Lindner Lab

Robert M. Berne Cardiovascular Research Center
Division of Cardiovascular Medicine
University of Virginia Health System

Publications

  1. Ozawa K, Packwood W, Varlamov O, Muller M, xie A, Wu MD, Lopez JA, Chen JM, Lindner JR. Elevated low-density lipoprotein increases post-ischemic endothelial Von Willebrand factor and thromboinflammation in the myocardial microcirculation. Atheroscl Thromb Vasc Biol 2023 (in press).

  2. Hagen MW, Louey S, Alaniz SM, Belcik T, Muller MM, Brown L, Lindner JR, Jonker SS. Changes in microvascular perfusion of heart and skeletal muscle in sheep around the time of birth. Exp Physiol (in press).

  3. Wu M, Fields JJ, Sachdev V, Belcik JT, Chen J, Reed F, Fu X, Hodovan J, Harmann LM, Swistara G, Lindner JR. Increased susceptibility for adverse reactions to ultrasound contrast agents in sickle cell disease. J Am Soc Echoocardiogr 2022 (in press).

  4. Wilson RC, Lo JO, Lindner JR, Slayden OD, Roberts VHJ. Targeted ultrasound molecular imaging with phosphatidylserine microbubbles to detect placental inflammation in rhesus macaques. Biol Reproduction (in press).

  5. Hagen MW, Louey S, Alaniz SM, Brown L, Lindner JR. Jonker SS. Coronary conductance in the normal development of perinatal sheep. Am J Physiol Heart Circ Physiol (in press).

  6. Jensen JT, Leung P, Hodovan J, Roberts M, Guo J, Yao S, Mishler E, Grenz T, Slayden OD, Lindner JR. Systemic polidocanol from intravenous or pressurized intrauterine administration produces reversible cardiovascular toxicity. J Vasc Science 2022;08:002.

  7. Roldan R, Ravi S, Hodovan J, Belcik JT, Heitner SB, Masri A, Lindner JR. Myocardial contrast echocardiography assessment of perfusion abnormalities in hypertrophic cardiomyopathy. Cardiovasc Ultrasound 2022;20:23.

  8. Muller MA, Hodovan J, Ozawa K, Hagen MW, Hobbs TR, Templon J, Zhao Y, Kaufman JA, Lindner JR. Augmentation of pulmonary perfusion by conducted effects of a pulmonary artery ultrasound catheter. Ultrasound Med Biol 2022;48:2146-2153.

  9. Ozawa K, Packwood W, Varlamov O, Muller M, Xie A, Lopez JA, Lindner JR. Reduced proteolytic cleavage of von Willebrand factor predisposes to aortic valve thickening and stenosis. JACC Basic Transl Sci 2022;7:641-655.

  10. Desai AK, Hodovan J, Belcik JT, Lindner JR. Hypersensitivity cross-reactivity for ultrasound enhancing agents and COVID-19 vaccines. J Am Soc Echocardiogr 2022;35:523-525.

  11. Kohs TCL, Olson SR, Pang J, Jordan KR, Zheng TJ, Xie A, Hodovan J, Muller M, McArthur C, Johnson J, Sousa BB, Wallisch M, Kievit P, Aslan JE, Seixas JD, Bernardes GJL, Hinds MT, Lindner JR, McCarty OJT, Puy C, Shatzel JJ. Effect of BTK inhibitors on endothelial activity in vitro and dysfunction in atherosclerosis-prone arteries of obese nonhuman primates in vivo. Cell Molec Bioengin 2022;15:231-243.

  12. Soman D, Hodovan J, Macon CJ, Davidson BP, Belcik JT, Mudd JO, Lindner JR. Improvement in skeletal muscle recruitable perfusion is associated with functional improvement after left ventricular assist device. J Am Soc Echocardiogr 2022;35:495-502.

  13. Aberdeen GW, Babischkin JS, Lindner JR, Pepe GJ, Albrecht ED. Placental sFlt-1 Gene Delivery in Early Primate Pregnancy Suppresses Uterine Spiral Artery Remodeling. Endocrinology 2022;163:bqac012.

  14. Davidson BP, Hodovan J, Layoun ME, Golwala H, Zahr F, Lindner JR. Echocardiographic ischemic memory molecular imaging for point-of-care detection of myocardial ischemia. J Am Coll Cardiol 2021;78:1990-2000.

  15. Muller MA, Belcik JT, Hodovan J, Ozawa K, Brown E, Powers J, Sheeran PS, Lindner JR. Augmentation of tissue perfusion with contrast ultrasound: influence of 3-D beam geometry and conducted vasodilation. J Am Soc Echocardiogr 2021;34:887-895.

  16. Brown E, Ozawa K, Moccetti F, Vinson A, Hodovan J, Xie A, Bader L, Lopez JA, Kievit P, Shaw GD, Chung DW, Osborn W, Fu X, Chen J, Lindner JR. Arterial platelet adhesion in atherosclerosis-prone arteries of obese, insulin-resistant non-human primates. J Am Heart Assoc 2021;10:e019413.

  17. Nazer B, Giraud D, Zhao Y, Hodovan J, Elman MR, Masri A, Gerstenfeld EP, Lindner JR. High-intensity ultrasound catheter ablation achieves deep mid-myocardial lesions in vivo. Heart Rhythm 2021;18:623-631.

  18. Muller MA, Ozawa K, Hagen MW, Giraud DSH, Qi Y, Xie A, Hobbs TR, Sheeran PS, Lindner JR. Treatment of limb ischemia with conducted effects of catheter-based endovascular ultrasound. Ultrasound Med Biol 2021;47:2277-2285.

  19. Shentu W, Ozawa K, Nguyen T, Wu MD, Packwood W, Xie A, Muller M, Brown E, Hagen MW, Lopez JA, Lindner JR. Imaging arterial thromboinflammation and treatment response to IL-1b-inhibition in atherosclerosis. J Am Soc Echocardiogr 2021;34:433.

  20. Lindner JR, Davidson BP, Song Z, Maier CS, Minnier J, Stevens JF, Ferencik M, Taqui S, Belcik JT, Moccetti F, Layoun M, Spellman P, Turker MS, Tavori H, Fazio S, Raber S, Bobe G. Plasma lipid and lipidomic patterns in patients with symptomatic coronary microvascular dysfunction. Metobolites 2021;11:648.

  21. Nazer B, Giraud D, Zhao Y, Qi Y, Mason O, Jones PD, Diederich CJ, Gertensfeld EP, Lindner JR. Microbubble-facilitated ultrasound catheter ablation causes microvascular damage and fibrosis. Ultrasound Med Biol 2021;47:131-138.

  22. Rader F, Rashid MA, Ngyen TT, Luong E, Kim A, Elashhoff R, Davoren K, Moy NB, Nafeh F, Bairey-Merz CN, Ebinger JE, Hamburg HM, Lindner JR, Cheng S. E-cigarette use and subclinical cardiac effects. Circ Res 2020;127:1566.

  23. Ozawa K, Miller MA, Varlamov O, Tavori H, Packwood W, Mueller P, Xie A, Wu MD, Ruggeri Z, Chung D, Lopez JA, Lindner JR. Pro-inflammatory endothelial activation from von Willebrand factor-mediated platelet adhesion in atherosclerosis. JACC Basic Transl Sci 2020;5:1017-1028.

  24. Wu MD, Hodovan J, Kumar K, Moulton B, Olson S, Gilbert A, Wood MD, Lindner JR. Ponatinib coronary microangiopathy: Novel bedside diagnostic approach and management with n-acetylcysteine. Blood Adv 2020;4:4083-4085.

  25. Moccetti F, Belcik T, Latifi Y, Xie A, Ozawa K, Brown E, Davidson BP, Packwood W, Ammi A, Huke S, Lindner JR. Flow augmentation in the myocardium by ultrasound cavitation of microbubbles: role of shear-mediated purinergic signaling. J Am Soc Echocardiogr 2020;33:1023-1031.

  26. Muller MA, Xie A, Qi Y, Zhao Y, Ozawa K, Lindner JR. Regional and conducted vascular effects of endovascular ultrasound catheters. Ultrasound Med Biol 2020;46:2361-2369.

  27. Mason OR, Davidson BR, Sheeran P, Muller M, Hodovan JM, Sutton J, Powers J, Lindner JR. Augmentation of tissue perfusion in patients with peripheral artery disease by microbubble cavitation. JACC Cardiovasc Imag 2020;13:641-651.

  28. Steinbach RJ, Haese NN, Smith JL, Colgin LMA, MacAllister RP, Greene JM, Parkins CJ, Kempton JB, Porsov E, Wang X, Renner LM, McGill TJ, Dozier BL, CN Kreklywich, Andoh TF, Grafe MR, Pecoraro HL, Hodge T, Friedman RM, Houser LA, Morgan TK, Stenzel P, Lindner JR, RL Schelonka, Sacha JB; Roberts VHJ, Neuringer M, Brigande JV, Kroenke CD, Frias AE, Lewis AD, Kelleher MA, Hirsch AJ, Streblow DN. A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy. PLOS ONE 2020;15:e0227676.

  29. Nabavizadeh N, Qi Y, Kaempf A, Chen Y, Tanyi JA, Lindner JR, Wu ME. Contrast-Enhanced Ultrasound to Detect Early Microvascular Changes in Skeletal Muscle After High-Dose Radiation Therapy. Radiat Res 2020;193:155-160.

  30. Torres ERS, Hall R, Bobe G, Choi J, Impey S, Pelz C, Lindner JR, Stevens JF, Raber J. Integrated metabolomics-DNA methylation analysis reveals significant long-term tissue-dependent directional alterations in aminoacyl-tRNA biosynthesis in the left ventricle of the heart and hippocampus following proton irradiation. Front Mol Biosc 2019;10:77.

  31. Davidson BP, Hodovan J, Mason OR, Moccetti F, Gupta A, Muller M, Belcik JT, Annex BH, Lindner JR. Limb perfusion during exercise assessed by contrast ultrasound varies according to symptom severity in patients with peripheral artery disease. J Am Soc Echocardiogr 2019;32:1086-1094.

  32. Wu M, Moccetti F, Brown E, Davidson BP, Atkinson T, Belcik JT, Giraud G, Tsimikas S, Duell PB, Fazio S, Tavori H, Lindner JR. Lipoprotein apheresis acutely reverses coronary microvascular dysfunction in patients with severe hypercholesterolemia. JACC Cardiovasc Imag 2019;12:1430-1440.

  33. Lindner JR, Belcik T, Widlansky M, Harmann LH, Wandersee NJ, Puligandla M, Neuberg D, Linden J, Field JJ. Contrast ultrasound detects changes in microvascular blood flow in adults with sickle cell disease. PLOS ONE;2019;14:e0218783.

  34. Babischkin JS, Aberdeen GW, Lindner JR, Bonagura TW, Pepe GJ, Albrecht ED. Vascular endothelial growth factor delivery to placental basal plate promotes uterine artery remodeling in the primate. Endocrinol 2019;160:1492-1505.

  35. Taqui S, Ferencik M, Davidson BP, Belcik JT, Moccetti F, Raber J, Turker M, Layoun M, Lindner JR. Coronary microvascular dysfunction by myocardial contrast echocardiography in non-elderly patients referred for CT coronary angiography. J Am Soc Echocardiogr 2019;32:817-825.

  36. Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, Ozawa K, Shentu W, Brown E, Shirai T, McCarty OJ, Ruggeri Z, Moslehi J, Chen J, Druker BJ, Lopez JA, Lindner JR. Platelet-mediated thrombotic microangiopathy as a cause for cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib. Blood 2019;133:1597-1606.

  37. Walsh L, Ghiarone T, Olver TD, Medina-Hernandez A, Edwards JC, Thorne PK, Emter C, Lindner JR, Manrique-Acevedo C, Martinez-Lemus L, Padilla J. Increased endothelial shear stress improves insulin-stimulated vasodilation in skeletal muscle. J Physiol 2019;597.1:57-69.

  38. Ozawa K, Packwood W, Varlamov O, Qi Y, Xie A, Wu MD, Ruggeri Z, Lopez J, Lindner JR. Molecular imaging of Von Willebrand factor and platelet adhesion in post-ischemic impaired microvascular reflow. Circ Cardiovasc Imaging 2018;11:e007913.

  39. Salati J, Roberts V, Schabel M, Lo J, Kroenke C, Lewandowski K, Lindner J, Grove K, Frias A. Diet modification in the Japanese macaque alters placental perfusion kinetics as demonstrated by contrast-enhanced ultrasound. Intl J Obesity 2019;43:906-916.

  40. Atkinson T, Packwood W, Xie A, Liang S, Qi Y, Ruggeri Z, Lopez J, Davidson BP, Lindner JR. Assessment of novel antioxidant therapy in atherosclerosis by contrast ultrasound molecular imaging. J Am Soc Echocardiogr 2018;31:1252-1259.

  41. Moccetti F, Brown E, Packwood W, Qi Y, Ruggeri Z, Chen J, Lopez J, Lindner JR. Myocardial infarction produces sustained pro-inflammatory endothelial activation in remote arteries. J Am Coll Cardiol 2018;72:1015-1026.

  42. Weinkauf CC, Concha-Moore K, Lindner JR, Marinelli ER, Hadinger KP, Bhattacharjee S, Berman SS, Goshima K, Leon LR Jr, Matsunaga TO, Unger E. Endothelial VCAM-1 is a marker for high-risk carotid plaques and target for ultrasound molecular imaging. J Vasc Surg 2018;S0741-5214:32689-7

  43. Moccetti F, Weinkauf CC, Davidson BP, Belcik JT, Marinellia ER, Unger E, Lindner JR. Ultrasound molecular imaging of atherosclerosis using small-peptide ligands against endothelial markers of inflammation and oxidative stress. Ultrasound Med Biol 2018;44:1155-1163.

  44. Sachdev V, Sidenko S, Hannoush, H, Wu MD, Brenneman CL, Minniti CP, Waclawiw MA, Arai AE, Schechter AN, Kato GJ, Lindner JR. Microvascular flow in sickle cell disease patients on hydroxyurea. Br J Haematol 2017;179:648-656.

  45. Oehler AC, Minnier J, Lindner JR. Increased Coronary Tortuosity Is Associated with Increased Left Ventricular Longitudinal Myocardial Shortening. J Am Soc Echocardiogr 2017;30:1028-1034.

  46. Davidson BP, Belcik JT, Landry G, Linden J, Lindner JR. Exercise versus vasodilator stress limb perfusion imaging for the assessment of peripheral artery disease. Echocardiography 2017;34:1187-1194.

  47. Davidson BP, Hodovan J, Belcik JT, Moccetti F, Xie A, Ammi A, Lindner JR. Rest-stress limb perfusion imaging in humans with contrast ultrasound using intermediate-power imaging and microbubbles resistant to inertial cavitation. J Am Soc Echocardiogr 2017;30:503-510.

  48. Belcik, JT, Davidson BP, Xie A, Yadava M, Wu MD, Qi Y, Liang S, Chon CR, Ammi AY, Field J, Harmann L, Chilian WM, Linden J, Lindner JR. Augmentation of muscle blood flow by ultrasound cavitation is mediated by ATP and purinergic signaling. Circulation 2017;135:1240-1252.

  49. Jonker SS, Davis L, Soman D, Belcik JT, Davidson BP, Atkinson TM, Wilburn A, Louey S, Giraud GG, Lindner JR. Functional adaptations of the coronary microcirculation to anemia in fetal sheep. J Physiol 2016;594:6165-6174.

  50. Xie A, Wu MD, Cigarroa G, Belcik JT, Ammi A, Moccetti F, Lindner JR. Influence of DNA-microbubble coupling on contrast ultrasound-mediated gene transfection in muscle and liver. J Am Soc Echocardiogr 2016;29:812-818.

  51. Chadderdon SM, Belcik JT, Bader L, Kievit KL, Grove KL, Lindner JR. Vasoconstrictor eicosanoids and impaired microvascular function in inactive and insulin resistant primates. Int J Obesity 2016;40:1600-1603.

  52. Mott B, Packwood W, Xie A, Belcik JT, Taylor RP, Zhao Y, Davidson BP, Lindner JR. Echocardiographic ischemic memory imaging through complement-mediated vascular adhesion of phosphatidylserine-containing microbubbles. J Am Coll Cardiol Cardiovasc Imag 2016;9:937-46.

  53. Chadderdon SM, Belcik JT, Bader L, Peters D, Kievit P, Alkayed NJ, Kaul S, Grove KL, Lindner JR. Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance. Diabetes 2016;65:2249-57.