Patrice G. Guyenet

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  • Phone: 434-924-9974
  • Fax: 434-982-3878

Primary Appointment

Professor Emeritus, Pharmacology

Education

  • BS, Physiology & Biochemistry, Ecole Normale Superieure
  • PhD, Neurochemistry, University of Paris
  • Postdoc, Neuropharmacology, Yale University

Research Disciplines

Cardiovascular Biology, Molecular Pharmacology, Neuroscience

Personal Statement

My research is a branch of Integrative Neuroscience, a discipline that seeks to understand how the brain processes specific types of information. The laboratory studies how the mammalian brain regulates respiration and blood pressure, two physiological processes that are dysfunctional in very common diseases (hypertension, obesity, apneic syndromes, heart failure, etc.). The work consists of identifying relevant neuronal networks in rodents using electrophysiologic and neuroanatomic methods. The main focus is on a region of the brainstem that provides the chemical drive to breathe and contains the neurons that maintain blood pressure.

Selected Publications

2021

Simonson, T. S., Baker, T. L., Banzett, R. B., Bishop, T., Dempsey, J. A., Feldman, J. L., . . . Malhotra, A. (2021). Silent hypoxaemia in COVID-19 patients.. The Journal of physiology, 599(4), 1057-1065. doi:10.1113/jp280769

Shi, Y., Stornetta, D. S., Reklow, R. J., Sahu, A., Wabara, Y., Nguyen, A., . . . Bayliss, D. A. (2021). A brainstem peptide system activated at birth protects postnatal breathing. NATURE, 589(7842), 426-+. doi:10.1038/s41586-020-2991-4

2020

Souza, G. M. P. R., Stornetta, R. L., Stornetta, D. S., Abbott, S. B. G., & Guyenet, P. G. (2020). Differential Contribution of the Retrotrapezoid Nucleus and C1 Neurons to Active Expiration and Arousal in Rats. JOURNAL OF NEUROSCIENCE, 40(45), 8683-8697. doi:10.1523/JNEUROSCI.1006-20.2020

Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., & Brooks, V. L. (2020). Neuronal Networks in Hypertension Recent Advances. HYPERTENSION, 76(2), 300-311. doi:10.1161/HYPERTENSIONAHA.120.14521

2019

Souza, G. M. P. R., Stornetta, R. L., Stornetta, D. S., Abbott, S. B. G., & Guyenet, P. G. (2019). Contribution of the Retrotrapezoid Nucleus and Carotid Bodies to Hypercapnia- and Hypoxia-induced Arousal from Sleep. JOURNAL OF NEUROSCIENCE, 39(49), 9725-9737. doi:10.1523/JNEUROSCI.1268-19.2019

Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., Shi, Y., & Bayliss, D. A. (2019). The Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity. TRENDS IN NEUROSCIENCES, 42(11), 807-824. doi:10.1016/j.tins.2019.09.002

Guyenet, P. G. (2019). Sodium Is Detected by the OVLT to Regulate Sympathetic Tone. NEURON, 101(1), 3-5. doi:10.1016/j.neuron.2018.12.015

2018

Guyenet, P. G., Stornetta, R. L., Holloway, B. B., Souza, G. M. P. R., & Abbott, S. B. G. (2018). Rostral Ventrolateral Medulla and Hypertension. HYPERTENSION, 72(3), 559-566. doi:10.1161/HYPERTENSIONAHA.118.10921

Souza, G. M. P. R., Kanbar, R., Stornetta, D. S., Abbott, S. B. G., Stornetta, R. L., & Guyenet, P. G. (2018). Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats. JOURNAL OF PHYSIOLOGY-LONDON, 596(13), 2521-2545. doi:10.1113/JP275866

Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Kanbar, R., Shi, Y., Holloway, B. B., . . . Wenker, I. C. (2018). Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 596(15), 3029-3042. doi:10.1113/JP274357

Stornetta, R. L., & Guyenet, P. G. (2018). C1 neurons: a nodal point for stress?. EXPERIMENTAL PHYSIOLOGY, 103(3), 332-336. doi:10.1113/EP086435

2017

Valentino, R. J., Guyenet, P., Hou, X. H., & Herman, M. (2017). Central Network Dynamics Regulating Visceral and Humoral Functions. JOURNAL OF NEUROSCIENCE, 37(45), 10848-10854. doi:10.1523/JNEUROSCI.1833-17.2017

Shi, Y., Stornetta, R. L., Stornetta, D. S., Onengut-Gumuscu, S., Farber, E. A., Turner, S. D., . . . Bayliss, D. A. (2017). Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus. JOURNAL OF NEUROSCIENCE, 37(48), 11744-11757. doi:10.1523/JNEUROSCI.2055-17.2017

Wenker, I. C., Abe, C., Viar, K. E., Stornetta, D. S., Stornetta, R. L., & Guyenet, P. G. (2017). Blood Pressure Regulation by the Rostral Ventrolateral Medulla in Conscious Rats: Effects of Hypoxia, Hypercapnia, Baroreceptor Denervation, and Anesthesia. JOURNAL OF NEUROSCIENCE, 37(17), 4565-4583. doi:10.1523/JNEUROSCI.3922-16.2017

Abe, C., Inoue, T., Inglis, M. A., Viar, K. E., Huang, L., Ye, H., . . . Guyenet, P. G. (2017). C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. NATURE NEUROSCIENCE, 20(5), 700-+. doi:10.1038/nn.4526

Guyenet, P. G. (2017). Putative Mechanism of Salt-Dependent Neurogenic Hypertension: Cell-Autonomous Activation of Organum Vasculosum Laminae Terminalis Neurons by Hypernatremia. HYPERTENSION, 69(1), 20-22. doi:10.1161/HYPERTENSIONAHA.116.08470

2016

Kanbar, R., Stornetta, R. L., & Guyenet, P. G. (2016). Sciatic nerve stimulation activates the retrotrapezoid nucleus in anesthetized rats. JOURNAL OF NEUROPHYSIOLOGY, 116(5), 2081-2092. doi:10.1152/jn.00543.2016

Shi, Y., Abe, C., Holloway, B. B., Shu, S., Kumar, N. N., Weaver, J. L., . . . Bayliss, D. A. (2016). Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing. JOURNAL OF NEUROSCIENCE, 36(31), 8174-8187. doi:10.1523/JNEUROSCI.1096-16.2016

Inoue, T., Abe, C., Sung, S. -S. J., Moscalu, S., Jankowski, J., Huang, L., . . . Okusa, M. D. (2016). Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. JOURNAL OF CLINICAL INVESTIGATION, 126(5), 1939-1952. doi:10.1172/JCI83658

Basting, T. M., Abe, C., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2016). Is plasticity within the retrotrapezoid nucleus responsible for the recovery of the PCO2 set-point after carotid body denervation in rats?. JOURNAL OF PHYSIOLOGY-LONDON, 594(12), 3371-3390. doi:10.1113/JP272046

Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Ludwig, M. -G., Kumar, N. N., Shi, Y., . . . Wenker, I. C. (2016). Proton detection and breathing regulation by the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 594(6), 1529-1551. doi:10.1113/JP271480

Stornetta, R. L., Inglis, M. A., Viar, K. E., & Guyenet, P. G. (2016). Afferent and efferent connections of C1 cells with spinal cord or hypothalamic projections in mice. BRAIN STRUCTURE & FUNCTION, 221(8), 4027-4044. doi:10.1007/s00429-015-1143-3

2015

Guyenet, P. G., & Bayliss, D. A. (2015). Neural Control of Breathing and CO2 Homeostasis. NEURON, 87(5), 946-961. doi:10.1016/j.neuron.2015.08.001

Burke, P. G. R., Kanbar, R., Basting, T. M., Hodges, W. M., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). State-dependent control of breathing by the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 593(13), 2909-2926. doi:10.1113/JP270053

Holloway, B. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice. EUROPEAN JOURNAL OF NEUROSCIENCE, 42(6), 2271-2282. doi:10.1111/ejn.12996

Kumar, N. N., Velic, A., Soliz, J., Shi, Y., Li, K., Wang, S., . . . Bayliss, D. A. (2015). Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. SCIENCE, 348(6240), 1255-1260. doi:10.1126/science.aaa0922

Burke, P. G. R., Kanbar, R., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. JOURNAL OF APPLIED PHYSIOLOGY, 118(12), 1491-1501. doi:10.1152/japplphysiol.00164.2015

Basting, T. M., Burke, P. G. R., Kanbar, R., Viar, K. E., Stornetta, D. S., Stornetta, R. L., & Guyenet, P. G. (2015). Hypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via Alkalosis. JOURNAL OF NEUROSCIENCE, 35(2), 527-543. doi:10.1523/JNEUROSCI.2923-14.2015

Bayliss, D. A., Barhanin, J., Gestreau, C., & Guyenet, P. G. (2015). The role of pH-sensitive TASK channels in central respiratory chemoreception. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 467(5), 917-929. doi:10.1007/s00424-014-1633-9

2014

Bochorishvili, G., Nguyen, T., Coates, M. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2014). The Orexinergic Neurons Receive Synaptic Input From C1 Cells in Rats. JOURNAL OF COMPARATIVE NEUROLOGY, 522(17), 3834-3846. doi:10.1002/cne.23643

Bochorishvili, G., Thanh, N., Coates, M. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2014). The Orexinergic Neurons Receive Synaptic Input From C1 Cells in Rats. JOURNAL OF COMPARATIVE NEUROLOGY, 522(17), 3834-3846. doi:10.1002/cne.23643

Burke, P., Kanbar, R., Hodges, W., Viar, K., Coates, M., Stornetta, R., & Guyenet, P. (2014). State-dependent regulation of breathing by the retrotrapezoid nucleus. FASEB JOURNAL, 28(1).

Guyenet, P. G. (2014). Regulation of Breathing and Autonomic Outflows by Chemoreceptors. COMPREHENSIVE PHYSIOLOGY, 4(4), 1511-1562. doi:10.1002/cphy.c140004

Abbott, S. B. G., Holloway, B. B., Viar, K. E., & Guyenet, P. G. (2014). Vesicular glutamate transporter 2 is required for the respiratory and parasympathetic activation produced by optogenetic stimulation of catecholaminergic neurons in the rostral ventrolateral medulla of mice in vivo. EUROPEAN JOURNAL OF NEUROSCIENCE, 39(1), 98-106. doi:10.1111/ejn.12421

Burke, P. G. R., Abbott, S. B. G., Coates, M. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2014). Optogenetic Stimulation of Adrenergic C1 Neurons Causes Sleep State-Dependent Cardiorespiratory Stimulation and Arousal with Sighs in Rats. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190(11), 1301-1310. doi:10.1164/rccm.201407-1262OC

2013

Stornetta, R. L., Macon, C. J., Nguyen, T. M., Coates, M. B., & Guyenet, P. G. (2013). Cholinergic neurons in the mouse rostral ventrolateral medulla target sensory afferent areas. BRAIN STRUCTURE & FUNCTION, 218(2), 455-475. doi:10.1007/s00429-012-0408-3

Guyenet, P. G., Abbott, S. B. G., & Stornetta, R. L. (2013). The respiratory chemoreception conundrum: Light at the end of the tunnel?. BRAIN RESEARCH, 1511, 126-137. doi:10.1016/j.brainres.2012.10.028

Depuy, S. D., Stornetta, R. L., Bochorishvili, G., Deisseroth, K., Witten, I., Coates, M., & Guyenet, P. G. (2013). Glutamatergic Neurotransmission between the C1 Neurons and the Parasympathetic Preganglionic Neurons of the Dorsal Motor Nucleus of the Vagus. JOURNAL OF NEUROSCIENCE, 33(4), 1486-1497. doi:10.1523/JNEUROSCI.4269-12.2013

Abbott, S. B. G., Depuy, S. D., Thanh, N., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2013). Selective Optogenetic Activation of Rostral Ventrolateral Medullary Catecholaminergic Neurons Produces Cardiorespiratory Stimulation in Conscious Mice. JOURNAL OF NEUROSCIENCE, 33(7), 3164-3177. doi:10.1523/JNEUROSCI.1046-12.2013

Abbott, S. B. G., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2013). Optogenetic Stimulation of C1 and Retrotrapezoid Nucleus Neurons Causes Sleep State-Dependent Cardiorespiratory Stimulation and Arousal in Rats. HYPERTENSION, 61(4), 835-+. doi:10.1161/HYPERTENSIONAHA.111.00860

Guyenet, P. G., & Abbott, S. B. G. (2013). Chemoreception and asphyxia-induced arousal. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 188(3), 333-343. doi:10.1016/j.resp.2013.04.011

Guyenet, P. G., Stornetta, R. L., Bochorishvili, G., DePuy, S. D., Burke, P. G. R., & Abbott, S. B. G. (2013). C1 neurons: the body's EMTs. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 305(3), R187-R204. doi:10.1152/ajpregu.00054.2013

Holloway, B. B., Stornetta, R. L., Bochorishvili, G., Erisir, A., Viar, K. E., & Guyenet, P. G. (2013). Monosynaptic Glutamatergic Activation of Locus Coeruleus and Other Lower Brainstem Noradrenergic Neurons by the C1 Cells in Mice. JOURNAL OF NEUROSCIENCE, 33(48), 18792-18805. doi:10.1523/JNEUROSCI.2916-13.2013

Wang, S., Shi, Y., Shu, S., Guyenet, P. G., & Bayliss, D. A. (2013). Phox2b-Expressing Retrotrapezoid Neurons Are Intrinsically Responsive to H+ and CO2. JOURNAL OF NEUROSCIENCE, 33(18), 7756-7761. doi:10.1523/JNEUROSCI.5550-12.2013

Wang, S., Benamer, N., Zanella, S., Kumar, N. N., Shi, Y., Bevengut, M., . . . Bayliss, D. A. (2013). TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons. JOURNAL OF NEUROSCIENCE, 33(41), 16033-16044. doi:10.1523/JNEUROSCI.2451-13.2013

2012

Bochorishvili, G., Stornetta, R. L., Coates, M. B., & Guyenet, P. G. (2012). Pre-Botzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons. JOURNAL OF COMPARATIVE NEUROLOGY, 520(5), 1047-1061. doi:10.1002/cne.22769

Abbott, S. B., Kanbar, R., Bochorishvili, G., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2012). C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats. JOURNAL OF PHYSIOLOGY-LONDON, 590(12), 2897-2915. doi:10.1113/jphysiol.2012.232157

Guyenet, P. G., Stornetta, R. L., Abbott, S. B. G., Depuy, S. D., & Kanbar, R. (2012). The Retrotrapezoid Nucleus and Breathing. ARTERIAL CHEMORECEPTION: FROM MOLECULES TO SYSTEMS, 758, 115-122. doi:10.1007/978-94-007-4584-1_16

Derecki, N. C., Cronk, J. C., Lu, Z., Xu, E., Abbott, S. B. G., Guyenet, P. G., & Kipnis, J. (2012). Wild-type microglia arrest pathology in a mouse model of Rett syndrome. NATURE, 484(7392), 105-+. doi:10.1038/nature10907

2011

Kanbar, R., Depuy, S. D., West, G. H., Stornetta, R. L., & Guyenet, P. G. (2011). Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents. JOURNAL OF PHYSIOLOGY-LONDON, 589(4), 903-917. doi:10.1113/jphysiol.2010.198374

DePuy, S. D., Kanbar, R., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2011). Control of Breathing by Raphe Obscurus Serotonergic Neurons in Mice. JOURNAL OF NEUROSCIENCE, 31(6), 1981-1990. doi:10.1523/JNEUROSCI.4639-10.2011

Abbott, S. B. G., Stornetta, R. L., Coates, M. B., & Guyenet, P. G. (2011). Phox2b-Expressing Neurons of the Parafacial Region Regulate Breathing Rate, Inspiration, and Expiration in Conscious Rats. JOURNAL OF NEUROSCIENCE, 31(45), 16410-16422. doi:10.1523/JNEUROSCI.3280-11.2011

Guyenet, P. G. (2011). Loss of brainstem serotonergic neurons impairs autoresuscitation in neonate rats: is this relevant to the sudden infant death syndrome?. JOURNAL OF PHYSIOLOGY-LONDON, 589(22), 5343-5344. doi:10.1113/jphysiol.2011.221143

Lazarenko, R. M., Stornetta, R. L., Bayliss, D. A., & Guyenet, P. G. (2011). Orexin A activates retrotrapezoid neurons in mice. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 175(2), 283-287. doi:10.1016/j.resp.2010.12.003

2010

Abbott, S. B. G., Stornetta, R. L., West, G. H., & Guyenet, P. G. (2010). PHOTOSTIMULATION OF CHANNELRHODOPSIN2-TRANSFECTED C1 NEURONS ACTIVATES PERIPHERAL SYMPATHETIC VASOMOTOR AFFERENTS AND NEURONS IN THE LOCUS COERULEUS AND A5 REGION IN SPRAGUE DAWLEY RATS. HYPERTENSION, 55(6), 1493.

Guyenet, P. G., Stornetta, R. L., Abbott, S. B. G., Depuy, S. D., Fortuna, M. G., & Kanbar, R. (2010). Central CO2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control. JOURNAL OF APPLIED PHYSIOLOGY, 108(4), 995-1002. doi:10.1152/japplphysiol.00712.2009

Guyenet, P. G., & Mulkey, D. K. (2010). Retrotrapezoid nucleus and parafacial respiratory group. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 173(3), 244-255. doi:10.1016/j.resp.2010.02.005

Kanbar, R., Stornetta, R. L., Cash, D. R., Lewis, S. J., & Guyenet, P. G. (2010). Photostimulation of Phox2b Medullary Neurons Activates Cardiorespiratory Function in Conscious Rats. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 182(9), 1184-1194. doi:10.1164/rccm.201001-0047OC

Lazarenko, R. M., Fortuna, M. G., Shi, Y., Mulkey, D. K., Takakura, A. C., Moreira, T. S., . . . Bayliss, D. A. (2010). Anesthetic Activation of Central Respiratory Chemoreceptor Neurons Involves Inhibition of a THIK-1-Like Background K+ Current. JOURNAL OF NEUROSCIENCE, 30(27), 9324-9334. doi:10.1523/JNEUROSCI.1956-10.2010

Guyenet, P. G., Stornetta, R. L., & Bayliss, D. A. (2010). Central Respiratory Chemoreception. JOURNAL OF COMPARATIVE NEUROLOGY, 518(19), 3883-3906. doi:10.1002/cne.22435