Jie Yang
- Website: https://jieyang-lab.com/
Primary Appointment
Assistant Professor, Biochemistry and Molecular Genetics
Education
- BS, Biological Sciences, Wuhan University, China
- PhD, Biophysics, Case Western Reserve University. Cleveland, Ohio
- Postdoc, Structural Biology, Scripps Research. La Jolla, CA
Research Disciplines
Biochemistry, Biophysics, Cell and Developmental Biology, Molecular Biology, Structural Biology
Research Interests
Structural mechanisms of macromolecular complexes, Cryo-EM, Mitochondrial stress, Endoplasmic reticulum stress, Cellular stress response
Selected Publications
2023
Yang, J., Baron, K. R., Pride, D. E., Schneemann, A., Guo, X., Chen, W., . . . Lander, G. C. (2023). DELE1 oligomerization promotes integrated stress response activation. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 30(9), 1295-+. doi:10.1038/s41594-023-01061-0
2022
Li, Y., Liu, Z., Zhao, Y., Yang, J., Xiao, T. S., Conlon, R. A., & Wang, Z. (2023). PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain. GENES & DISEASES, 10(4), 1702-1713. doi:10.1016/j.gendis.2022.11.003
Yang, J., Song, A. S., Wiseman, R. L. C., & Lander, G. (2022). Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. JOURNAL OF BIOLOGICAL CHEMISTRY, 298(3). doi:10.1016/j.jbc.2022.101694
2020
Liu, Z., Wang, C., Yang, J., Chen, Y., Zhou, B., Abbott, D. W., & Xiao, T. S. (2020). Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. IMMUNITY, 53(1), 106-+. doi:10.1016/j.immuni.2020.06.007
2019
Liu, Z., Wang, C., Yang, J., Zhou, B., Yang, R., Ramachandran, R., . . . Xiao, T. S. (2019). Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. IMMUNITY, 51(1), 43-+. doi:10.1016/j.immuni.2019.04.017
2018
Rathkey, J. K., Zhao, J., Liu, Z., Chen, Y., Yang, J., Kondolf, H. C., . . . Abbott, D. W. (2018). Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. SCIENCE IMMUNOLOGY, 3(26). doi:10.1126/sciimmunol.aat2738
Yang, J., Liu, Z., Wang, C., Yang, R., Rathkey, J. K., Pinkard, O. W., . . . Xiao, T. S. (2018). Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(26), 6792-6797. doi:10.1073/pnas.1800562115
Liu, Z., Wang, C., Rathkey, J. K., Yang, J., Dubyak, G. R., Abbott, D. W., & Xiao, T. S. (2018). Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. STRUCTURE, 26(5), 778-+. doi:10.1016/j.str.2018.03.002
2017
Rathkey, J. K., Benson, B. L., Chirieleison, S. M., Yang, J., Xiao, T. S., Dubyak, G. R., . . . Abbott, D. W. (2017). Live-cell visualization of gasdermin D-driven pyroptotic cell death. JOURNAL OF BIOLOGICAL CHEMISTRY, 292(35), 14649-14658. doi:10.1074/jbc.M117.797217
2016
Yang, J., Liu, Z., & Xiao, T. S. (2017). Post-translational regulation of inflammasomes. CELLULAR & MOLECULAR IMMUNOLOGY, 14(1), 65-79. doi:10.1038/cmi.2016.29