Muge N Kuyumcu-Martinez
- Email: pnc3uj@virginia.edu
Primary Appointment
Professor, Molecular Physiology and Biological Physics
Research Disciplines
Molecular Physiology and Biological Physics
Research Interests
RNA regulatory networks and RNA binding proteins during cardiovascular development and in cardiovascular disease
Selected Publications
2024
Verma, S. K., & Kuyumcu-Martinez, M. N. (2024). RNA binding proteins in cardiovascular development and disease.. Current topics in developmental biology, 156, 51-119. doi:10.1016/bs.ctdb.2024.01.007
2023
Deberneh, H. M., Abdelrahman, D. R., Verma, S. K., Linares, J. J., Murton, A. J., Russell, W. K., . . . Sadygov, R. G. (2023). Quantifying label enrichment from two mass isotopomers increases proteome coverage for in vivo protein turnover using heavy water metabolic labeling. COMMUNICATIONS CHEMISTRY, 6(1). doi:10.1038/s42004-023-00873-x
Deberneh, H. M., Abdelrahman, D. R., Verma, S. K., Linares, J. J., Murton, A. J., Russell, W. K., . . . Sadygov, R. G. (2023). A large-scale LC-MS dataset of murine liver proteome from time course of heavy water metabolic labeling. SCIENTIFIC DATA, 10(1). doi:10.1038/s41597-023-02537-w
Mehlferber, M. M., Kuyumcu-Martinez, M., Miller, C. L., & Sheynkman, G. M. (2023). Transcription Factors and Splice Factors-Interconnected Regulators of Stem Cell Differentiation. CURRENT STEM CELL REPORTS, 9(2), 31-41. doi:10.1007/s40778-023-00227-2
Cao, J., & Kuyumcu-Martinez, M. N. (2023). Alternative polyadenylation regulation in cardiac development and cardiovascular disease. CARDIOVASCULAR RESEARCH, 119(6), 1324-1335. doi:10.1093/cvr/cvad014
2022
Sotcheff, S. L., Chen, J. Y. -C., Elrod, N., Cao, J., Jaworski, E., Kuyumcu-Martinez, M. N., . . . Routh, A. L. (2022). Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells. PATHOGENS, 11(8). doi:10.3390/pathogens11080936
Verma, S. K., Deshmukh, V., Thatcher, K., Belanger, K. K., Rhyner, A. M., Meng, S., . . . Kuyumcu-Martinez, M. N. (2022). RBFOX2 is required for establishing RNA regulatory networks essential for heart development. NUCLEIC ACIDS RESEARCH, 50(4), 2270-2286. doi:10.1093/nar/gkac055
Cooper, A. M., Nutter, C. A., Kuyumcu-Martinez, M. N., & Wright, C. W. (2022). Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies. MOLECULAR AND CELLULAR BIOLOGY, 42(5). doi:10.1128/mcb.00503-21
2021
Cao, J., Routh, A. L., & Kuyumcu-Martinez, M. N. (2021). Nanopore sequencing reveals full-length Tropomyosin 1 isoforms and their regulation by RNA-binding proteins during rat heart development. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 25(17), 8352-8362. doi:10.1111/jcmm.16795
Cao, J., Verma, S. K., Jaworski, E., Mohan, S., Nagasawa, C. K., Rayavara, K., . . . Kuyumcu-Martinez, M. N. (2021). RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts. CELL REPORTS, 37(5). doi:10.1016/j.celrep.2021.109910
2020
Wan, X., Belanger, K., Widen, S. G., Kuyumcu-Martinez, M. N., & Garg, N. J. (2020). Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2.. Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165620. doi:10.1016/j.bbadis.2019.165620
2018
Belanger, K., Nutter, C. A., Li, J., Yu, P., & Kuyumcu-Martinez, M. N. (2019). A developmentally regulated spliced variant of PTBP1 is upregulated in type 1 diabetic hearts. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 509(2), 384-389. doi:10.1016/j.bbrc.2018.12.150
Nutter, C. A., & KuyumcuâMartinez, M. N. (2018). Cover Image, Volume 9, Issue 2. WIREs RNA, 9(2). doi:10.1002/wrna.1472
Belanger, K., Nutter, C. A., Li, J., Tasnim, S., Liu, P., Yu, P., & Kuyumcu-Martinez, M. N. (2018). CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 503(4), 3205-3211. doi:10.1016/j.bbrc.2018.08.126
2017
Nutter, C. A., & Kuyumcu-Martinez, M. N. (2018). Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications. WILEY INTERDISCIPLINARY REVIEWS-RNA, 9(2). doi:10.1002/wrna.1459
Nutter, C. A., Jaworski, E., Verma, S. K., Perez-Carrasco, Y., & Kuyumcu-Martinez, M. N. (2017). DEVELOPMENTALLY REGULATED ALTERNATIVE SPLICING IS PERTURBED IN TYPE 1 DIABETIC SKELETAL MUSCLE. MUSCLE & NERVE, 56(4), 744-749. doi:10.1002/mus.25599
2016
Chattopadhyay, A., Pinkaew, D., Doan, H. Q., Jacob, R. B., Verma, S. K., Friedman, H., . . . Fujise, K. (2016). Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. SCIENTIFIC REPORTS, 6. doi:10.1038/srep18701
Nutter, C. A., Jaworski, E. A., Verma, S. K., Deshmukh, V., Wang, Q., Botvinnik, O. B., . . . Kuyumcu-Martinez, M. N. (2016). Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. CELL REPORTS, 15(10), 2200-2213. doi:10.1016/j.celrep.2016.05.002
Verma, S. K., Deshmukh, V., Nutter, C. A., Jaworski, E., Jin, W., Wadhwa, L., . . . Kuyumcu-Martinez, M. N. (2016). Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts. SCIENTIFIC REPORTS, 6. doi:10.1038/srep30896
Koo, S. -J., Spratt, H. M., Soman, K. V., Stafford, S., Gupta, S., Petersen, J. R., . . . Garg, N. J. (2016). S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure.. International journal of proteomics, 2016, 1384523. doi:10.1155/2016/1384523
Kuyumcu-Martinez, M. N., & Bressan, M. C. (2016). Rebuilding a broken heart: lessons from developmental and regenerative biology. DEVELOPMENT, 143(21), 3866-3870. doi:10.1242/dev.143842
2013
Verma, S. K., Deshmukh, V., Liu, P., Nutter, C. A., Espejo, R., Hung, M. -L., . . . Kuyumcu-Martinez, M. N. (2013). Reactivation of Fetal Splicing Programs in Diabetic Hearts Is Mediated by Protein Kinase C Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(49), 35372-35386. doi:10.1074/jbc.M113.507426