Mark Kester
- Phone: 434-243-2645
- Fax: 434-243-8058
Primary Appointment
Professor, Unaffiliated
Education
- PhD, State University of New York at Buffalo
- Postdoc, University of Illinois, Chicago
Research Disciplines
Biochemistry, Biotechnology, Cancer Biology, Cardiovascular Biology, Epigenetics, Experimental Pathology, Immunology, Infectious Diseases/Biodefense, Metabolism, Molecular Biology, Molecular Pharmacology, Structural Biology, Translational Science
Research Description
Personal Statement
Training
- Biotechnology Training Grant
- Cancer Research Training in Molecular Biology
- Training in Cell and Molecular Biology
- Training in the Pharmacological Sciences
Selected Publications
Barth BM, Shanmugavelandy SS, Kaiser JM, McGovern C, AltınoÄlu EÄ°, Haakenson JK, Hengst JA, Gilius EL, Knupp SA, Fox TE, Smith JP, Ritty TM, Adair JH, Kester M, PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate., 2013; ACS nano. 7(3) 2132-44. PMID: 23373542 | PMCID: PMC3757127
Ryland LK, Doshi UA, Shanmugavelandy SS, Fox TE, Aliaga C, Broeg K, Baab KT, Young M, Khan O, Haakenson JK, Jarbadan NR, Liao J, Wang HG, Feith DJ, Loughran TP, Liu X, Kester M, C6-ceramide nanoliposomes target the warburg effect in chronic lymphocytic leukemia., 2013; PloS one. 8(12) e84648. PMID: 24367685 | PMCID: PMC3868606
Hankins JL, Ward KE, Linton SS, Barth BM, Stahelin RV, Fox TE, Kester M, Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex., 2013; The Journal of biological chemistry. 288(27) 19726-38. PMID: 23696646 | PMCID: PMC3707677
Adiseshaiah PP, Clogston JD, McLeland CB, Rodriguez J, Potter TM, Neun BW, Skoczen SL, Shanmugavelandy SS, Kester M, Stern ST, McNeil SE, Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models., 2013; Cancer letters. 337(2) 254-65. PMID: 23664889 | PMCID: PMC3722309
Barth BM, Shanmugavelandy SS, Tacelosky DM, Kester M, Morad SA, Cabot MC, Gaucher's disease and cancer: a sphingolipid perspective., 2013; Critical reviews in oncogenesis. 18(3) 221-34. PMID: 23510065 | PMCID: PMC3604879
Morad SA, Madigan JP, Levin JC, Abdelmageed N, Karimi R, Rosenberg DW, Kester M, Shanmugavelandy SS, Cabot MC, Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53., 2013; Biochemical pharmacology. 85(8) 1057-65. PMID: 23353700 | PMCID: PMC3604153
Young MM, Kester M, Wang HG, Sphingolipids: regulators of crosstalk between apoptosis and autophagy., 2012; Journal of lipid research. 54(1) 5-19. PMID: 23152582 | PMCID: PMC3520539
Morad SA, Levin JC, Shanmugavelandy SS, Kester M, Fabrias G, Bedia C, Cabot MC, Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer., 2012; Molecular cancer therapeutics. 11(11) 2352-61. PMID: 22962326 | PMCID: PMC3495995
Fox TE, Young MM, Pedersen MM, Han X, Gardner TW, Kester M, Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death., 2012; Investigative ophthalmology & visual science. 53(11) 7257-67. PMID: 22952117 | PMCID: PMC3478036
Tacelosky DM, Creecy AE, Shanmugavelandy SS, Smith JP, Claxton DF, Adair JH, Kester M, Barth BM, Calcium phosphosilicate nanoparticles for imaging and photodynamic therapy of cancer., 2012; Discovery medicine. 13(71) 275-85. PMID: 22541615
Kaiser JM, Imai H, Haakenson JK, Brucklacher RM, Fox TE, Shanmugavelandy SS, Unrath KA, Pedersen MM, Dai P, Freeman WM, Bronson SK, Gardner TW, Kester M, Nanoliposomal minocycline for ocular drug delivery., 2012; Nanomedicine : nanotechnology, biology, and medicine. 9(1) 130-40. PMID: 22465498 | PMCID: PMC3762261
Young MM, Takahashi Y, Khan O, Park S, Hori T, Yun J, Sharma AK, Amin S, Hu CD, Zhang J, Kester M, Wang HG, Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis., 2012; The Journal of biological chemistry. 287(15) 12455-68. PMID: 22362782 | PMCID: PMC3320995