Michael B. Lawrence
- Email: mbl2a@virginia.edu
- Phone: 434-982-4269
Primary Appointment
Associate Professor, Biomedical Engineering
Education
- BA, Chemistry, Rice University
- PhD, Chemical Engineering, Rice University
- Postdoc, Immunology, Harvard University
Research Disciplines
Biophysics, Biotechnology, Cardiovascular Biology, Cardiovascular Biology
Research Interests
Vascular and Molecular Engineering
Research Description
Additionally, we have developed several model flow systems to examine the dynamics of platelet-leukocyte-vessel wall interactions that take place during the acute phases of an inflammatory challenge or the formation of blood clots on the vessel wall. Common to interactions between platelets, leukocytes, and the vessel wall is the involvement of a family of receptors called selectins that support transient adhesions in which leukocytes and platelets roll along the vessel wall in shear flow. These studies have significance for the understanding of the regulatory effects of blood flow, adhesion receptor expression, and chemokines on inflammatory responses and blood clotting.
Personal Statement
Additionally, we have developed several model flow systems to examine the dynamics of platelet-leukocyte-vessel wall interactions that take place during the acute phases of an inflammatory challenge or the formation of blood clots on the vessel wall. Common to interactions between platelets, leukocytes, and the vessel wall is the involvement of a family of receptors called selectins that support transient adhesions in which leukocytes and platelets roll along the vessel wall in shear flow. These studies have significance for the understanding of the regulatory effects of blood flow, adhesion receptor expression, and chemokines on inflammatory responses and blood clotting.
Selected Publications
2016
Viola, F., Lin-Schmidt, X., Bhamidipati, C., Haverstick, D. M., Walker, W. F., Ailawadi, G., & Lawrence, M. B. (2016). Sonorheometry assessment of platelet function in cardiopulmonary bypass patients: Correlation of blood clot stiffness with platelet integrin αIIbβ3 activity, aspirin usage, and transfusion risk. THROMBOSIS RESEARCH, 138, 96-102. doi:10.1016/j.thromres.2015.11.036
2015
Wang, C. W., Perez, M. J., Helmke, B. P., Viola, F., & Lawrence, M. B. (2015). Integration of Acoustic Radiation Force and Optical Imaging for Blood Plasma Clot Stiffness Measurement. PLOS ONE, 10(6). doi:10.1371/journal.pone.0128799
Paschall, C. D., Klibanov, A. L., & Lawrence, M. B. (2015). Regulation of L-selectin-dependent hydrodynamic shear thresholding by leukocyte deformability and shear dependent bond number. BIORHEOLOGY, 52(5-6), 415-432. doi:10.3233/BIR-15064
2012
Tlaxca, J. L., Rychak, J. J., Ernst, P. B., Konkalmatt, P. R., Shevchenko, T. I., Pizzaro, T. T., . . . Lawrence, M. B. (2013). Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. JOURNAL OF CONTROLLED RELEASE, 165(3), 216-225. doi:10.1016/j.jconrel.2012.10.021
2011
Lin-Schmidt, X., Ham, A. S. W., Reed, M. L., Lawrence, M. B., & Helmke, B. P. (2011). Leukocyte rolling on engineered nanodot surfaces. MICRO & NANO LETTERS, 6(5), 301-305. doi:10.1049/mnl.2011.0184
2010
Tlaxca, J. L., Anderson, C. R., Klibanov, A. L., Lowrey, B., Hossack, J. A., Alexander, J. S., . . . Rychak, J. J. (2010). ANALYSIS OF IN VITRO TRANSFECTION BY SONOPORATION USING CATIONIC AND NEUTRAL MICROBUBBLES. ULTRASOUND IN MEDICINE AND BIOLOGY, 36(11), 1907-1918. doi:10.1016/j.ultrasmedbio.2010.05.014
Mauldin, F. W. J., Viola, F., Hamer, T. C., Ahmed, E. M., Crawford, S. B., Haverstick, D. M., . . . Walker, W. F. (2010). Adaptive force sonorheometry for assessment of whole blood coagulation. CLINICA CHIMICA ACTA, 411(9-10), 638-644. doi:10.1016/j.cca.2010.01.018