Craig S. Nunemaker
- Email: nunemake@ohio.edu
- Phone: 434-924-0229
- Website: http://www.medicine.virginia.edu/clinical/departments/medicine/divisions/endocrine/research/labs/nunemaker/profile
Primary Appointment
Associate Professor, Ohio University, Unaffiliated
Education
- BS, Physics, College of William and Mary
- PhD, Neuroscience, University of Virginia
Research Interests
Pancreatic islet/beta-cell physiology and diabetes
Research Description
We are also developing techniques to assess and improve islet health and function. One project, funded by the Mouse Metabolic Phenotyping Center, involves pre-labeling one set of islets with an inert fluorescent dye to allow simultaneous comparisons of labeled and unlabeled islets under identical conditions. This approach will provide valuable and novel information about dynamic changes in islet metabolic rates, calcium handling, and secretion in response to glucose or other stimuli in order to detect very precise deficiencies or enhancements in islet function. We will utilize this technique to identify precursors of islet dysfunction and to assess potential therapies for diabetes at the islet level.
Personal Statement
source(s) of dysfunctional calcium handling including endoplasmic reticulum stress, mitochondrial disruption, and ion-channel dysfunction using a combination of physiological and molecular approaches. By identifying the physiological impact of cytokines at very low doses, we hope to identify early and reversible steps in islet dysfunction.
We are also developing techniques to assess and improve islet health and function. One project, funded by the Mouse Metabolic Phenotyping Center, involves pre-labeling one set of islets with an inert fluorescent dye to allow simultaneous comparisons of labeled and unlabeled islets under identical conditions. This approach will provide valuable and novel information about dynamic changes in islet metabolic rates, calcium handling, and secretion in response to glucose or other stimuli in order to detect very precise deficiencies or enhancements in islet function. We will utilize this technique to identify precursors of islet dysfunction and to assess potential therapies for diabetes at the islet level.
Selected Publications
Nunemaker CS, Chung HG, Verrilli GM, Corbin KL, Upadhye A, Sharma PR, Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function., 2014; The Journal of endocrinology. 222(2) 267-76. PMID: 24928936 | PMCID: PMC4135511
O'Neill CM, Lu C, Corbin KL, Sharma PR, Dula SB, Carter JD, Ramadan JW, Xin W, Lee JK, Nunemaker CS, Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice., 2013; Endocrinology. 154(9) 3077-88. PMID: 23836031 | PMCID: PMC3749476
Antkowiak PF, Stevens BK, Nunemaker CS, McDuffie M, Epstein FH, Manganese-enhanced magnetic resonance imaging detects declining pancreatic β-cell mass in a cyclophosphamide-accelerated mouse model of type 1 diabetes., 2012; Diabetes. 62(1) 44-8. PMID: 22933107 | PMCID: PMC3526033
Corbin KL, Hall TE, Haile R, Nunemaker CS, A novel fluorescence imaging approach for comparative measurements of pancreatic islet function in vitro., 2011; Islets. 3(1) 14-20. PMID: 21266850 | PMCID: PMC3060435
Cole BK, Keller SR, Wu R, Carter JD, Nadler JL, Nunemaker CS, Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice., 2010; Hypertension. 55(3) 715-21. PMID: 20100990 | PMCID: PMC2836256
Nunemaker CS, Dishinger JF, Dula SB, Wu R, Merrins MJ, Reid KR, Sherman A, Kennedy RT, Satin LS, Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets., 2009; PloS one. 4(12) e8428. PMID: 20037650 | PMCID: PMC2793028
Jahanshahi P, Wu R, Carter JD, Nunemaker CS, Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets., 2008; Endocrinology. 150(2) 607-15. PMID: 18818288 | PMCID: PMC2646533