Horitani, K., Chavkin, N. W., Arai, Y., Wang, Y., Ogawa, H., Yura, Y., . . . Walsh, K. (2024). Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure. NATURE CARDIOVASCULAR RESEARCH, 3(3). doi:10.1038/s44161-024-00441-z

Genet, G., Genet, N., Paila, U., Cain, S. R., Cwiek, A., Chavkin, N. W., . . . Hirschi, K. K. (2024). Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. CIRCULATION, 149(12), 944-962. doi:10.1161/CIRCULATIONAHA.122.062952

Dunaway, L. S., Luse, M. A., Nyshadham, S., Bulut, G., Alencar, G. F., Chavkin, N. W., . . . Isakson, B. E. (2024). Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium.. Physiological genomics, 56(2), 113-127. doi:10.1152/physiolgenomics.00109.2023

Wilcox, N. S., Yarovinsky, T. O., Pandya, P., Ramgolam, V. S., Moro, A., Wu, Y., . . . Bender, J. R. (2023). Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. ISCIENCE, 26(12). doi:10.1016/j.isci.2023.107985

Cochran, J. D., Yura, Y., Thel, M. C., Doviak, H., Polizio, A. H., Arai, Y., . . . Walsh, K. (2023). Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction. CIRCULATION, 148(15), 1165-1178. doi:10.1161/CIRCULATIONAHA.123.064170

Wu, Y., Paila, U., Genet, G., & Hirschi, K. K. (2023). MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis. DEVELOPMENTAL CELL, 58(14), 1237-+. doi:10.1016/j.devcel.2023.05.007

Acharya, B. R., Fang, J. S., Jeffery, E., Chavkin, N. W., Genet, G., Vasavada, H., . . . Hirschi, K. K. (2023). Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. LIFE SCIENCE ALLIANCE, 6(8). doi:10.26508/lsa.202201685

Kam, C. Y., Singh, I. D., Gonzalez, D. G., Matte-Martone, C., Sola, P., Solanas, G., . . . Greco, V. (2023). Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. CELL, 186(11), 2345-+. doi:10.1016/j.cell.2023.04.017

Leiby, K. L., Yuan, Y., Ng, R., Raredon, M. S. B., Adams, T. S., Baevova, P., . . . Niklason, L. E. (2023). Rational engineering of lung alveolar epithelium. NPJ REGENERATIVE MEDICINE, 8(1). doi:10.1038/s41536-023-00295-2

Genet, N., Genet, G., Chavkin, N. W., Paila, U., Fang, J. S., Vasavada, H. H., . . . Hirschi, K. K. (2023). Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. CELL REPORTS, 42(4). doi:10.1016/j.celrep.2023.112371

de Souza, V. B. C., Jordan, B. T. T., Tseng, E., Nelson, E. A. A., Hirschi, K. K. K., Sheynkman, G., & Robinson, M. D. D. (2023). Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data. GENOME BIOLOGY, 24(1). doi:10.1186/s13059-023-02923-y

Chavkin, N. W., Vippa, T., Jung, C., McDonnell, S., Hirschi, K. K., Gokce, N., & Walsh, K. (2023). Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans. FRONTIERS IN CARDIOVASCULAR MEDICINE, 10. doi:10.3389/fcvm.2023.1264479

Chavkin, N. W., Genet, G., Poulet, M., Jeffery, E. D., Marziano, C., Genet, N., . . . Hirschi, K. K. (2022). Endothelial cell cycle state determines propensity for arterial-venous fate. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-33324-7

Aragon, J. W. W., & Hirschi, K. K. K. (2022). Endothelial Cell Differentiation and Hemogenic Specification. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 12(7). doi:10.1101/cshperspect.a041164

Sano, S., Horitani, K., Ogawa, H., Halvardson, J., Chavkin, N. W., Wang, Y., . . . Walsh, K. (2022). Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. SCIENCE, 377(6603), 292-297. doi:10.1126/science.abn3100

Ronaldson-Bouchard, K., Teles, D., Yeager, K., Tavakol, D. N., Zhao, Y., Chramiec, A., . . . Vunjak-Novakovic, G. (2022). A multi-organ chip with matured tissue niches linked by vascular flow. NATURE BIOMEDICAL ENGINEERING, 6(4), 351-+. doi:10.1038/s41551-022-00882-6

Hong, L., Li, N., Gasque, V., Mehta, S., Ye, L., Wu, Y., . . . Mani, A. (2022). Prdm6 controls heart development by regulating neural crest cell differentiation and. JCI INSIGHT, 7(4). doi:10.1172/jci.insight.156046

Mehlferber, M. M., Jeffery, E. D., Saquing, J., Jordan, B. T., Sheynkman, L., Murali, M., . . . Sheynkman, G. M. (2022). Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics. RNA BIOLOGY, 19(1), 1228-1243. doi:10.1080/15476286.2022.2141938

Chavkin, N. W., Cain, S., Walsh, K., & Hirschi, K. K. (2021). Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (176). doi:10.3791/63133

Genet, N., & Hirschi, K. K. (2021). Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. REGENERATIVE MEDICINE, 16(09), 861-870. doi:10.2217/rme-2021-0022

Chavkin, N. W., Sano, S., Wang, Y., Oshima, K., Ogawa, H., Horitani, K., . . . Walsh, K. (2021). The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(13). doi:10.1161/JAHA.120.019904

Marziano, C., Genet, G., & Hirschi, K. K. (2021). Vascular endothelial cell specification in health and disease. ANGIOGENESIS, 24(2), 213-236. doi:10.1007/s10456-021-09785-7

Nelson, E. A., Qiu, J., Chavkin, N. W., & Hirschi, K. K. (2021). Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (169). doi:10.3791/62391

Tavakol, D. N., Chen, J., Chavkin, N. W., Tavakol, T. N., Hirschi, K. K., & Vunjak-Novakovic, G. (2021). Lessons from Biology: Engineering Design Considerations for Modeling Human Hematopoiesis. CURRENT STEM CELL REPORTS, 7(4), 174-184. doi:10.1007/s40778-021-00195-5

Kasper, D. M., Hintzen, J., Wu, Y., Ghersi, J. J., Mandl, H. K., Salinas, K. E., . . . Nicoli, S. (2020). The N-glycome regulates the endothelial-to-hematopoietic transition. SCIENCE, 370(6521), 1186-+. doi:10.1126/science.aaz2121

Qiu, J., Nordling, S., Vasavada, H. H., Butcher, E. C., & Hirschi, K. K. (2020). Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. CELL REPORTS, 33(9). doi:10.1016/j.celrep.2020.108465

Wu, Y., & Hirschi, K. K. (2021). Regulation of Hemogenic Endothelial Cell Development and Function. ANNUAL REVIEW OF PHYSIOLOGY, VOL 83, 83, 17-37. doi:10.1146/annurev-physiol-021119-034352

Chavkin, N. W., Walsh, K., & Hirschi, K. K. (2021). Isolation of Highly Purified and Viable Retinal Endothelial Cells. JOURNAL OF VASCULAR RESEARCH, 58(1), 49-57. doi:10.1159/000510533

Wang, Y., Sano, S., Yura, Y., Ke, Z., Sano, M., Oshima, K., . . . Walsh, K. (2020). Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. JCI INSIGHT, 5(6). doi:10.1172/jci.insight.135204

Matta, R., Lee, S., Genet, N., Hirschi, K. K., Thomas, J. -L., & Gonzalez, A. L. (2020). Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone (vol 9, 17798, 2019). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-57577-8

Wu, Y., & Hirschi, K. K. (2021). Tissue-Resident Macrophage Development and Function. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8. doi:10.3389/fcell.2020.617879

Chavkin, N. W., & Hirschi, K. K. (2020). Single Cell Analysis in Vascular Biology. FRONTIERS IN CARDIOVASCULAR MEDICINE, 7. doi:10.3389/fcvm.2020.00042

Matta, R., Lee, S., Genet, N., Hirschi, K. K., Thomas, J. -L., & Gonzalez, A. L. (2019). Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-54167-1

Qiu, J., & Hirschi, K. K. (2019). Endothelial Cell Development and Its Application to Regenerative Medicine. CIRCULATION RESEARCH, 125(4), 489-501. doi:10.1161/CIRCRESAHA.119.311405

Fang, J., & Hirschi, K. (2019). Molecular regulation of arteriovenous endothelial cell specification.. F1000Research, 8, F1000 Faculty Rev-1208. doi:10.12688/f1000research.16701.1

Hirschi, K. K., & Dejana, E. (2018). Resident Endothelial Progenitors Make Themselves at Home. CELL STEM CELL, 23(2), 153-155. doi:10.1016/j.stem.2018.07.014

Fang, J. S., Coon, B. G., Gillis, N., Chen, Z., Qiu, J., Chittenden, T. W., . . . Hirschi, K. K. (2018). Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification (vol 8, 2017). NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-03076-4

Genet, N., Bhatt, N., Bourdieu, A., & Hirschi, K. K. (2018). Multifaceted Roles of Connexin 43 in Stem Cell Niches. CURRENT STEM CELL REPORTS, 4(1), 1-12. doi:10.1007/s40778-018-0110-3

Fang, J. S., Coon, B. G., Gillis, N., Chen, Z., Qiu, J., Chittenden, T. W., . . . Hirschi, K. K. (2017). Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. NATURE COMMUNICATIONS, 8. doi:10.1038/s41467-017-01742-7

Polacheck, W. J., Kutys, M. L., Yang, J., Eyckmans, J., Wu, Y., Vasavada, H., . . . Chen, C. S. (2017). A non-canonical Notch complex regulates adherens junctions and vascular barrier function. NATURE, 552(7684), 258-+. doi:10.1038/nature24998

Sivarapatna, A., Ghaedi, M., Xiao, Y., Han, E., Aryal, B., Zhou, J., . . . Niklason, L. E. (2017). Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. CELL TRANSPLANTATION, 26(8), 1365-1379. doi:10.1177/0963689717720282

Yu, P., Wilhelm, K., Dubrac, A., Tung, J. K., Alves, T. C., Fang, J. S., . . . Simons, M. (2017). FGF-dependent metabolic control of vascular development. NATURE, 545(7653), 224-+. doi:10.1038/nature22322

Hirschi, K. K., Nicoli, S., & Walsh, K. (2017). Hematopoiesis Lineage Tree Uprooted: Every HSPC Is a Rainbow. DEVELOPMENTAL CELL, 41(1), 7-9. doi:10.1016/j.devcel.2017.03.020

Dejana, E., Hirschi, K. K., & Simons, M. (2017). The molecular basis of endothelial cell plasticity. NATURE COMMUNICATIONS, 8. doi:10.1038/ncomms14361

Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., . . . Walsh, K. (2017). Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. SCIENCE, 355(6327), 842-847. doi:10.1126/science.aag1381

Ola, R., Dubrac, A., Han, J., Zhang, F., Fang, J. S., Larrivee, B., . . . Eichmann, A. (2016). PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms13650

Ceneri, N., Zhao, L., Young, B. D., Healy, A., Coskun, S., Vasavada, H., . . . Morrison, A. R. (2017). Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37(2), 328-+. doi:10.1161/ATVBAHA.116.308507

Wang, Y., Baeyens, N., Corti, F., Tanaka, K., Fang, J. S., Zhang, J., . . . Simons, M. (2016). Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. DEVELOPMENT, 143(23), 4441-4451. doi:10.1242/dev.140129

Fang, J. S., Gritz, E. C., Marcelo, K. L., & Hirschi, K. K. (2016). Isolation of Murine Embryonic Hemogenic Endothelial Cells. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (112). doi:10.3791/54150

Gritz, E., & Hirschi, K. K. (2016). Specification and function of hemogenic endothelium during embryogenesis. CELLULAR AND MOLECULAR LIFE SCIENCES, 73(8), 1547-1567. doi:10.1007/s00018-016-2134-0

Goligorsky, M. S., & Hirschi, K. (2016). Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells.. Advances in pharmacology (San Diego, Calif.), 77, 281-306. doi:10.1016/bs.apha.2016.04.007

Cuchiara, M. L., Coskun, S., Banda, O. A., Horter, K. L., Hirschi, K. K., & West, J. L. (2016). Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. BIOTECHNOLOGY AND BIOENGINEERING, 113(4), 870-881. doi:10.1002/bit.25848

Muralidharan, S., Sasi, S. P., Zuriaga, M. A., Hirschi, K. K., Porada, C. D., Coleman, M. A., . . . Goukassian, D. A. (2015). Ionizing particle radiation as a modulator of endogenous bone marrow cell reprogramming: implications for hematological cancers. FRONTIERS IN ONCOLOGY, 5. doi:10.3389/fonc.2015.00231

Muralidharan, S., Sasi, S. P., Zuriaga, M. A., Hirschi, K. K., Porada, C. D., Coleman, M. A., . . . Goukassian, D. A. (2015). Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers (vol 5, pg 231, 2015). FRONTIERS IN ONCOLOGY, 5. doi:10.3389/fonc.2015.00255

Martin, K. A., & Hirschi, K. K. (2014). The Magic Touch Endothelial Cells Muscle-Up Adipose. CIRCULATION RESEARCH, 115(9), 752-754. doi:10.1161/CIRCRESAHA.114.305030

Coskun, S., Chao, H., Vasavada, H., Heydari, K., Gonzales, N., Zhou, X., . . . Hirschi, K. K. (2014). Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells. CELL REPORTS, 9(2), 581-590. doi:10.1016/j.celrep.2014.09.013

Marcelo, K. L., Sills, T. M., Coskun, S., Vasavada, H., Sanglikar, S., Goldie, L. C., & Hirschi, K. K. (2013). Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control. DEVELOPMENTAL CELL, 27(5), 504-515. doi:10.1016/j.devcel.2013.11.004

Marcelo, K. L., Goldie, L. C., & Hirschi, K. K. (2013). Regulation of Endothelial Cell Differentiation and Specification. CIRCULATION RESEARCH, 112(9), 1272-1287. doi:10.1161/CIRCRESAHA.113.300506

Goldberg, J. S., Vadakkan, T. J., Hirschi, K. K., & Dickinson, M. E. (2013). A Computational Approach to Detect Gap Junction Plaques and Associate Them with Cells in Fluorescent Images. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 61(4), 283-293. doi:10.1369/0022155413477114

Vunjak-Novakovic, G., Bhatia, S., Chen, C., & Hirschi, K. (2013). HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. STEM CELL RESEARCH & THERAPY, 4. doi:10.1186/scrt369

Fang, J. S., Dai, C., Kurjiaka, D. T., Burt, J. M., & Hirschi, K. K. (2013). Connexin45 Regulates Endothelial-Induced Mesenchymal Cell Differentiation Toward a Mural Cell Phenotype. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(2), 362-+. doi:10.1161/ATVBAHA.112.255950

Agrawal, V., Siu, B. F., Chao, H., Hirschi, K. K., Raborn, E., Johnson, S. A., . . . Badylak, S. F. (2012). Partial Characterization of the Sox2+Cell Population in an Adult Murine Model of Digit Amputation. TISSUE ENGINEERING PART A, 18(13-14), 1454-1463. doi:10.1089/ten.tea.2011.0550

Hirschi, K. K. (2012). Hemogenic endothelium during development and beyond. BLOOD, 119(21), 4823-4827. doi:10.1182/blood-2011-12-353466