Brian H. Annex


Primary Appointment

Lantheus Medical Imaging Distinguished Professor of Cardiovascular Medicine; Chief, Division of Cardiovascular Medicine, Medicine- Cardiovascular Medicine


  • Clinical Fellowship, Cardiology, Duke University School of Medicine, Durham, NC
  • Clinical Fellowship, Interventional Cardiology, William Beaumont Hospital
  • MD, Yale School of Medicine
  • Residency, Internal Medicine, Tufts University School of Medicine

Research Disciplines

Cardiovascular Biology

Research Interests

Angiogenesis; peripheral arterial disease (PAD); gene therapy

Research Description

Dr. Annex's clinical and research interests include a multidisciplinary program in angiogenesis (the growth of new blood vessels) that is focused mainly on peripheral arterial disease (PAD), in which blockages in arteries cause a series of clinical problems. His group is involved in a number of bench-to-bedside studies, including investigations of the causes of blockages in arteries outside the heart, in case of the legs the response of the muscle and new arterial growth that follow the blockages, and the impact that diabetes mellitus plays in PAD. Included among the array studies are gene or cell therapy clinical investigation to promote blood vessel growth in patients with PAD, as well as studies of exercise training, and pre-clinical models of PAD.

Personal Statement

Brian Annex, M.D., is board certified in internal medicine, cardiovascular diseases and interventional cardiology. Prior to his arrival at UVA in July 2008, Dr. Annex served as Professor of Medicine in the Division of Cardiovascular Medicine at Duke University School of Medicine. While at Duke, he also served as Vice Chief for the Division of Cardiovascular Medicine. He initiated and then served as Director of Vascular Medicine at Duke as well as a staff cardiologist at the Durham Veterans Administration Medical Center.
Dr. Annex has a long-standing clinical and research interest in peripheral arterial disease (PAD). In addition, Annex's research includes understanding the impact of diabetes has among the major risk factors for PAD; the genetics of PAD; links between PAD and coronary artery disease; and novel PAD treatments including gene and cell therapy. He has performed and led numerous studies on angiogenesis (the growth of new blood vessels) and gene therapy to treat several diseases, including PAD. Dr. Annex brings a number of pre-clinical and clinical studies on PAD and angiogenesis, which are funded by the National Institutes of Health (NIH) as well as the American Diabetes Association. He has served on several national programs in PAD. He serves as the Chair on the NIH Study Section on Clinical and Integrative Cardiovascular Sciences.

Selected Publications

French BA, Annex BH, AAV9 and Cre: a one-two punch for a quick cardiac knockout., 2014; Cardiovascular research. () . PMID: 25187523

Okello S, Millard A, Owori R, Asiimwe SB, Siedner MJ, Rwebembera J, Wilson LA, Moore CC, Annex BH, Prevalence of lower extremity peripheral artery disease among adult diabetes patients in southwestern Uganda., 2014; BMC cardiovascular disorders. 14() 75. PMID: 24913468 | PMCID: PMC4057935

Nehler MR, Duval S, Diao L, Annex BH, Hiatt WR, Rogers K, Zakharyan A, Hirsch AT, Epidemiology of peripheral arterial disease and critical limb ischemia in an insured national population., 2014; Journal of vascular surgery. 60(3) 686-695.e2. PMID: 24820900

Naresh NK, Chen X, Roy RJ, Antkowiak PF, Annex BH, Epstein FH, Accelerated dual-contrast first-pass perfusion MRI of the mouse heart: Development and application to diet-induced obese mice., 2014; Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. () . PMID: 24760707

Meisner JK, Annex BH, Price RJ, Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice., 2014; Journal of vascular surgery. () . PMID: 24582703 | PMCID: PMC4147032

Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Peirce-Cottler SM, Rembold CM, Annex BH, Yan Z, Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure., 2014; Circulation. Heart failure. 7(3) 519-30. PMID: 24523418 | PMCID: PMC4080303

Dokun AO, Chen L, Lanjewar SS, Lye RJ, Annex BH, Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD., 2014; Cardiovascular research. 101(3) 364-72. PMID: 24385342 | PMCID: PMC3928005

Mohler ER, Hiatt WR, Gornik HL, Kevil CG, Quyyumi A, Haynes WG, Annex BH, Sodium nitrite in patients with peripheral artery disease and diabetes mellitus: safety, walking distance and endothelial function., 2013; Vascular medicine (London, England). 19(1) 9-17. PMID: 24363302

Allen JD, Stabler T, Kenjale AA, Ham KL, Robbins JL, Duscha BD, Kraus WE, Annex BH, Diabetes status differentiates endothelial function and plasma nitrite response to exercise stress in peripheral arterial disease following supervised training., 2013; Journal of diabetes and its complications. 28(2) 219-25. PMID: 24355663 | PMCID: PMC3943470

Meisner JK, Song J, Annex BH, Price RJ, Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis., 2013; The American journal of pathology. 183(6) 1710-8. PMID: 24095922 | PMCID: PMC5746951