E. (2014). Endothelial Hemoglobin Alpha by the HBA1 Gene Is Crucial to Release of NO-Derived Metabolites into Tissue and Blood. FREE RADICAL BIOLOGY AND MEDICINE, 76, S42. doi:10.1016/j.freeradbiomed.2014.10.390
Kauffenstein, G., Grimaud, L., Ayer, A., Toutain, B., Loufrani, L., Billaud, M., . . . Henrion, D. (2014). Signaling by extracellular nucleotides in resistance arteries-focus on myogenic tone. PURINERGIC SIGNALLING, 10(4), 798-799.
Isakson, B. E. (2014). Pannexin 1 channels on smooth muscle cell regulates α1-adrenergic vasoconstriction and blood pressure. PURINERGIC SIGNALLING, 10(4), 671.
Lohman, A., & Isakson, B. (2014). Pannexin 1-dependent ATP release from venous endothelium promotes acute vascular inflammation. FASEB JOURNAL, 28(1).
Biwer, L., Straub, A., & Isakson, B. (2014). Subcellular enrichment of calreticulin at myoendothelial junctions. FASEB JOURNAL, 28(1).
Straub, A., Anh, N., Mutchler, S., & Isakson, B. (2014). Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 42, 141. doi:10.1016/j.niox.2014.09.126
Straub, A. C., Zeigler, A. C., & Isakson, B. E. (2014). The Myoendothelial Junction: Connections That Deliver the Message. PHYSIOLOGY, 29(4), 242-249. doi:10.1152/physiol.00042.2013
Straub, A. C., Butcher, J. T., Billaud, M., Mutchler, S. M., Artamonov, M. V., Nguyen, A. T., . . . Isakson, B. E. (2014). Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(12), 2594-2600. doi:10.1161/ATVBAHA.114.303974
Adhikari, N., Billaud, M., Carlson, M., Lake, S. P., Montaniel, K. R. C., Staggs, R., . . . Hall, J. L. (2014). Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1. MOLECULAR AND CELLULAR BIOCHEMISTRY, 385(1-2), 225-238. doi:10.1007/s11010-013-1831-3
Isakson, B. E. (2014). Secreting von Willebrand factor in a Gα-SNAP. BLOOD, 123(3), 312-313. doi:10.1182/blood-2013-10-531913
Penuela, S., Lohman, A. W., Lai, W., Gyenis, L., Litchfield, D. W., Isakson, B. E., & Laird, D. W. (2014). Diverse post-translational modifications of the pannexin family of channel-forming proteins. CHANNELS, 8(2), 124-130. doi:10.4161/chan.27422
Lohman, A. W., & Isakson, B. E. (2014). Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS LETTERS, 588(8), 1379-1388. doi:10.1016/j.febslet.2014.02.004
Billaud, M., Lohman, A. W., Johnstone, S. R., Biwer, L. A., Mutchler, S., & Isakson, B. E. (2014). Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall. PHARMACOLOGICAL REVIEWS, 66(2), 513-569. doi:10.1124/pr.112.007351
Koval, M., Isakson, B. E., & Gourdie, R. G. (2014). Connexins, pannexins and innexins: Protein cousins with overlapping functions. FEBS LETTERS, 588(8), 1185. doi:10.1016/j.febslet.2014.03.001
Isakson, B. E., & Thompson, R. J. (2014). Pannexin-1 as a potentiator of ligand-gated receptor signaling. CHANNELS, 8(2), 118-123. doi:10.4161/chan.27978
Butcher, J. T., Johnson, T., Beers, J., Columbus, L., & Isakson, B. E. (2014). Hemoglobin α in the blood vessel wall. FREE RADICAL BIOLOGY AND MEDICINE, 73, 136-142. doi:10.1016/j.freeradbiomed.2014.04.019
2013
Isakson, B. (2013). REGULATION OF NO BY HEMOGLOBIN IN THE ENDOTHELIUM. FREE RADICAL BIOLOGY AND MEDICINE, 65, S8. doi:10.1016/j.freeradbiomed.2013.10.404
Cechova, S., Zeng, Q., Billaud, M., Mutchler, S., Rudy, C. K., Straub, A. C., . . . Le, T. H. (2013). Loss of Collectrin, an Angiotensin-Converting Enzyme 2 Homolog, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction. CIRCULATION, 128(16), 1770-1780. doi:10.1161/CIRCULATIONAHA.113.003301
2012
Kauffenstein, G., Ayer, A., Toutain, B., Grimaud, L., Billaud, M., Isakson, B., . . . Henrion, D. (2012). 767 SIGNALING BY EXTRACELLULAR NUCLEOTIDES IN THE VASCULATURE â FOCUS ON MYOGENIC TONE. Journal of Hypertension, 30(Supplement 1), e221. doi:10.1097/01.hjh.0000420734.45312.8b
Straub, A., Dwyer, S., Gaston, B., & Isakson, B. (2012). Endothelial cell expression of hemoglobin a regulates nitric oxide signaling. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 27, S13. doi:10.1016/j.niox.2012.04.048
Montaniel, K. R. C., Adhikari, N., Lake, S., Billaud, M., Carlson, M., Isakson, B. E., . . . Hall, J. L. (2012). Smooth Muscle Specific Deletion of N-deacetylase-sulfotransferase1 (Ndst1) Results in Altered Arterial Elasticity. CIRCULATION, 126(21).
Billaud, M., Lohman, A. W., Chiu, Y. -H., Sandilos, J. K., Bayliss, D. A., & Isakson, B. E. (2012). Exclusive interaction between α1D-adrenergic receptor and pannexin 1 can mediate vasoconstriction. FASEB JOURNAL, 26.
Lohman, A. W., Weaver, J. L., Billaud, M., Bayliss, D. A., & Isakson, B. E. (2012). Complex interplay between Pannexin 1 cysteine residues and channel regulation. FASEB JOURNAL, 26.
Straub, A., Lohman, A., Billaud, M., Dwyer, S., Best, A., Gaston, B., & Isakson, B. (2012). Cytochrome B 5 reductase 3 regulates nitric oxide signaling at the myoendothelial by controlling hemoglobin redox cycling. FASEB JOURNAL, 26.
Johnstone, S. R., Kroncke, B. M., Straub, A. C., Best, A. K., Dunn, C. A., Koval, M., . . . Isakson, B. E. (2012). MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. FASEB JOURNAL, 26.
Straub, A., Lohman, A., Billaud, M., Johnstone, S., Dwyer, S., Lee, M., . . . Isakson, B. (2012). Hemoglobin expression at the myoendothelial junction regulates nitric oxide scavenging and vasomotor tone. FASEB JOURNAL, 26.
Lohman, A. W., Billaud, M., Straub, A. C., Best, A. K., Lee, M., Barr, K., . . . Isakson, B. E. (2012). Expression of pannexin isoforms in the murine arterial network. FASEB JOURNAL, 26.
Lowe, G., Kavoussi, P., Straub, A., Steers, W., Costabile, R., Isakson, B., & Lysiak, J. (2012). MYOENDOTHELIAL JUNCTIONS IN THE CORPUS CAVERNOSUM ARE LOST AFTER CAVERNOUS NERVE INJURY. JOURNAL OF SEXUAL MEDICINE, 9, 11.
Billaud, M., Lohman, A. W., Straub, A. C., Parpaite, T., Johnstone, S. R., & Isakson, B. E. (2012). Characterization of the Thoracodorsal Artery: Morphology and Reactivity. MICROCIRCULATION, 19(4), 360-372. doi:10.1111/j.1549-8719.2012.00172.x
Looft-Wilson, R. C., Billaud, M., Johnstone, S. R., Straub, A. C., & Isakson, B. E. (2012). Interaction between nitric oxide signaling and gap junctions: Effects on vascular function. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1818(8), 1895-1902. doi:10.1016/j.bbamem.2011.07.031
Billaud, M., Johnstone, S. R., & Isakson, B. E. (2012). Loss of Compliance in Small Arteries, but Not in Conduit Arteries, After 6 Weeks Exposure to High Fat Diet. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 5(3), 256-263. doi:10.1007/s12265-012-9354-y
Heberlein, K. R., Han, J., Straub, A. C., Best, A. K., Kaun, C., Wojta, J., & Isakson, B. E. (2012). A Novel mRNA Binding Protein Complex Promotes Localized Plasminogen Activator Inhibitor-1 Accumulation at the Myoendothelial Junction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(5), 1271-+. doi:10.1161/ATVBAHA.112.246371
Johnstone, S. R., Kroncke, B. M., Straub, A. C., Best, A. K., Dunn, C. A., Mitchell, L. A., . . . Isakson, B. E. (2012). MAPK Phosphorylation of Connexin 43 Promotes Binding of Cyclin E and Smooth Muscle Cell Proliferation. CIRCULATION RESEARCH, 111(2), 201-U205. doi:10.1161/CIRCRESAHA.112.272302
Montaniel, K. R. C., Billaud, M., Graham, C., Kim, S. K., Carlson, M., Zeng, W., . . . Adhikari, N. (2012). Smooth Muscle Specific Deletion of Ndst1 Leads to Decreased Vessel Luminal Area and No Change in Blood Pressure in Conscious Mice. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 5(3), 274-279. doi:10.1007/s12265-012-9369-4
Lohman, A. W., Billaud, M., Straub, A. C., Johnstone, S. R., Best, A. K., Lee, M., . . . Isakson, B. E. (2012). Expression of Pannexin Isoforms in the Systemic Murine Arterial Network. JOURNAL OF VASCULAR RESEARCH, 49(5), 405-416. doi:10.1159/000338758
Lohman, A. W., Billaud, M., & Isakson, B. E. (2012). Mechanisms of ATP release and signalling in the blood vessel wall. CARDIOVASCULAR RESEARCH, 95(3), 269-280. doi:10.1093/cvr/cvs187
Billaud, M., Sandilos, J. K., & Isakson, B. E. (2012). Pannexin 1 in the Regulation of Vascular Tone. TRENDS IN CARDIOVASCULAR MEDICINE, 22(3), 68-72. doi:10.1016/j.tcm.2012.06.014
Johnstone, S. R., Billaud, M., Lohman, A. W., Taddeo, E. P., & Isakson, B. E. (2012). Posttranslational Modifications in Connexins and Pannexins. JOURNAL OF MEMBRANE BIOLOGY, 245(5-6), 319-332. doi:10.1007/s00232-012-9453-3
Wang, L., Yin, J., Nickles, H. T., Ranke, H., Tabuchi, A., Hoffmann, J., . . . Kuebler, W. M. (2012). Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. JOURNAL OF CLINICAL INVESTIGATION, 122(11), 4218-4230. doi:10.1172/JCI59176
Lohman, A. W., Weaver, J. L., Billaud, M., Sandilos, J. K., Griffiths, R., Straub, A. C., . . . Isakson, B. E. (2012). S-Nitrosylation Inhibits Pannexin 1 Channel Function. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(47). doi:10.1074/jbc.M112.397976
Straub, A. C., Lohman, A. W., Billaud, M., Johnstone, S. R., Dwyer, S. T., Lee, M. Y., . . . Isakson, B. E. (2012). Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. NATURE, 491(7424), 473-477. doi:10.1038/nature11626
2011
Sandilos, J. K., Chekeni, F. B., Elliott, M. R., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., . . . Bayliss, D. A. (2011). Caspases Mediate Pannexin 1 Channel Activation in Apoptotic Cells. Biophysical Journal, 100(3), 101a. doi:10.1016/j.bpj.2010.12.759
Straub, A. C., Billaud, M., Best, A. K., & Isakson, B. E. (2011). Apical and basal endothelial nitric oxide release each regulate distinct subcellular functions within the vessel wall. FASEB JOURNAL, 25.
Isakson, B. E., Billaud, M., Lohman, A. W., Straub, A. C., Sandilos, J. K., & Bayliss, D. A. (2011). S-nitrosylation of pannexin 1 reduces channel permeability, potentially regulating vasoconstriction. JOURNAL OF VASCULAR RESEARCH, 48, 8.
Heberlein, K., Straub, A. C., Best, A. K., Wojta, J., & Isakson, B. E. (2011). Nicotinamide phosphoribosyl transferase coordinates stabilization of plasminogen activator inhibitor-1 mRNA at the myoendothelial junction. FASEB JOURNAL, 25.
Billaud, M., Lohman, A. W., Sandilos, J. K., Bayliss, D. A., & Isakson, B. E. (2011). Exclusive interaction between α1D-adrenergic receptor and pannexin 1 can mediate vasoconstriction. JOURNAL OF VASCULAR RESEARCH, 48, 118.
Straub, A., Billaud, M., Johnstone, S. R., Best, A. K., Looft-Wilson, R., Gaston, B., . . . Isakson, B. E. (2011). Compartmentalized redox signaling at the myoendothelial junction regulates heterocellular communication in the vessel wall. FASEB JOURNAL, 25.
Isakson, B. E., & Billaud, M. (2011). Expression and function of pannexins in the vasculature. JOURNAL OF VASCULAR RESEARCH, 48, 6.
Cechova, S., Zeng, Q., Billaud, M., Straub, A., Isakson, B., & Thu, L. (2011). Deletion Of Collectrin, An Ace-2 Homologue, Results In Altered eNOS Expression And Impaired Endothelium-dependent Vasorelaxation. HYPERTENSION, 58(5), E150.
Straub, A. C., Billaud, M., Johnstone, S. R., Best, A. K., Yemen, S., Dwyer, S. T., . . . Isakson, B. E. (2011). Compartmentalized Connexin 43 S-Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(2), 399-U353. doi:10.1161/ATVBAHA.110.215939
Billaud, M., Lohman, A. W., Straub, A. C., Looft-Wilson, R., Johnstone, S. R., Araj, C. A., . . . Isakson, B. E. (2011). Pannexin1 Regulates α1-Adrenergic Receptor-Mediated Vasoconstriction. CIRCULATION RESEARCH, 109(1), 80-U284. doi:10.1161/CIRCRESAHA.110.237594
Billaud, M., Ross, J. A., Greyson, M. A., Bruce, A. C., Seaman, S. A., Heberlein, K. R., . . . Isakson, B. E. (2011). A New Method for In Vivo Visualization of Vessel Remodeling Using a Near-Infrared Dye. MICROCIRCULATION, 18(3), 163-171. doi:10.1111/j.1549-8719.2011.00085.x
Koval, M., Billaud, M., Straub, A. C., Johnstone, S. R., Zarbock, A., Duling, B. R., & Isakson, B. E. (2011). Spontaneous Lung Dysfunction and Fibrosis in Mice Lacking Connexin 40 and Endothelial Cell Connexin 43. AMERICAN JOURNAL OF PATHOLOGY, 178(6), 2536-2546. doi:10.1016/j.ajpath.2011.02.045
2010
Heberlein, K. R., Straub, A. C., Best, A. K., Greyson, M. A., Looft-Wilson, R. C., Sharma, P. R., . . . Isakson, B. E. (2010). Plasminogen Activator Inhibitor-1 Regulates Myoendothelial Junction Formation. CIRCULATION RESEARCH, 106(6), 1092-1102. doi:10.1161/CIRCRESAHA.109.215723
Wang, L., Yin, J., Isakson, B., de Wit, C., & Kuebler, W. M. (2010). A critical role for connexin 40 in hypoxia induced pulmonary vasoconstriction. FASEB JOURNAL, 24.
Straub, A. C., Johnstone, S. R., Best, A. K., Palmer, L., & Isakson, B. E. (2010). Compartmentalized nitric oxide signaling at the myoendothelial junction can regulate gap junction communication. FASEB JOURNAL, 24.
Heberlein, K., Han, J., Zorn, G., Kaun, C., Straub, A. C., Best, A. K., . . . Isakson, B. E. (2010). The potential for localized translation and induction of plasminogen activator inhibitor-1 at the myoendothelial junction in response to TNF-alpha. FASEB JOURNAL, 24.
Chen, C. -H., Beard, R. S., Straub, A. C., Heberlein, K., Isakson, B. E., & Bearden, S. E. (2010). Homocysteine Modulates the Density and Composition of Myoendothelial Junctions. CIRCULATION, 122(21).
Merrick, E. C., Kalmar, C. L., Snyder, S. L., Cusdin, F. S., Yu, E. J., Sando, J. J., . . . Patel, M. K. (2010). The importance of serine 161 in the sodium channel β3 subunit for modulation of NaV1.2 gating. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 460(4), 743-753. doi:10.1007/s00424-009-0739-y
Straub, A. C., Johnstone, S. R., Heberlein, K. R., Rizzo, M. J., Best, A. K., Boitano, S., & Isakson, B. E. (2010). Site-Specific Connexin Phosphorylation Is Associated with Reduced Heterocellular Communication between Smooth Muscle and Endothelium. JOURNAL OF VASCULAR RESEARCH, 47(4), 277-286. doi:10.1159/000265562
Kadl, A., Meher, A. K., Sharma, P. R., Lee, M. Y., Doran, A. C., Johnstone, S. R., . . . Leitinger, N. (2010). Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2. CIRCULATION RESEARCH, 107(6), 737-U155. doi:10.1161/CIRCRESAHA.109.215715
Johnstone, S. R., Best, A. K., Wright, C. S., Isakson, B. E., Errington, R. J., & Martin, P. E. (2010). Enhanced Connexin 43 Expression Delays Intra-Mitoitc Duration and Cell Cycle Traverse Independently of Gap Junction Channel Function. JOURNAL OF CELLULAR BIOCHEMISTRY, 110(3), 772-782. doi:10.1002/jcb.22590
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., . . . Ravichandran, K. S. (2010). Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. NATURE, 467(7317), 863-U136. doi:10.1038/nature09413