Steven Kenneth Malin


Primary Appointment

Assistant Professor, Kinesiology

Research Disciplines

Kinesiology, Physiology

Research Interests

Pathophysiology and Treatment of Type 2 Diabetes

Research Description

A primary mission of the Applied Metabolism & Physiology (AMP) Laboratory is âMetabolic Performanceâ. To that extent, a chief metabolic focus of our laboratory is to understand the pathophysiology of type 2 diabetes and identify novel strategies in which exercise minimizes insulin resistance for the prevention and treatment of type-2 diabetes across the lifespan. While exercise and low-fat diets combat obesity and reduce risk for chronic diseases, the optimal prescription remains unclear. Further complicating this matter is the fact that not all children and adults respond the same way to exercise, pharmacology, or bariatric surgery. Therefore, determining how to personalize exercise and diet modification for maximal metabolic fitness benefit in individuals at risk for chronic disease, and understanding the mechanisms behind such changes provides an ideal approach to promoting long-term metabolic health.
We are currently working on:
1. Tailoring exercise prescription to prevent the progression from prediabetes to type 2
diabetes in children and adults.
2. Examining how to incorporate physical activity and dietary modification to enhance the efficacy and durability of bariatric surgery on appetite and glucose regulation.
3. Determining how lifestyle modification and bariatric surgery interacts with pharmacology to regulate body weight and cardiometabolic health.
4. Gain mechanistic understanding into energy metabolism and endocrine-related inflammation by which lifestyle modification and bariatric surgery improves metabolic fitness.

Personal Statement

Dr. Steven K. Malin is an Assistant Professor in the Department of Kinesiology within the Curry School of Education and holds joint appointments in the Division of Endocrinology & Metabolism within the School of Medicine and the Robert M. Berne Cardiovascular Research Center. Dr. Malin has expertise in exercise metabolism and human nutrition. The primary focus of his clinical translational research is to prevent/treat obesity related type 2 diabetes. To accomplish this, Dr. Malin views exercise as a âdrugâ that when prescribed in an appropriate way (i.e. intensity/duration/frequency/mode) can optimize the prevention/treatment of cardiometabolic disease risk in individuals across the lifespan. His research focuses on the interaction of exercise with nutrient intake, pharmacology, and/or bariatric surgery to maximize improvements in insulin resistance, substrate oxidation, inflammation, and vascular function. Dr. Malin is the Director of the Applied Metabolism & Physiology (AMP) Laboratory and Co-Director of the Exercise Physiology Graduate Program in the Department of Kinesiology. He currently teaches undergraduate and graduate courses in Exercise Physiology and Energy Metabolism, and is an active member of the American College of Sports Medicine, American Diabetes Association, Obesity Society, and the American Physiological Society.

Selected Publications

Malin SK, Kashyap SR, Effects of various gastrointestinal procedures on β-cell function in obesity and type 2 diabetes., 2016; Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 12(6) 1213-9. PMID: 27568472

Malin SK, Kashyap SR, Type 2 Diabetes Treatment in the Patient with Obesity., 2016; Endocrinology and metabolism clinics of North America. 45(3) 553-64. PMID: 27519130

Malin SK, Rynders CA, Weltman JY, Jackson Roberts L, Barrett EJ, Weltman A, Endothelial function following glucose ingestion in adults with prediabetes: Role of exercise intensity., 2016; Obesity (Silver Spring, Md.). 24(7) 1515-21. PMID: 27221649 | PMCID: PMC4925188

Mehaffey JH, Mullen MG, Mehaffey RL, Turrentine FE, Malin SK, Kirby JL, Schirmer B, Hallowell PT, Type 2 diabetes remission following gastric bypass: does diarem stand the test of time?, 2016; Surgical endoscopy. () . PMID: 27177952

Malin SK, Rynders CA, Weltman JY, Barrett EJ, Weltman A, Exercise Intensity Modulates Glucose-Stimulated Insulin Secretion when Adjusted for Adipose, Liver and Skeletal Muscle Insulin Resistance., 2016; PloS one. 11(4) e0154063. PMID: 27111219 | PMCID: PMC4844153

Malin SK, Liu Z, Barrett EJ, Weltman A, Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism., 2016; Reviews in endocrine & metabolic disorders. 17(1) 81-90. PMID: 27106830

Malin SK, Braun B, Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk., 2015; Exercise and sport sciences reviews. 44(1) 4-11. PMID: 26583801

Malin SK, Kashyap SR, Differences in Weight Loss and Gut Hormones: Rouen-Y Gastric Bypass and Sleeve Gastrectomy Surgery., 2015; Current obesity reports. 4(2) 279-86. PMID: 26627222

Rynders CA, Weltman JY, Malin SK, Jiang B, Breton M, Barrett EJ, Weltman A, Comparing Simple Insulin Sensitivity Indices to the Oral Minimal Model Postexercise., 2015; Medicine and science in sports and exercise. () . PMID: 26154337