I am a Cardiologist and Cardiovascular Researcher focused on the molecular basis of cardiomyopathies. After completing the Medical Scientist Training Program (MSTP) at Washington University School of Medicine, a Medicine residency and Cardiology fellowship at Duke University Medical Center, and establishing an independent research laboratory at Duke, I joined the University of Virginia. I am an Associate Professor of Medicine in the Division of Cardiovascular Medicine, and a resident faculty member of the Robert M. Berne Cardiovascular Research Center, caring for patients and continuing an active research laboratory. I believe the interface between clinical cardiology and basic research provides exciting opportunities to discover new insights into cardiac pathophysiology.

Leigh has been at UVA for over 20 years. She ensures the lab operates smoothly by managing the lab inventory and equipment, as well as, processing orders for supplies for the entire lab. She regularly trains students and new lab members in safety and lab procedures as well as bench techniques. She manages the mouse colony while developing new genetic lines for research. She has extensive knowledge in molecular biology ranging from proteomics and nucleic acids to culturing cells to animal models.

Selected Publications

Young, A. Bradley, L.A., Farrar, E., Bilcheck, H.O., Tkachenko, S., Saucerman, J.J., Bekiranov, S., and Wolf, M.J. (2022) Inhibition of DYRK 1a Enhances Cardiomyocyte Cycling after Myocardial Infarction. Circ Res. Apr

Young A, Bradley LA, Wolf MJ. In Vivo Methods to Monitor Cardiomyocyte Proliferation. J Cardiovasc Dev Dis. 2022 Mar 3;9(3):73.

Bradley, L.A., Young, A., Li, H. Billcheck, H.O. and Wolf, M.J. (2021) Loss of Endogenously Cycling Adult Cardiomyocytes Worsens Myocardial Function. Circ Res. 128 (2):155-168

Brodrick B, Vidrich A, Porter E, Bradley L, Buzan JM, Cohn SM. Fibroblast growth factor receptor-3 (FGFR-3) regulates expression of paneth cell lineage-specific genes in intestinal epithelial cells through both TCF4/beta-catenin-dependent and -independent signaling pathways. J Biol Chem. 2011 May 27;286(21):18515-25.

Vidrich A, Buzan JM, Brodrick B, Ilo C, Bradley L, Fendig KS, Sturgill T, Cohn SM. Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal development. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G168-78Vidrich A, Buzan JM, Ilo C, Bradley L, Skaar K, Cohn SM. Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis. Dev Dyn. 2004 May;230(1):114-23.