Avril V. Somlyo
- Email: avs5u@virginia.edu
- Phone: 434-982-0825
Primary Appointment
Wage Faculty, Molecular Physiology and Biological Physics
Education
- MSc, Pathology, University of Saskatchewan, Canada
- PhD, Physiology, University of Pennsylvania, PA
Research Disciplines
Biophysics, Cardiovascular Biology, Physiology
Personal Statement
Training
- Basic Cardiovascular Research Training Grant
Selected Publications
2018
Artamonov, M. V., Sonkusare, S. K., Good, M. E., Momotani, K., Eto, M., Isakson, B. E., . . . Somlyo, A. V. (2018). RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger. SCIENCE SIGNALING, 11(554). doi:10.1126/scisignal.aar3924
DeLalio, L. J., Keller, A. S., Chen, J., Boyce, A. K. J., Artamonov, M. V., Askew-Page, H. R., . . . Isakson, B. E. (2018). Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(9), 2065-2078. doi:10.1161/ATVBAHA.118.311290
2016
Utepbergenov, D., Hennig, P. M., Derewenda, U., Artamonov, M. V., Somlyo, A. V., & Derewenda, Z. S. (2016). Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2). PLOS ONE, 11(10). doi:10.1371/journal.pone.0164343
Amin, E., Jaiswal, M., Derewenda, U., Reis, K., Nouri, K., Koessmeier, K. T., . . . Ahmadian, M. R. (2016). Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(39), 20353-20371. doi:10.1074/jbc.M116.736967
2015
An, C., Bhetwal, B. P., Sanders, K. M., Somlyo, A. V., & Perrino, B. A. (2015). Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension. PLOS ONE, 10(8). doi:10.1371/journal.pone.0134876
Artamonov, M. V., Jin, L., Franke, A. S., Momotani, K., Ho, R., Dong, X. R., . . . Somlyo, A. V. (2015). Signaling Pathways That Control Rho Kinase Activity Maintain the Embryonic Epicardial Progenitor State. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(16), 10353-10367. doi:10.1074/jbc.M114.613190
Billaud, M., Chiu, Y. -H., Lohman, A. W., Parpaite, T., Butcher, J. T., Mutchler, S. M., . . . Isakson, B. E. (2015). A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. SCIENCE SIGNALING, 8(364). doi:10.1126/scisignal.2005824
Somlyo, A. V. (2015). Smooth muscle mysosin filament controversy, once again?. JOURNAL OF PHYSIOLOGY-LONDON, 593(2), 473-475. doi:10.1113/jphysiol.2014.285866
2014
Straub, A. C., Butcher, J. T., Billaud, M., Mutchler, S. M., Artamonov, M. V., Nguyen, A. T., . . . Isakson, B. E. (2014). Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(12), 2594-2600. doi:10.1161/ATVBAHA.114.303974
Somlyo, A. (2014). Regulatory circuits in cell motility. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 35(3-4), 235. doi:10.1007/s10974-013-9372-7
Lakshmikanthan, S., Zieba, B. J., Ge, Z. -D., Momotani, K., Zheng, X., Lund, H., . . . Chrzanowska-Wodnicka, M. (2014). Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(7), 1486-+. doi:10.1161/ATVBAHA.114.303678
2013
Carlson, D. A., Franke, A. S., Weitzel, D. H., Speer, B. L., Hughes, P. F., Hagerty, L., . . . Haystead, T. A. J. (2013). Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor. ACS CHEMICAL BIOLOGY, 8(12), 2715-2723. doi:10.1021/cb400407c
Artamonov, M. V., Momotani, K., Stevenson, A., Trentham, D. R., Derewenda, U., Derewenda, Z. S., . . . Somlyo, A. V. (2013). Agonist-induced Ca2+ Sensitization in Smooth Muscle REDUNDANCY OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS (RhoGEFs) AND RESPONSE KINETICS, A CAGED COMPOUND STUDY. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(47), 34030-34040. doi:10.1074/jbc.M113.514596
Derewenda, U., Artamonov, M., Szukalska, G., Utepbergenov, D., Olekhnovich, N., Parikh, H. I., . . . Derewenda, Z. S. (2013). Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Ã resolution. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 69, 266-275. doi:10.1107/S0907444912045520
Somlyo, A. (2013). Obituary of Richard A. Murphy. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 34(5-6), 437-439. doi:10.1007/s10974-013-9369-2
Amin, E., Dubey, B. N., Zhang, S. -C., Gremer, L., Dvorsky, R., Moll, J. M., . . . Ahmadian, M. R. (2013). Rho-kinase: regulation, (dys) function, and inhibition. BIOLOGICAL CHEMISTRY, 394(11), 1399-1410. doi:10.1515/hsz-2013-0181
Artamonov, M., Momotani, K., Utepbergenov, D., Franke, A., Khromov, A., Derewenda, Z. S., & Somlyo, A. V. (2013). The p90 Ribosomal S6 Kinase (RSK) Is a Mediator of Smooth Muscle Contractility. PLOS ONE, 8(3). doi:10.1371/journal.pone.0058703
2012
Momotani, K., & Somlyo, A. V. (2012). p63RhoGEF: A New Switch for Gq-Mediated Activation of Smooth Muscle. TRENDS IN CARDIOVASCULAR MEDICINE, 22(5), 122-127. doi:10.1016/j.tcm.2012.07.007
Khromov, A. S., Momotani, K., Jin, L., Artamonov, M. V., Shannon, J., Eto, M., & Somlyo, A. V. (2012). Molecular Mechanism of Telokin-mediated Disinhibition of Myosin Light Chain Phosphatase and cAMP/cGMP-induced Relaxation of Gastrointestinal Smooth Muscle. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(25), 20975-20985. doi:10.1074/jbc.M112.341479
2011
Momotani, K., Artamonov, M. V., Utepbergenov, D., Derewenda, U., Derewenda, Z. S., & Somlyo, A. V. (2011). p63RhoGEF Couples Gαq/11-Mediated Signaling to Ca2+ Sensitization of Vascular Smooth Muscle Contractility. CIRCULATION RESEARCH, 109(9), 993-U42. doi:10.1161/CIRCRESAHA.111.248898
Hoofnagle, M. H., Neppl, R. L., Berzin, E. L., Pipes, G. C. T., Olson, E. N., Wamhoff, B. W., . . . Owens, G. K. (2011). Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 300(5), H1707-H1721. doi:10.1152/ajpheart.01192.2010
Zieba, B. J., Artamonov, M. V., Jin, L., Momotani, K., Ho, R., Franke, A. S., . . . Somlyo, A. V. (2011). The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(19), 16681-16692. doi:10.1074/jbc.M110.205062
Bielnicki, J. A., Shkumatov, A. V., Derewenda, U., Somlyo, A. V., Svergun, D. I., & Derewenda, Z. S. (2011). Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(40), 35163-35175. doi:10.1074/jbc.M111.270918
2010
Jin, L., Gan, Q., Zieba, B. J., Goicoechea, S. M., Owens, G. K., Otey, C. A., & Somlyo, A. V. (2010). The Actin Associated Protein Palladin Is Important for the Early Smooth Muscle Cell Differentiation. PLOS ONE, 5(9). doi:10.1371/journal.pone.0012823
Yoshida, T., Gan, Q., Franke, A. S., Ho, R., Zhang, J., Chen, Y. E., . . . Owens, G. K. (2010). Smooth and Cardiac Muscle-selective Knock-out of Kruppel-like Factor 4 Causes Postnatal Death and Growth Retardation. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(27), 21175-21184. doi:10.1074/jbc.M110.112482