Jae K. Lee

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Primary Appointment

Associate Professor, Public Health Sciences

Research Interests

Genomic expression-based personalized chemotherapeutic response prediction; Integrative pathway modeling on atherosclerosis and cancer immunogenicity; Discovery of chemosensitivity biomarkers and novel chemotherapeutic compounds.

Research Description

Dr. Lee has extensive experience in statistical research in molecular genetics and bioinformatics. He has worked on statistical approaches to genetic population inference, DNA structure analysis, high-throughput gene chip technologies, and linkage association study for human genetic diseases. He has also applied and developed computational statistical techniques to attack various challenging problems in molecular biology and cancer genetics. This includes anticancer gene-drug discovery on high throughput gene expression data and linkage association study for identifying quantitative trait loci of pedigree data. Dr. Lee's current interest is in the analysis of microarray gene expression data. Dr. Lee serves as Director of the UVA GeneChip/Microarray Bioinformatics Core (GMB), which provides statistical and bioinformatics support for UVA researchers' microarray studies.

Personal Statement

Dr. Lee has extensive experience in statistical research in molecular genetics and bioinformatics. He has worked on statistical approaches to genetic population inference, DNA structure analysis, high-throughput gene chip technologies, and linkage association study for human genetic diseases. He has also applied and developed computational statistical techniques to attack various challenging problems in molecular biology and cancer genetics. This includes anticancer gene-drug discovery on high throughput gene expression data and linkage association study for identifying quantitative trait loci of pedigree data. Dr. Lee's current interest is in the analysis of microarray gene expression data. Dr. Lee serves as Director of the UVA GeneChip/Microarray Bioinformatics Core (GMB), which provides statistical and bioinformatics support for the UVA researchers' microarray studies.

Selected Publications

Cheng F, Keeley EC, Lee JK, Molecular prediction for atherogenic risks across different cell types of leukocytes., 2012; BMC medical genomics. 5() 2. PMID: 22244445 | PMCID: PMC3271975

Williams PD, Owens CR, Dziegielewski J, Moskaluk CA, Read PW, Larner JM, Story MD, Brock WA, Amundson SA, Lee JK, Theodorescu D, Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy., 2012; Neoplasia (New York, N.Y.). 13(12) 1122-31. PMID: 22241958 | PMCID: PMC3257187

Sharma R, Sharma PR, Kim YC, Leitinger N, Lee JK, Fu SM, Ju ST, IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation., 2011; J Immunol. 186(2) 1268-78. PMID: | PMCID: PMC3136806

Smith SC, Havaleshko DM, Moon K, Baras AS, Lee J, Bekiranov S, Burke DJ, Theodorescu D, Use of yeast chemigenomics and COXEN informatics in preclinical evaluation of anticancer agents., 2011; Neoplasia (New York, N.Y.). 13(1) 72-80. PMID: 21253455 | PMCID: PMC3023847

Cheng F, Theodorescu D, Schulman IG, Lee JK, In vitro transcriptomic prediction of hepatotoxicity for early drug discovery., 2011; Journal of theoretical biology. 290() 27-36. PMID: 21884709 | PMCID: PMC3386613

Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK, Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice., 2011; The Journal of clinical investigation. 122(1) 70-9. PMID: 22201681 | PMCID: PMC3248279

Nagji AS, Cho SH, Liu Y, Lee JK, Jones DR, Multigene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer., 2010; Mol Cancer Ther. 9(10) 2834-43. PMID: | PMCID: PMC2953585

Smith SC, Baras AS, Lee JK, Theodorescu D, The COXEN principle: translating signatures of in vitro chemosensitivity into tools for clinical outcome prediction and drug discovery in cancer., 2010; Cancer Res. 70(5) 1753-8. PMID: | PMCID: PMC2831138

Lee JK, Coutant C, Kim YC, Qi Y, Theodorescu D, Symmans WF, Baggerly K, Rouzier R, Pusztai L, Prospective comparison of clinical and genomic multivariate predictors of response to neoadjuvant chemotherapy in breast cancer., 2010; Clin Cancer Res. 16(2) 711-8. PMID: | PMCID: PMC2807997

Williams PD, Cheon S, Havaleshko DM, Jeong H, Cheng F, Theodorescu D, Lee JK, Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing systemic therapy., 2009; Cancer Res. 69(21) 8302-9. PMID: | PMCID: PMC2784269

Kefas B, Comeau L, Floyd DH, Seleverstov O, Godlewski J, Schmittgen T, Jiang J, diPierro CG, Li Y, Chiocca EA, Lee J, Fine H, Abounader R, Lawler S, Purow B, The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors., 2009; J Neurosci. 29(48) 15161-8. PMID: | PMCID: PMC2823067

Havaleshko DM, Smith SC, Cho H, Cheon S, Owens CR, Lee JK, Liotta LA, Espina V, Wulfkuhle JD, Petricoin EF, Theodorescu D, Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer., 2009; Neoplasia. 11(11) 1185-93. PMID: | PMCID: PMC2767220

Kim Y, Bekiranov S, Lee JK, Park T, Double error shrinkage method for identifying protein binding sites observed by tiling arrays with limited replication., 2009; Bioinformatics. 25(19) 2486-91. PMID: | PMCID: PMC2800349

Williams PD, Lee JK, Theodorescu D, Genomancy: predicting tumour response to cancer therapy based on the oracle of genetics., 2009; Curr Oncol. 16(1) 56-8. PMID: | PMCID: PMC2644622

Nagelin MH, Srinivasan S, Lee J, Nadler JL, Hedrick CC, 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1., 2008; Arterioscler Thromb Vasc Biol. 28(10) 1811-9. PMID: | PMCID: PMC2749732

Williams PD, Lee JK, Theodorescu D, Molecular credentialing of rodent bladder carcinogenesis models., 2008; Neoplasia. 10(8) 838-46. PMID: | PMCID: PMC2481571

Lee JM, Gianchandani EP, Eddy JA, Papin JA, Dynamic analysis of integrated signaling, metabolic, and regulatory networks., 2008; PLoS Comput Biol. 4(5) e1000086. PMID: | PMCID: PMC2377155

Lee JK, Williams PD, Cheon S, Data mining in genomics., 2008; Clin Lab Med. 28(1) 145-66, viii. PMID: | PMCID: PMC2253491

Aiyar SE, Cho H, Lee J, Li R, Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells., 2007; Int J Biol Sci. 3(7) 486-92. PMID: | PMCID: PMC2096739

Lee JK, Havaleshko DM, Cho H, Weinstein JN, Kaldjian EP, Karpovich J, Grimshaw A, Theodorescu D, A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery., 2007; Proc Natl Acad Sci U S A. 104(32) 13086-91. PMID: | PMCID: PMC1941805

Lee JK, Havaleshko DM, Cho H, Weinstein JN, Kaldjian EP, Karpovich J, Grimshaw A, Theodorescu D, A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery., 2007; Proc Natl Acad Sci U S A. 104(32) 13086-91. PMID: | PMCID: PMC1941805

Wu Z, Siadaty MS, Riddick G, Frierson Jr, Lee JK, Golden W, Knuutila S, Hampton GM, El-Rifai W, Theodorescu D, A novel method for gene expression mapping of metastatic competence in human bladder cancer., 2006; Neoplasia. 8(3) 181-9. PMID: | PMCID: PMC1578518

Smith SC, Havaleshko DM, Moon K, Baras AS, Lee J, Bekiranov S, Burke DJ, Theodorescu D, Use of yeast chemigenomics and COXEN informatics in preclinical evaluation of anticancer agents., ; Neoplasia. 13(1) 72-80. PMID: | PMCID: PMC3023847

Park T, Kim Y, Bekiranov S, Lee JK, Error-pooling-based statistical methods for identifying novel temporal replication profiles of human chromosomes observed by DNA tiling arrays., ; Nucleic Acids Res. 35(9) e69. PMID: | PMCID: PMC1888820