Lindner Lab

Robert M. Berne Cardiovascular Research Center
Division of Cardiovascular Medicine
University of Virginia Health System

Mission Statement

The Lindner Lab at the Robert M. Berne Cardiovascular Research Center operates at the intersections of non-invasive imaging, cardiovascular physiology, and cell biology. The laboratory is composed of a multidisciplinary team of investigators with expertise in vascular biology, non-invasive imaging, microvascular physiology, and acoustic physics. This combination of skills has allowed us to develop novel methods for molecular imaging, perfusion imaging, and cardiovascular functional imaging to better understand disease pathophysiology and treatment effects. We have used non-invasive imaging to discover new therapeutic targets, and to develop novel diagnostic algorithms that can improve patient care. Specific areas of research include: a) application of molecular imaging techniques to characterize pathophysiology and assess therapy for atherosclerotic, vascular, and valvular disease; b) coronary and peripheral microvascular function in health and disease;; d) development of ultrasound-based therapies based on site-targeted gene or drug delivery, and vascular bioeffects of cavitation.

    Our primary goals are to:

  1. To develop novel non-invasive imaging tools
  2. To use advanced cardiovascular imaging, including molecular imaging, to characterize pathobiology and develop novel therapeutic
  3. To improve health care through ultrasound-based therapeutics
Research
To find out more about our research, click here.
Members
To learn about our lab members, click here.
Publications
To see our most recent publications, click here.

Selected High-Impact Publications

  1. Ozawa K, Packwood W, Varlamov O, Muller M, Xie A, Lopez JA, Lindner JR. Reduced proteolytic cleavage of von Willebrand factor predisposes to aortic valve thickening and stenosis. JACC Basic Transl Sci 2022;7:641-655.

  2. Desai AK, Hodovan J, Belcik JT, Lindner JR. Hypersensitivity cross-reactivity for ultrasound enhancing agents and COVID-19 vaccines. J Am Soc Echocardiogr 2022;35:523-525.

  3. Davidson BP, Hodovan J, Layoun ME, Golwala H, Zahr F, Lindner JR. Echocardiographic ischemic memory molecular imaging for point-of-care detection of myocardial ischemia. J Am Coll Cardiol 2021;78:1990-2000.

  4. Ozawa K, Miller MA, Varlamov O, Tavori H, Packwood W, Mueller P, Xie A, Wu MD, Ruggeri Z, Chung D, Lopez JA, Lindner JR. Pro-inflammatory endothelial activation from von Willebrand factor-mediated platelet adhesion in atherosclerosis. JACC Basic Transl Sci 2020;5:1017-1028.

  5. Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, Ozawa K, Shentu W, Brown E, Shirai T, McCarty OJ, Ruggeri Z, Moslehi J, Chen J, Druker BJ, Lopez JA, Lindner JR. Platelet-mediated thrombotic microangiopathy as a cause for cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib. Blood 2019;133:1597-1606.

Professional Affiliations

  1. American College of Cardiology
  2. American Heart Association
  3. American Society of Echocardiography
  4. American Society for Clinical Investigation
  5. Association of University Cardiologists
  6. National Board of Echocardiography

Laboratory Trainee Honors

2005 Michelle Vincent, Finalist: Young Investigator Award, American Society of Echocardiography 16th Annual Scientific Sessions
2007 Beat Kaufmann, Winner: Young Investigator Award, American Society of Echocardiography 18th Annual Scientific Sessions
2009 Chad Carr, Winner: Young Investigator Award, American Society of Echocardiography 20th Annual Scientific Sessions
2011 Scott Chadderdon, Winner: Young Investigator Award, American Society of Echocardiography 22th Annual Scientific Sessions
2013 Brian Davidson, Winner: American College of Cardiology Parmley Prize
2014 Chi Young Shim, Winner: Young Investigator Award, American Society of Echocardiography 25th Annual Scientific Sessions
2017 Federico Moccetti, Winner: Young Investigator Award, American Society of Echocardiography 28th Annual Scientific Sessions
2018 Koya Ozawa, Finalist: Young Investigator Award, Japanese Society of Echocardiography 31st Annual Scientific Meeting
2018 Yllka Latifi, Winner: Young Investigator Award, European Association of Cardiovascular Imaging 2018 Scientific Sessions
2019 Koya Ozawa, Finalist: Young Investigator Award, American Society of Echocardiography 30th Annual Scientific Sessions
2019 Koya Ozawa, Finalist: Young Investigator Award, European Association of Cardiovascular Imaging 2019 Scientific Sessions
2020 O’Neil Mason, Winner: American College of Cardiology 2019 Young Author Achievement Award.
2022 Matthew Muller, Winner: Alan Pearlman Research Award, American Society of Echocardiography 33rd Annual Scientific Sessions.

External Collaborators

Jose Lopez, MD Bloodworks NW, Seattle, WA
Junmei Chen, PhD Bloodworks NW, Seattle WA
James Thomas, MD Northwestern University, Chicago, IL
Jessoo Lee, PhD Northwestern University, Chicago, IL
Michael Markle, PhD Northwestern University, Chicago, IL
Benjamin Levine, MD University of Texas Southwestern, Dallas TX
Michael Bungo, MD University of Texas Houston, Houston, TX