Dr. Glover has been active in pre-clinical research in the field of Nuclear Cardiology for over 25 years. His main research interest has been the study of the myocardial extraction and clearance kinetic properties of new radiopharmaceuticals for non-invasive imaging of myocardial perfusion and viability. The Glover lab pioneered the use of A2A adenosine receptor agonists as vasodilators for pharmacologic stress imaging. Recent work in his laboratory has been focused on the development of targeted radiolabeled probes for molecular imaging of the cardiovascular system.
For the most current list of Glover Lab publications, please click here.
Children's Hospital of Boston
Dr. David Glover continues his long lasting relationship with the Children’s Hospital of Boston who have funded his research on experimental studies in the Experimental Nuclear Cardiology Laboratory, which is part of the Robert M. Berne Cardiovascular Research Center at the University of Virginia. The project is to evaluate the myocardial first pass extraction fraction and the flow-extraction properties of the F19-labeled myocardial perfusion imaging (18F-MPI) agents over a wide range of blood flow.
Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA. B-cell aortic homing and atheroprotection depend on Id3. Circ Res. 2012 Jan 6;110(1):e1-12. doi: 10.1161/CIRCRESAHA.111.256438. Epub 2011 Oct 27.
Broisat A, Ruiz M, Goodman NC, Hanrahan SM, Reutter BW, Brennan KM, Janabi M, Schaefer S, Watson DD, Beller GA, VanBrocklin HF, Glover DK. Myocardial uptake of 7'-(Z)-[(123)I]iodorotenone during vasodilator stress in dogs with critical coronary stenoses. Circ Cardiovasc Imaging. 2011 Nov;4(6):685-92. doi: 10.1161/CIRCIMAGING.110.961763. Epub 2011 Sep 14.
Li D, Patel AR, Klibanov AL, Kramer CM, Ruiz M, Kang BY, Mehta JL, Beller GA, Glover DK, Meyer CH. Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT/CT and magnetic resonance. Circ Cardiovasc Imaging. 2010 Jul;3(4):464-72. doi: 10.1161/CIRCIMAGING.109.896654. Epub 2010 May 4.