Jeffrey W. Holmes

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Primary Appointment

Professor, Biomedical Engineering

Research Disciplines

Bioinformatics and Genomics, Biotechnology, Cardiovascular Biology, Computational Biology, Physiology, Translational Science

Personal Statement

The Cardiac Biomechanics Group focuses on the interactions between mechanics, function, and growth and remodeling in the heart. The mechanical properties of normal and diseased myocardium are important determinants of overall heart function. These mechanical properties change during growth, remodeling or disease, often in part as a response to changes in the mechanical environment. Our group studies this interplay between mechanical environment, tissue response, and heart function, not only to better understand the basis for heart disease but also to identify new opportunities to intervene. Current Projects:
Currently, most of our projects are related to myocardial infarction (MI):
1. a translational effort to help prevent MI by developing new quantitative measures of heart wall motion that improve screening for coronary artery disease;
2. a basic biomechanics project focused on understanding how the structure of a healing infarct gives rise to its mechanical properties and how those mechanical properties influence overall heart function; and
3. longer-term efforts to determine how mechanical factors regulate both cardiac wound healing and remodeling of non-infarcted myocardium in post-MI patients

Training

  • Biotechnology Training Grant
  • Training in Cell and Molecular Biology
  • Training in the Pharmacological Sciences

Selected Publications

Rouillard AD, Holmes JW, Mechanical boundary conditions bias fibroblast invasion in a collagen-fibrin wound model., 2014; Biophysical journal. 106(4) 932-43. PMID: 24559996 | PMCID: PMC3945786

Parker KM, Clark AP, Goodman NC, Glover DK, Holmes JW, Comparison of Quantitative Wall-Motion Analysis and Strain for Detection of Coronary Stenosis with Three-Dimensional Dobutamine Stress Echocardiography., 2014; Echocardiography (Mount Kisco, N.Y.). () . PMID: 24815588 | PMCID: PMC4415736

Haggart CR, Ames EG, Lee JK, Holmes JW, Effects of stretch and shortening on gene expression in intact myocardium., 2013; Physiological genomics. 46(2) 57-65. PMID: 24302644 | PMCID: PMC3921349

Fomovsky GM, Clark SA, Parker KM, Ailawadi G, Holmes JW, Anisotropic reinforcement of acute anteroapical infarcts improves pump function., 2012; Circulation. Heart failure. 5(4) 515-22. PMID: 22665716 | PMCID: PMC3412161

Rouillard AD, Holmes JW, Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts., 2012; The Journal of physiology. 590(0) 4585-602. PMID: 22495588 | PMCID: PMC3477759

Fomovsky GM, Rouillard AD, Holmes JW, Regional mechanics determine collagen fiber structure in healing myocardial infarcts., 2012; Journal of molecular and cellular cardiology. 52(5) 1083-90. PMID: 22418281 | PMCID: PMC3328210

Holmes JW, Vande Geest JP, Cardiovascular solid mechanics grows and remodels., 2011; Journal of biomechanics. 45(5) 727. PMID: 22153750

Holmes JW, Williams MD, Methicillin-resistant staphylococcus aureus screening and eradication in the surgical intensive care unit: Is it worth it?, 2010; American journal of surgery. 200(6) 827-30; discussion 830-1. PMID: 21146028

Fomovsky GM, Macadangdang JR, Ailawadi G, Holmes JW, Model-based design of mechanical therapies for myocardial infarction., 2010; Journal of cardiovascular translational research. 4(1) 82-91. PMID: 21088945 | PMCID: PMC3328213

Duan Q, Parker KM, Lorsakul A, Angelini ED, Hyodo E, Homma S, Holmes JW, Laine AF, QUANTITATIVE VALIDATION OF OPTICAL FLOW BASED MYOCARDIAL STRAIN MEASURES USING SONOMICROMETRY., 2010; Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging. 2009() 454-457. PMID: 20694163 | PMCID: PMC2916658

Fomovsky GM, Holmes JW, Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat., 2009; American journal of physiology. Heart and circulatory physiology. 298(1) H221-8. PMID: 19897714 | PMCID: PMC2806135

Quinn TA, Cabreriza SE, Richmond ME, Weinberg AD, Holmes JW, Spotnitz HM, Simultaneous variation of ventricular pacing site and timing with biventricular pacing in acute ventricular failure improves function by interventricular assist., 2009; American journal of physiology. Heart and circulatory physiology. 297(6) H2220-6. PMID: 19855057 | PMCID: PMC2793134

Fomovsky GM, Thomopoulos S, Holmes JW, Contribution of extracellular matrix to the mechanical properties of the heart., 2009; Journal of molecular and cellular cardiology. 48(3) 490-6. PMID: 19686759 | PMCID: PMC2823835

Lee WN, Ingrassia CM, Fung-Kee-Fung SD, Costa KD, Holmes JW, Konofagou EE, Theoretical quality assessment of myocardial elastography with in vivo validation., 2007; IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 54(11) 2233-45. PMID: 18051158