Camilla Wenceslau, Ph.D., M.S., FAHA

Hypertension Compromises Tissue-Resident Endothelial Progenitor Cells, Driving Impaired Vascular Regeneration and Highlighting Partial Reprogramming as a Therapeutic Strategy

I will present some preliminary data demonstrating a reduction in tissue-resident endothelial progenitor cells (EPCs) in hypertensive animals. I will show that hypertension-associated mechanical stretch compromises EPC function and regenerative capacity. Finally, I will discuss the potential of generating new EPC-like cells from endothelial cells as a strategy to restore vascular repair in hypertension.

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Associate Professor, Laboratory of Vascular Biology, Cardiovascular Translational Research Center, Department of Cell Biology and Anatomy, School of Medicine, Columbia University of South Carolina, SC