A) Calcium signals in smooth muscle cells from a vein.

B) A dSTORM superresolution image showing alpha1 adrenergic receptors in an arterial smooth muscle cell. The insert indicates a widefield image.

C) Calcium signals in smooth muscle cells from an artery pressurized to 80 mm Hg.

D) Calcium signals at endothelial projections to smooth muscle cell (black holes) in the arterial wall.

E) TRPV4 sparklets (calcium influx signals through TRPV4 ion channels) in endothelial cells from pulmonary arteries.

E) TRPV4 sparklets (calcium influx signals through TRPV4 ion channels) in endothelial cells from pulmonary arteries.