Nic Greene

Research Interests

I received my Ph.D. from Texas A&M University in 2010 and previously received bachelor’s and master’s degrees from the University of South Carolina.  My doctoral studies focused on the impacts of exercise training in the treatment of dyslipidemia and how skeletal muscle regulates these effects.  Particularly, I investigated the role of peroxisome proliferator-activated receptor δ (PPARδ) in mediating oxidative and lipoprotein adaptations following exercise training and the subsequent consequence on blood lipids and lipoproteins.  In these studies, I utilized both human and rat models of obesity to better understand the metabolic impairments and how exercise training may correct such impairments.

My primary research interests are in the conditions that lead to metabolic impairments (especially obesity and insulin resistance) and in the corrective effects of exercise training.  In pursuing these interests, I realized the importance of understanding the molecular mechanisms of the etiology (i.e., insulin resistance) so we can target the problems with corrective measures, such as exercise training and pharmaceutical interventions. In the Yan lab, I will be working on the role of lipid overload in the induction of mitochondrial dysfunction and insulin resistance.

Selected Publications

Mats I. Nilsson, Nicholas P. Greene, Justin P. Dobson, Michael P. Wiggs, Heath G. Gasier, Brandon R. Macias, Kevin L. Shimkus, James D. Fluckey.
Insulin resistance syndrome blunts the mitochondrial anabolic response following resistance exercise.
American Journal of Physiology, Endocrinology and Metabolism 299(3): E466-74, 2010.

Nicholas P. Greene, Bradley S. Lambert, Elizabeth S. Greene, Aaron F. Carbuhn , John S. Green, Stephen F. Crouse.
Comparative Efficacy of Water and Land Treadmill Training for Overweight or Obese Adults.
Medicine & Science in Sports & Exercise 41: 1808-1815, 2009.

Nicholas P. Greene, Elizabeth S. Greene, Aaron F. Carbuhn, John S. Green, Stephen F. Crouse.
VO2 Prediction and Cardiorespiratory Responses During Underwater Treadmill Exercise.
Accepted for publication in Research Quarterly for Sport and Exercise, accepted for publication March 14, 2010.

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