Brant Isakson

Lab: Isakson

Position: Assistant Professor

Degrees: PhD

Email: brant@virginia.edu

Office Phone: 434-924-8691, Fax: 434-924-2828

Office Address: MR4 6071

Messenger Mail: PO Box 801394

Website: http://www.cvrc.virginia.edu/Isakson/

PubMed listings for Brant Isakson

Research Interests

My lab focuses on intercellular communication in the microvasculature and how this regulates the critical proces of vessel dilation and constriction--elucidating this fundamental proces is key to understanding such diseases as hypertention and the associated vascular dysfunction seen with obesity.


Selected Publications



Billaud M, Lohman AW, Straub AC, Looft-Wilson R, Johnstone SR, Araj CA, Best AK, Chekeni FB, Ravichandran KS, Penuela S, Laird DW, Isakson BE.  Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction.  Circ Res 109, 80-5, 2011.


Heberlein KR, Straub AC, Best AK, Greyson MA, Looft-Wilson RC, Sharma PR, Meher A, Leitinger N, Isakson BE.  Plasminogen activator inhibitor-1 regulates myoendothelial junction formation.  Circ Res 106:  1092-102, 2010.

 

 


Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS.  Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.  Nature 467:  863-7, 2010.



Straub AC, Lohman AW, Billaud M, Johnstone SR, Swyer ST, Lee MY, Bortz PS, Best AK, Columus L, Gaston B, and Isakson BE.  Endothelial cell expression of haemoglobin alpha regulates nitric oxide signalling.  Nature, [Oct 2012--Epub Ahead of Print]


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