David K. Glover


Primary Appointment

Associate Professor of Research, Medicine- Cardiovascular Medicine


  • BS, Randolph College
  • PhD, Physiology, University of Virginia

Research Interests

Nuclear Cardiology

Research Description

The focus of research in our experimental laboratory is noninvasive molecular imaging in the cardiovascular system using targeted radioisotopes. One of the unique strengths of our laboratory is the wide array of novel radiotracers that we have available through our own development efforts, as well as those obtained through collaborations with radiochemists and biotech companies. These tracers can be used to characterize and measure biological processes in living animals at the cellular and molecular level using a conventional clinical SPECT or PET camera. Using this instrumentation and these targeted tracers, we can measure perfusion (i.e. blood flow), inflammation (white blood cell localization), or metabolism in the heart and lungs as well as a number of other physiologic and functional parameters.
Quantitative techniques allow us to measure and follow these processes over time and can be used to determine the efficacy of a particular therapy. Furthermore, because the instrumentation that is used is readily available in the hospital setting, the procedures and techniques that we develop are readily translatable to human studies.

Personal Statement

Nuclear Cardiology

Selected Publications

Parker KM, Clark AP, Goodman NC, Glover DK, Holmes JW, Comparison of Quantitative Wall-Motion Analysis and Strain for Detection of Coronary Stenosis with Three-Dimensional Dobutamine Stress Echocardiography., 2014; Echocardiography (Mount Kisco, N.Y.). () . PMID: 24815588 | PMCID: PMC4415736

Broisat A, Ruiz M, Goodman NC, Hanrahan SM, Reutter BW, Brennan KM, Janabi M, Schaefer S, Watson DD, Beller GA, VanBrocklin HF, Glover DK, Myocardial uptake of 7'-(Z)-[(123)I]iodorotenone during vasodilator stress in dogs with critical coronary stenoses., 2011; Circulation. Cardiovascular imaging. 4(6) 685-92. PMID: 21917783 | PMCID: PMC3587960

Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA, B-cell aortic homing and atheroprotection depend on Id3., 2011; Circulation research. 110(1) e1-12. PMID: 22034493 | PMCID: PMC3253259

Li D, Patel AR, Klibanov AL, Kramer CM, Ruiz M, Kang BY, Mehta JL, Beller GA, Glover DK, Meyer CH, Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT/CT and magnetic resonance., 2010; Circulation. Cardiovascular imaging. 3(4) 464-72. PMID: 20442371 | PMCID: PMC2955298

Patel RA, Glover DK, Broisat A, Kabul HK, Ruiz M, Goodman NC, Kramer CM, Meerdink DJ, Linden J, Beller GA, Reduction in myocardial infarct size at 48 hours after brief intravenous infusion of ATL-146e, a highly selective adenosine A2A receptor agonist., 2009; American journal of physiology. Heart and circulatory physiology. 297(2) H637-42. PMID: 19502555 | PMCID: PMC2724215

Glover DK, Ruiz M, Takehana K, Petruzella FD, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA, Cardioprotection by adenosine A2A agonists in a canine model of myocardial stunning produced by multiple episodes of transient ischemia., 2007; American journal of physiology. Heart and circulatory physiology. 292(6) H3164-71. PMID: 17308004