Dan Theodorescu

Primary Appointment

Professor Emeritus, Urology

Selected Publications

Thomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D, Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer., 2011; Cancer Res. 71(3) 832-41.

Pollard C, Smith SC, Theodorescu D, Molecular genesis of non-muscle-invasive urothelial carcinoma (NMIUC)., 2010; Expert Rev Mol Med. 12(0) e10.

Lee JK, Coutant C, Kim YC, Qi Y, Theodorescu D, Symmans WF, Baggerly K, Rouzier R, Pusztai L, Prospective comparison of clinical and genomic multivariate predictors of response to neoadjuvant chemotherapy in breast cancer., 2010; Clin Cancer Res. 16(2) 711-8.

Smith SC, Baras AS, Lee JK, Theodorescu D, The COXEN principle: translating signatures of in vitro chemosensitivity into tools for clinical outcome prediction and drug discovery in cancer., 2010; Cancer Res. 70(5) 1753-8.

Cathro HP, Smolkin ME, Theodorescu D, Jo VY, Ferrone S, Frierson Jr, Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas., 2010; Cancer Immunol Immunother. 0(59) 3.0.

Krupski TL, Stukenborg GJ, Moon K, Theodorescu D, The relationship of palliative transurethral resection of the prostate with disease progression in patients with prostate cancer., 2010; BJU Int. 0(0) null.

Harding MA, Theodorescu D, RhoGDI signaling provides targets for cancer therapy., 2010; Eur J Cancer. 46(7) 1252-9.

Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D, Phosphorylation of RalB Is Important for Bladder Cancer Cell Growth and Metastasis., 2010; Cancer Res. 70(21) 8760-9.

Krupski TL, Stukenborg GJ, Moon K, Theodorescu D, The relationship of palliative transurethral resection of the prostate with disease progression in patients with prostate cancer., 2010; BJU Int. 106(10) 1477-83.

Wu Y, Moissoglu K, Wang H, Wang X, Frierson HF, Schwartz MA, Theodorescu D, Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function., 2009; Proc Natl Acad Sci U S A. 106(14) 5807-12.

Wu Z, Cho H, Hampton GM, Theodorescu D, Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis., 2009; Neoplasia. 11(1) 66-76.

Williams PD, Lee JK, Theodorescu D, Genomancy: predicting tumour response to cancer therapy based on the oracle of genetics., 2009; Curr Oncol. 16(1) 56-8.

Smith SC, Nicholson B, Nitz M, Frierson Jr, Smolkin M, Hampton G, El-Rifai W, Theodorescu D, Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination., 2009; Am J Pathol. 174(2) 371-9.

Smith SC, Theodorescu D, The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target., 2009; Urol Oncol. 27(1) 42-7.

Smith SC, Theodorescu D, Learning therapeutic lessons from metastasis suppressor proteins., 2009; Nat Rev Cancer. 9(4) 253-64.

Moissoglu K, McRoberts KS, Meier JA, Theodorescu D, Schwartz MA, Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases., 2009; Cancer Res. 69(7) 2838-44.

Overdevest JB, Theodorescu D, Lee JK, Utilizing the molecular gateway: the path to personalized cancer management., 2009; Clin Chem. 55(4) 684-97.

Ehdaie B, Stukenborg GJ, Theodorescu D, Renal transplant recipients and patients with end stage renal disease present with more advanced bladder cancer., 2009; J Urol. 182(4) 1482-7.

Slack-Davis JK, Hershey ED, Theodorescu D, Frierson HF, Parsons JT, Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model., 2009; Mol Cancer Ther. 8(8) 2470-7.

Said N, Frierson Jr, Chernauskas D, Conaway M, Motamed K, Theodorescu D, The role of SPARC in the TRAMP model of prostate carcinogenesis and progression., 2009; Oncogene. 28(39) 3487-98.

Said N, Frierson Jr, Chernauskas D, Conaway M, Motamed K, Theodorescu D, The role of SPARC in the TRAMP model of prostate carcinogenesis and progression., 2009; Oncogene. 0(28) 39.0.

Havaleshko DM, Smith SC, Cho H, Cheon S, Owens CR, Lee JK, Liotta LA, Espina V, Wulfkuhle JD, Petricoin EF, Theodorescu D, Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer., 2009; Neoplasia. 11(11) 1185-93.

Williams PD, Cheon S, Havaleshko DM, Jeong H, Cheng F, Theodorescu D, Lee JK, Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing systemic therapy., 2009; Cancer Res. 69(21) 8302-9.

Pollard C, Nitz M, Baras A, Williams P, Moskaluk C, Theodorescu D, Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy., 2009; Am J Pathol. 175(5) 1824-30.

Said N, Theodorescu D, Pathways of metastasis suppression in bladder cancer., 2009; Cancer Metastasis Rev. 28(3) 327-33.

Smalley DM, Sheman NE, Nelson K, Theodorescu D, Isolation and identification of potential urinary microparticle biomarkers of bladder cancer., 2008; J Proteome Res. 7(5) 2088-96.

Wu Y, Siadaty MS, Berens ME, Hampton GM, Theodorescu D, Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration., 2008; Oncogene. 27(52) 6679-89.

Schwartz MA, McRoberts K, Coyner M, Andarawewa KL, Frierson Jr, Sanders JM, Swenson S, Markland F, Conaway MR, Theodorescu D, Integrin agonists as adjuvants in chemotherapy for melanoma., 2008; Clin Cancer Res. 14(19) 6193-7.

Jones RA, Taylor AG, Bourguignon C, Steeves R, Fraser G, Lippert M, Theodorescu D, Mathews H, Kilbridge KL, Family interactions among African American prostate cancer survivors., 2008; Fam Community Health. 31(3) 213-20.

Williams PD, Lee JK, Theodorescu D, Molecular credentialing of rodent bladder carcinogenesis models., 2008; Neoplasia. 10(8) 838-46.

Ehdaie B, Theodorescu D, Predicting tumor outcomes in urothelial bladder carcinoma: turning pathways into clinical biomarkers of prognosis., 2008; Expert Rev Anticancer Ther. 8(7) 1103-10.

Wu Z, Gioeli D, Conaway M, Weber MJ, Theodorescu D, Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors., 2008; Prostate. 68(9) 935-44.

Theodorescu D, Schiffer E, Bauer HW, Douwes F, Eichhorn F, Polley R, Schmidt T, Schöfer W, Zürbig P, Good DM, Coon JJ, Mischak H, Discovery and validation of urinary biomarkers for prostate cancer., 2008; Proteomics Clin Appl. 2(4) 556-570.

Ehdaie B, Theodorescu D, Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis., 2008; Indian J Urol. 24(1) 61-7.

Wu Y, McRoberts K, Berr SS, Frierson Jr, Conaway M, Theodorescu D, Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia., 2007; Oncogene. 26(5) 765-73.

Smith SC, Oxford G, Baras AS, Owens C, Havaleshko D, Brautigan DL, Safo MK, Theodorescu D, Expression of ral GTPases, their effectors, and activators in human bladder cancer., 2007; Clin Cancer Res. 13(13) 3803-13.

Herlevsen M, Oxford G, Ptak C, Shabanowitz J, Hunt DF, Conaway M, Theodorescu D, A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer., 2007; Biochem Biophys Res Commun. 352(2) 549-55.

Havaleshko DM, Cho H, Conaway M, Owens CR, Hampton G, Lee JK, Theodorescu D, Prediction of drug combination chemosensitivity in human bladder cancer., 2007; Mol Cancer Ther. 6(2) 578-86.

Flury SC, Galgano MT, Mills SE, Smolkin ME, Theodorescu D, Atypical small acinar proliferation: biopsy artefact or distinct pathological entity?, 2007; BJU Int. 99(4) 780-5.

Ehdaie B, Theodorescu D, Organ-sparing techniques for penile cancer: quo vadis?, 2007; Nat Clin Pract Urol. 4(4) 182-3.

Herlevsen M, Oxford G, Owens CR, Conaway M, Theodorescu D, Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes., 2007; Mol Cancer Ther. 6(6) 1804-13.

Jones RA, Taylor AG, Bourguignon C, Steeves R, Fraser G, Lippert M, Theodorescu D, Mathews H, Kilbridge KL, Complementary and alternative medicine modality use and beliefs among African American prostate cancer survivors., 2007; Oncol Nurs Forum. 34(2) 359-64.

Wu Z, McRoberts KS, Theodorescu D, The role of PTEN in prostate cancer cell tropism to the bone micro-environment., 2007; Carcinogenesis. 28(7) 1393-400.

Lee JK, Havaleshko DM, Cho H, Weinstein JN, Kaldjian EP, Karpovich J, Grimshaw A, Theodorescu D, A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery., 2007; Proc Natl Acad Sci U S A. 104(32) 13086-91.

Theodorescu D, Mischak H, Mass spectrometry based proteomics in urine biomarker discovery., 2007; World J Urol. 25(5) 435-43.

Bigler D, Gioeli D, Conaway MR, Weber MJ, Theodorescu D, Rap2 regulates androgen sensitivity in human prostate cancer cells., 2007; Prostate. 67(14) 1590-9.

Harding MA, Theodorescu D, RhoGDI2: a new metastasis suppressor gene: discovery and clinical translation., 2007; Urol Oncol. 25(5) 401-6.

Herlevsen MC, Theodorescu D, Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76)., 2007; Biochem Biophys Res Commun. 362(1) 56-62.

Oxford G, Smith SC, Hampton G, Theodorescu D, Expression profiling of Ral-depleted bladder cancer cells identifies RREB-1 as a novel transcriptional Ral effector., 2007; Oncogene. 26(50) 7143-52.

Lee JK, Havaleshko DM, Cho H, Weinstein JN, Kaldjian EP, Karpovich J, Grimshaw A, Theodorescu D, A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery., 2007; Proc Natl Acad Sci U S A. 104(32) 13086-91.

Moon K, Stukenborg GJ, Keim J, Theodorescu D, Cancer incidence after localized therapy for prostate cancer., 2006; Cancer. 107(5) 991-8.

Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF, Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis., 2006; Lancet Oncol. 7(3) 230-40.

Keim JL, Theodorescu D, Robot-assisted radical cystectomy in the management of bladder cancer., 2006; ScientificWorldJournal. 6(0) 2560-5.

Wu Z, Conaway M, Gioeli D, Weber MJ, Theodorescu D, Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells., 2006; Prostate. 66(10) 1114-23.

Copp HL, Chin JL, Conaway M, Theodorescu D, Prospective evaluation of the prognostic relevance of molecular staging for urothelial carcinoma., 2006; Cancer. 107(1) 60-6.

Rhee JJ, Lebeau S, Smolkin M, Theodorescu D, Radical cystectomy with ileal conduit diversion: early prospective evaluation of the impact of robotic assistance., 2006; BJU Int. 98(5) 1059-63.

Moon K, Theodorescu D, Does saturation biopsy improve prostate cancer detection?, 2006; Nat Clin Pract Urol. 3(9) 468-9.

Thomas CY, Theodorescu D, Collaboration of RON and epidermal growth factor receptor in human bladder carcinogenesis., 2006; J Urol. 0(176) 5.0.

Thomas CY, Theodorescu D, Molecular markers of prognosis and novel therapeutic strategies for urothelial cell carcinomas., 2006; World J Urol. 24(5) 565-78.

Fletcher SG, Mills SE, Smolkin ME, Theodorescu D, Case-matched comparison of contemporary radiation therapy to surgery in patients with locally advanced prostate cancer., 2006; Int J Radiat Oncol Biol Phys. 66(4) 1092-9.

Smith SC, Oxford G, Wu Z, Nitz MD, Conaway M, Frierson HF, Hampton G, Theodorescu D, The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer., 2006; Cancer Res. 66(4) 1917-22.

Wu Z, Siadaty MS, Riddick G, Frierson Jr, Lee JK, Golden W, Knuutila S, Hampton GM, El-Rifai W, Theodorescu D, A novel method for gene expression mapping of metastatic competence in human bladder cancer., 2006; Neoplasia. 8(3) 181-9.

Wu Z, Owens C, Chandra N, Popovic K, Conaway M, Theodorescu D, RalBP1 is necessary for metastasis of human cancer cell lines., ; Neoplasia. 12(12) 1003-12.

Smith SC, Havaleshko DM, Moon K, Baras AS, Lee J, Bekiranov S, Burke DJ, Theodorescu D, Use of yeast chemigenomics and COXEN informatics in preclinical evaluation of anticancer agents., ; Neoplasia. 13(1) 72-80.

Nitz MD, Harding MA, Theodorescu D, Invasion and metastasis models for studying RhoGDI2 in bladder cancer., ; Methods Enzymol. 439(0) 219-33.