Mary J. Laughlin

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Primary Appointment

Professor, Unaffiliated

Research Interests

Clinical protocols related to the application of unrelated Umbilical Cord Blood transplantation; Cancer; Immunology; Stem Cells; Cardiovascular; Proteomics

Personal Statement


OUR LABORATORY GROUP FOCUSES ON STEM CELL AND IMMUNOLOGY STUDIES IN UMBILICAL CORD BLOOD, WHICH DUE TO ITS UNIQUE PROLIFERATIVE AND IMMUNOLOGIC CHARACTERISTICS, RENDER THIS AN IDEAL STEM CELL SOURCE FOR CLINICAL APPLICATIONS.
TO MORE FULLY UNDERSTAND THE STEM CELL BIOLOGY AND IMMUNOLOGY UNDERLYING ALLOGENEIC TRANSPLANTATION WITH UNRELATED UCB, WE CURRENTLY FOLLOW SEVERAL LINES OF INQUIRY IN OUR LABORATORY:

  1. REGULATION OF CELL SIGNALING IN UCB GRAFT CD4 T LYMPHOCYTES CONTROLLING CELL CYCLE AND CYTOKINE PRODUCTION.
  2. ANALYSES OF MESENCHYMAL STEM CELLS AND UCB HEMATOPOIETIC STEM CELLS DURING IN VITRO CULTURE EXPANSION.
  3. REGULATION OF EARLY EVENTS IN UCB STEM CELL DIFFERENTIATION COMPARING HEMATOPOIESIS.
  4. NEOVASCULARIZATION MEDIATED BY UCB-DERIVED HEMATOPOIETIC STEM CELLS.
  5. CXCR4-SDF-1 INTERACTIONS AND STRESS RESPONSE BIOACTIVE LIPIDS AND AMINES IMPACTING DONOR STEM CELL AND T LYMPHOCYTE TRAFFICKING AFTER UCB TRANSPLANTATION.

Selected Publications

Brunstein CG, Eapen M, Ahn KW, Appelbaum FR, Ballen KK, Champlin RE, Cutler C, Kan F, Laughlin MJ, Soiffer RJ, Weisdorf DJ, Woolfrey A, Wagner JE, Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on outcomes., 2012; Blood. 119(23) 5591-8. PMID: 22496153 | PMCID: PMC3369691

Wu W, Kim CH, Liu R, Kucia M, Marlicz W, Greco N, Ratajczak J, Laughlin MJ, Ratajczak MZ, The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation., 2011; Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 26(4) 736-45. PMID: 21931324 | PMCID: PMC3244577

Ratajczak MZ, Kim CH, Abdel-Latif A, Schneider G, Kucia M, Morris AJ, Laughlin MJ, Ratajczak J, A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients., 2011; Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 26(1) 63-72. PMID: 21886175

Passweg JR, Zhang MJ, Rocha V, Kan F, Champlin RE, Isola LM, Gee AP, Gibson J, Laughlin MJ, Lazarus HM, Loren A, Marks DI, Gratwohl A, Eapen M, Donor characteristics affecting graft failure, graft-versus-host disease, and survival after unrelated donor transplantation with reduced-intensity conditioning for hematologic malignancies., 2011; Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(12) 1869-73. PMID: 21771571 | PMCID: PMC3217167

Ratajczak J, Zuba-Surma E, Klich I, Liu R, Wysoczynski M, Greco N, Kucia M, Laughlin MJ, Ratajczak MZ, Hematopoietic differentiation of umbilical cord blood-derived very small embryonic/epiblast-like stem cells., 2011; Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 25(8) 1278-85. PMID: 21483440 | PMCID: PMC3135663

Lazarus HM, Sommers SR, Arfons LM, Fu P, Ataergin SA, Kaye NM, Liu F, Kindwall-Keller TL, Cooper BW, Laughlin MJ, Creger RJ, Barr PM, Gerson SL, Kaplan D, Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts., 2011; Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(7) 970-8. PMID: 21440080

Adler DS, Lazarus H, Nair R, Goldberg JL, Greco NJ, Lassar T, Laughlin MJ, Das H, Pompili VJ, Safety and efficacy of bone marrow-derived autologous CD133+ stem cell therapy., 2011; Frontiers in bioscience (Elite edition). 3() 506-14. PMID: 21196330 | PMCID: PMC3285247

Laughlin M, Kurtzberg J, McMannis J, Petz L, Eighth Annual International Umbilical Cord Blood Transplantation Symposium, San Francisco, California, June 3-5, 2010., 2010; Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(2) 176-89. PMID: 20951820