James R. Brookeman

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Primary Appointment

Professor of Research, Radiology and Medical Imaging

Research Interests

Magnetic Resonance Investigations mainly Hyperpolarized Gas and 3D Brain Imaging

Research Description

Our research seeks to improve methods of both two-dimensional and three-dimensional magnetic resonance image acquisition for diagnosis and for the planning and development of specialized radiofrequency coils for improved imaging used in surgery. The Department of Radiologyâs research laboratory is equipped with a 1.5 Tesla whole-body MR scanner. Plans are well advanced to install a new enhanced-gradient 1.5 Tesla MRI for improved cardiac and neurological studies and a 3 Tesla dedicated-head MR scanner for functional brain imaging.
Since 1996 we have pursued research in Hyperpolarized Noble Gas MR as well, employing laser-polarized Helium-3 and Xenon-129 to study lung ventilation, virtual colonoscopy, and tissue perfusion. At this time we are investigating a series of asthma and COPD subjects to evaluate the clinical potential of this new lung imaging technique.

Personal Statement

Our research seeks to improve methods of both two-dimensional and three-dimensional magnetic resonance image acquisition for diagnosis and for the planning and development of specialized radiofrequency coils for improved imaging used in surgery. The Department of Radiologyâs research laboratory is equipped with a 1.5 Tesla whole-body MR scanner. Plans are well advanced to install a new enhanced-gradient 1.5 Tesla MRI for improved cardiac and neurological studies brain imaging.
Since 1996 we have pursued research in Hyperpolarized Noble Gas MR as well, employing laser-polarized Helium-3 and Xenon-129 to study lung ventilation, virtual colonoscopy, and tissue perfusion. At this time we are investigating a series of asthma and COPD subjects to evaluate the clinical potential of this new lung imaging technique.

Selected Publications

Komlosi P, Altes TA, Qing K, Mooney KE, Miller GW, Mata JF, de Lange EE, Tobias WA, Cates GD, Brookeman JR, Mugler JP, Regional anisotropy of airspace orientation in the lung as assessed with hyperpolarized helium-3 diffusion MRI., 2015; Journal of magnetic resonance imaging : JMRI. () . PMID: 26012720

Qing K, Altes TA, Tustison NJ, Feng X, Chen X, Mata JF, Miller GW, de Lange EE, Tobias WA, Cates GD, Brookeman JR, Mugler JP, Rapid acquisition of helium-3 and proton three-dimensional image sets of the human lung in a single breath-hold using compressed sensing., 2014; Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. () . PMID: 25335080 | PMCID: PMC4475670

Miller GW, Mugler JP, Altes TA, Cai J, Mata JF, de Lange EE, Tobias WA, Cates GD, Brookeman JR, A short-breath-hold technique for lung pO2 mapping with 3He MRI., 2009; Magnetic resonance in medicine. 63(1) 127-36. PMID: 19918891 | PMCID: PMC3320736

Mata JF, Altes TA, Ruppert K, Hagspiel KD, Miller GW, Brookeman JR, Mugler JP, Assessment of in vitro vs. in vivo lung structure using hyperpolarized helium-3 diffusion magnetic resonance imaging., 2009; Magnetic resonance imaging. 27(6) 845-51. PMID: 19269767

Mugler JP, Wang C, Miller GW, Cates GD, Mata JF, Brookeman JR, de Lange EE, Altes TA, Helium-3 diffusion MR imaging of the human lung over multiple time scales., 2008; Academic radiology. 15(6) 693-701. PMID: 18486006 | PMCID: PMC2494939

Wang C, Miller GW, Altes TA, de Lange EE, Cates GD, Mata JF, Brookeman JR, Mugler JP, Extending the range of diffusion times for regional measurement of the 3He ADC in human lungs., 2008; Magnetic resonance in medicine. 59(3) 673-8. PMID: 18306375

Cai J, Altes TA, Miller GW, Sheng K, Read PW, Mata JF, Zhong X, Cates GD, de Lange EE, Mugler JP, Brookeman JR, MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation., 2007; Magnetic resonance in medicine. 58(2) 373-80. PMID: 17654579

Cai J, Miller GW, Altes TA, Read PW, Benedict SH, de Lange EE, Cates GD, Brookeman JR, Mugler JP, Sheng K, Direct measurement of lung motion using hyperpolarized helium-3 MR tagging., 2007; International journal of radiation oncology, biology, physics. 68(3) 650-3. PMID: 17445997 | PMCID: PMC3658834

de Lange EE, Altes TA, Patrie JT, Parmar J, Brookeman JR, Mugler JP, Platts-Mills TA, The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging., 2007; The Journal of allergy and clinical immunology. 119(5) 1072-8. PMID: 17353032

Cai J, Read PW, Altes TA, Molloy JA, Brookeman JR, Sheng K, Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRI., 2007; Physics in medicine and biology. 52(2) 365-73. PMID: 17202620