Position: Assistant Professor
Office Phone: 434-982-4403
Office Address: MR4 6031A
About Dr. Connelly
My long-term goal is to create a research program centered around dissecting complex human genetic disease on the level of basic transcriptional control and the epigenetic modulation of transcriptional regulation.
Jessica completed a Bachelor of Science in Chemistry with an emphasis in Biochemistry at Richard Stockton College in 1997.
As a graduate student, she had the unique experience of training with two professors, both well–established in the field of epigenetics. In 1997, she began her training in Dr. John Lucchesi’s lab, where she studied the epigenetic aspects of dosage compensation in Drosophila melanogaster. She moved to Stony Brook University in the summer of 1999 and completed her PhD in 2004 under the mentorship of a yeast epigeneticist, Dr. Rolf Sternglanz. Jessica’s PhD thesis pursued her interest in the histone code by characterizing a domain (the BAH domain) that resides within proteins involved in regulating transcription through chromatin compaction. (For more information see research statement)
Jessica was a postdoc at the Duke Center for Human Genetics from 2004-2008. Her postdoctoral work allowed her to explore the fields of human genetics, genomics, and cardiovascular disease. She trained under Dr. Elizabeth Hauser, a human statistical geneticist, and Dr. Simon G. Gregory, a human genomicist.
I moved to Charlottesville in December of 2008 and started my faculty position in February 2009. We’ve settled in and love living here. I’m married to Dr. Jamie Morris, who is an assistant professor in Psychology at UVA. I have a fantastic son name Kegan who was born in 2009. I spend most of my time when I’m not in the lab with my boys and my awesome dogs, Sarah and Jack.
Current Research Support
R01ES017638 (Connelly, JJ) 09/01/09 – 08/30/13 PI
R21HD066487 (Connelly, JJ) PI
R01OD007887 (Connelly, JJ and Morris, JP) PI
R01 (Connelly, JJ and Taylor, AG) PI
Connelly JJ, Yuan P, Hsu HC, Li Z, Xu RM, and Sternglanz R. Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain. Mol Cell Biol.. 2006 Apr; 26(8): 3256-65.
Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC, Granger CB, Haines JL, Jones CJH, Vance JM, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER, Gregory SG. GATA2 is associated with familial early onset coronary artery disease. PLoS Genetics 2006 Aug; 2(8): e139.
Connelly JJ, Shah SH, Doss JF, Gadson S, Crosslin DR, Wang T, Hale AB, Lou X, Nelson S, Haynes C, Crossman DC, Mooser V, Granger CB, Jones CJH, Kraus WE, Hauser ER, Gregory SG. Genetic and functional association of FAM5C with myocardial infarction. BMC Med Genet. 2008 Apr 22;9:33.